OR51E1

OR51E1
Identifiers
Aliases	OR51E1 , D-GPCR, DGPCR, GPR136, GPR164, OR51E1P, OR52A3P, POGR, PSGR2, olfactory receptor family 51 subfamily E member 1
External IDs	OMIM: 611267 MGI: 3030392 HomoloGene: 17503 GeneCards: OR51E1
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 4,643,420 bp [1] End 4,655,488 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 E3 Start 102,351,422 bp [2] End 102,361,271 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte tibialis anterior muscle pancreatic ductal cell popliteal artery left ventricle placenta prostate abdominal fat right coronary artery smooth muscle tissue Top expressed in esophagus spermatocyte spermatid artery muscle tissue skeletal muscle tissue carotid body major salivary gland duodenum submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity olfactory receptor activity G protein-coupled receptor activity Cellular component membrane integral component of membrane plasma membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 143503 259097 Ensembl ENSG00000180785 ENSMUSG00000070423 UniProt Q8TCB6 Q8VGZ7 RefSeq (mRNA) NM_152430 NM_147093 RefSeq (protein) NP_689643 NP_667304 Location (UCSC) Chr 11: 4.64 – 4.66 Mb Chr 7: 102.35 – 102.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

The receptor is associated with some compounds with a "cheese" or "sour" scent note. Examples of compounds that activate OR51E1 include:

• butyl butyryl lactate ^[6]
• isovaleric acid ^[7]
• nonanoic acid ^[6]
• 3-methylpentanoic acid ^[8]
• 4-methylpentanoic acid ^[8]

The following are in decreasing order of activity: ^[9]

• butyric acid
• methyl eugenol
• methyl salicylate
• (+)-menthol
• eugenyl acetate
• 2,4-dinitrotoluene
• pyrazine
• dimethyl disulfide
• methyl furfuryl disulfide
• pentanol
• propanal

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000180785 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000070423 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR51E1 olfactory receptor, family 51, subfamily E, member 1".
6. Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC   2774247 . PMID   19261596.
7. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC   3990440 . PMID   24316890.
8. Fujita Y, Takahashi T, Suzuki A, Kawashima K, Nara F, Koishi R (2007). "Deorphanization of Dresden G protein-coupled receptor for an odorant receptor". Journal of Receptor and Signal Transduction Research. 27 (4): 323–34. doi:10.1080/10799890701534180. PMID   17885925. S2CID   42999502.
9. Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi: 10.1371/journal.pgen.1002821 . PMC   3395614 . PMID   22807691.

Further reading

• Wang J, Weng J, Cai Y, Penland R, Liu M, Ittmann M (June 2006). "The prostate-specific G-protein coupled receptors PSGR and PSGR2 are prostate cancer biomarkers that are complementary to alpha-methylacyl-CoA racemase". The Prostate. 66 (8): 847–57. doi:10.1002/pros.20389. PMID   16491480. S2CID   25548828.
• Weng J, Wang J, Hu X, Wang F, Ittmann M, Liu M (March 2006). "PSGR2, a novel G-protein coupled receptor, is overexpressed in human prostate cancer". International Journal of Cancer. 118 (6): 1471–80. doi:10.1002/ijc.21527. PMID   16206286. S2CID   23711956.
• Weigle B, Fuessel S, Ebner R, Temme A, Schmitz M, Schwind S, et al. (September 2004). "D-GPCR: a novel putative G protein-coupled receptor overexpressed in prostate cancer and prostate". Biochemical and Biophysical Research Communications. 322 (1): 239–49. doi:10.1016/j.bbrc.2004.07.106. PMID   15313197.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Vanti WB, Nguyen T, Cheng R, Lynch KR, George SR, O'Dowd BF (May 2003). "Novel human G-protein-coupled receptors". Biochemical and Biophysical Research Communications. 305 (1): 67–71. doi:10.1016/S0006-291X(03)00709-5. PMID   12732197.
• Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, et al. (September 1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID   7566098.

External links

• OR51E1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.