OR51E2

OR51E2
Identifiers
Aliases	OR51E2 , OR51E3P, OR52A2, PSGR, olfactory receptor family 51 subfamily E member 2, HPRAJ
External IDs	OMIM: 611268 MGI: 2157548 HomoloGene: 23713 GeneCards: OR51E2
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 4,680,171 bp [1] End 4,697,854 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 102,387,718 bp [2] End 102,408,678 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium popliteal artery prostate right coronary artery smooth muscle tissue transverse colon rectum left coronary artery placenta myometrium Top expressed in belly cord carotid body trigeminal ganglion digastric muscle extraocular muscle temporal muscle triceps brachii muscle respiratory epithelium olfactory epithelium superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity steroid hormone receptor activity signaling receptor activity Cellular component membrane integral component of membrane plasma membrane early endosome membrane intracellular organelle endosome Biological process sensory perception of smell steroid hormone mediated signaling pathway signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell positive regulation of blood pressure cellular response to fatty acid positive regulation of renin secretion into blood stream G protein-coupled receptor signaling pathway cell migration melanocyte differentiation positive regulation of cAMP-mediated signaling melanocyte proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81285 170639 Ensembl ENSG00000167332 ENSMUSG00000043366 UniProt Q9H255 Q8VBV9 RefSeq (mRNA) NM_030774 NM_001168503 NM_130866 RefSeq (protein) NP_110401 NP_001161975 NP_570936 Location (UCSC) Chr 11: 4.68 – 4.7 Mb Chr 7: 102.39 – 102.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

Structure

Structure of the olfactory receptor OR51E2 (green) complexed with miniGs399 and a propionic acid ligand (orange).

Its structure was determined in 2023, the first elucidation of the structure of a human olfactory receptor. ^{[7] [8] [9]}

Ligands

OR51E2 is a relatively narrowly tuned olfactory receptor, meaning it responds only to a relatively small set of related odorants. ^[10]

OR51E2 responds to short-chain fatty acids, ^[11] including in particular propionic acid. ^[10]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000167332 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000043366 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Xu LL, Stackhouse BG, Florence K, Zhang W, Shanmugam N, Sesterhenn IA, et al. (December 2000). "PSGR, a novel prostate-specific gene with homology to a G protein-coupled receptor, is overexpressed in prostate cancer". Cancer Research. 60 (23): 6568–6572. PMID   11118034.
6. "Entrez Gene: OR51E2 olfactory receptor, family 51, subfamily E, member 2".
7. PDB: 8F76 ​; Billesbølle CB, de March CA, van der Velden WJ, Ma N, Tewari J, Del Torrent CL, et al. (March 2023). "Structural basis of odorant recognition by a human odorant receptor". Nature. 615 (7953): 742–749. Bibcode:2023Natur.615..742B. doi:10.1038/s41586-023-05798-y. PMC   10580732 . PMID   36922591. S2CID   254975795.
8. Kim SE (2023). "Scientists sniff out the structure of a human olfactory receptor". Chemical & Engineering News . 101 (10): 6. doi:10.1021/cen-10110-scicon3.
9. Parry W (1 May 2023). "How a Human Smell Receptor Works Is Finally Revealed". Quanta Magazine .
10. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.
11. Pluznick JL, Protzko RJ, Gevorgyan H, Peterlin Z, Sipos A, Han J, et al. (March 2013). "Olfactory receptor responding to gut microbiota-derived signals plays a role in renin secretion and blood pressure regulation". Proceedings of the National Academy of Sciences of the United States of America. 110 (11): 4410–4415. Bibcode:2013PNAS..110.4410P. doi: 10.1073/pnas.1215927110 . PMC   3600440 . PMID   23401498.

Further reading

• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, et al. (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.
• Xia C, Ma W, Wang F, Liu M (September 2001). "Identification of a prostate-specific G-protein coupled receptor in prostate cancer". Oncogene. 20 (41): 5903–5907. doi: 10.1038/sj.onc.1204803 . PMID   11593396.
• Yuan TT, Toy P, McClary JA, Lin RJ, Miyamoto NG, Kretschmer PJ (October 2001). "Cloning and genetic characterization of an evolutionarily conserved human olfactory receptor that is differentially expressed across species". Gene. 278 (1–2): 41–51. doi:10.1016/S0378-1119(01)00709-0. PMID   11707321.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Weng J, Wang J, Cai Y, Stafford LJ, Mitchell D, Ittmann M, Liu M (February 2005). "Increased expression of prostate-specific G-protein-coupled receptor in human prostate intraepithelial neoplasia and prostate cancers". International Journal of Cancer. 113 (5): 811–818. doi: 10.1002/ijc.20635 . PMID   15499628. S2CID   27473061.
• Weng J, Ma W, Mitchell D, Zhang J, Liu M (December 2005). "Regulation of human prostate-specific G-protein coupled receptor, PSGR, by two distinct promoters and growth factors". Journal of Cellular Biochemistry. 96 (5): 1034–1048. doi:10.1002/jcb.20600. PMID   16149059. S2CID   20908653.
• Xu LL, Sun C, Petrovics G, Makarem M, Furusato B, Zhang W, et al. (2006). "Quantitative expression profile of PSGR in prostate cancer". Prostate Cancer and Prostatic Diseases. 9 (1): 56–61. doi: 10.1038/sj.pcan.4500836 . PMID   16231015.
• Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M (June 2006). "The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase". The Prostate. 66 (8): 847–857. doi:10.1002/pros.20389. PMID   16491480. S2CID   25548828.

External links

• OR51E2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.