OR1A1

Last updated
OR1A1
Identifiers
Aliases OR1A1 , OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
External IDs OMIM: 618046 MGI: 1333770 HomoloGene: 8219 GeneCards: OR1A1
Orthologs
SpeciesHumanMouse
Entrez

8383

258706

Ensembl

ENSG00000172146

ENSMUSG00000070377

UniProt

Q9P1Q5

n/a

RefSeq (mRNA)

NM_014565
NM_001386104

NM_146711

RefSeq (protein)

NP_055380

n/a

Location (UCSC) Chr 17: 3.21 – 3.22 Mb Chr 11: 74.1 – 74.1 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene. [5] [6]

Contents

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [6]

Ligands

OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules. [7] [8] Examples of known ligands, most of which have citrus or fruity smells: [9] [10]

See also

Related Research Articles

<span class="mw-page-title-main">Olfactory receptor</span> Chemoreceptors expressed in cell membranes of olfactory receptor neurons

Olfactory receptors (ORs), also known as odorant receptors, are chemoreceptors expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants which give rise to the sense of smell. Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. In vertebrates, these receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene family consisting of around 400 genes in humans and 1400 genes in mice. In insects, olfactory receptors are members of an unrelated group of ligand-gated ion channels.

<span class="mw-page-title-main">OR2C1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.

<span class="mw-page-title-main">OR1E1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.

<span class="mw-page-title-main">OR6A2</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene. It is Class II (tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.

<span class="mw-page-title-main">OR1A2</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 1A2 is a protein that in humans is encoded by the OR1A2 gene.

<span class="mw-page-title-main">OR1C1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 1C1 is a protein that in humans is encoded by the OR1C1 gene.

<span class="mw-page-title-main">OR10H2</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 10H2 is a protein that in humans is encoded by the OR10H2 gene.

<span class="mw-page-title-main">OR2W1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.

<span class="mw-page-title-main">OR7A5</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 7A5 is a protein that in humans is encoded by the OR7A5 gene.

<span class="mw-page-title-main">OR7C1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 7C1 is a protein that in humans is encoded by the OR7C1 gene.

<span class="mw-page-title-main">OR8B8</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 8B8 is a protein that in humans is encoded by the OR8B8 gene.

<span class="mw-page-title-main">OR2J2</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2J2 is a protein that in humans is encoded by the OR2J2 gene.

<span class="mw-page-title-main">OR51L1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 51L1 is a protein that in humans is encoded by the OR51L1 gene.

<span class="mw-page-title-main">OR10J5</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.

<span class="mw-page-title-main">OR7D4</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.

<span class="mw-page-title-main">OR2AG1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.

<span class="mw-page-title-main">OR51E1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.

<span class="mw-page-title-main">OR13H1</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 13H1 is a protein that in humans is encoded by the OR13H1 gene.

<span class="mw-page-title-main">OR2M7</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2M7 is a protein that in humans is encoded by the OR2M7 gene.

<span class="mw-page-title-main">OR2J3</span> Protein-coding gene in the species Homo sapiens

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172146 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000070377 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
  6. 1 2 "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".
  7. 1 2 Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.
  8. 1 2 Block E, Batista VS, Matsunami H, Zhuang H, Ahmed L (May 2017). "The role of metals in mammalian olfaction of low molecular weight organosulfur compounds". Natural Product Reports. 34 (5): 529–557. doi:10.1039/c7np00016b. PMC   5542778 . PMID   28471462.
  9. 1 2 3 Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID   17601748.
  10. ↑ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi: 10.1371/journal.pone.0093037 . PMC   3973694 . PMID   24695519.

Further reading

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