OR52D1

OR52D1
Identifiers
Aliases	OR52D1 , OR11-43, olfactory receptor family 52 subfamily D member 1, olfactory receptor family 52 subfamily D member 1 (gene/pseudogene)
External IDs	MGI: 3030480 HomoloGene: 17481 GeneCards: OR52D1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 5,488,685 bp [1] End 5,489,749 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 103,754,080 bp [2] End 103,758,973 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve Achilles tendon n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 390066 259058 Ensembl ENSG00000181609 ENSMUSG00000073931 UniProt Q9H346 Q8VGW2 RefSeq (mRNA) NM_001005163 NM_147056 RefSeq (protein) NP_001005163 NP_667267 Location (UCSC) Chr 11: 5.49 – 5.49 Mb Chr 7: 103.75 – 103.76 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 52D1 is a protein that in humans is encoded by the OR52D1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

Compared to other olfactory receptors such as OR1G1, OR52D1 has a more narrow/specific range of ligands. ^[6]

Agonists:

• Methyl octanoate ^[6]
• "Better activated by acids, aldehydes, ketones and esters than alcohols or pyrazines" ^[6]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000181609 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000073931 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR52D1 olfactory receptor, family 52, subfamily D, member 1".
6. Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi: 10.1093/chemse/bji002 . PMID   15647465.

Further reading

• Bulger M, van Doorninck JH, Saitoh N, Telling A, Farrell C, Bender MA, et al. (April 1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi: 10.1073/pnas.96.9.5129 . PMC   21828 . PMID   10220430.
• Bulger M, Bender MA, van Doorninck JH, Wertman B, Farrell CM, Felsenfeld G, et al. (December 2000). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proceedings of the National Academy of Sciences of the United States of America. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi: 10.1073/pnas.97.26.14560 . PMC   18958 . PMID   11121057.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR52D1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.