OR51L1

OR51L1
Identifiers
Aliases	OR51L1 , OR11-31, olfactory receptor family 51 subfamily L member 1
External IDs	HomoloGene: 73944 GeneCards: OR51L1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 4,994,851 bp [1] End 5,005,536 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prostate n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 119682 n/a Ensembl ENSG00000176798 n/a UniProt Q8NGJ5 n/a RefSeq (mRNA) NM_001004755 n/a RefSeq (protein) NP_001004755 n/a Location (UCSC) Chr 11: 4.99 – 5.01 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 51L1 is a protein that in humans is encoded by the OR51L1 gene. ^[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[3]

Ligands

• Allyl phenylacetate ^{[4] [5]}
• Hexanoic acid ^[4]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000176798 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR51L1 olfactory receptor, family 51, subfamily L, member 1".
4. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.
5. Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi: 10.1371/journal.pgen.1002821 . PMC   3395614 . PMID   22807691.

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR51L1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.