OR2J3

OR2J3
Identifiers
Aliases	OR2J3 , 6M1-3, C3HEXS, HS6M1-3, OR6-16, OR6-6, OR6.3.6, ORL671, olfactory receptor family 2 subfamily J member 3
External IDs	OMIM: 615016 HomoloGene: 128270 GeneCards: OR2J3
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 29,108,058 bp [1] End 29,114,770 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve testicle n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 442186 n/a Ensembl ENSG00000204701 n/a UniProt O76001 n/a RefSeq (mRNA) NM_001005216 n/a RefSeq (protein) NP_001005216 n/a Location (UCSC) Chr 6: 29.11 – 29.11 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene. ^[3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[3]

Genetic variation

A pair of two single-nucleotide polymorphisms, both in the OR2J3 gene, strongly reduce sensitivity to the odorant cis-3-hexen-1-ol, which has a "cut grass" smell. ^[4]

Ligands

• cis-3-Hexen-1-ol ^[4]
• Cinnamaldehyde ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000204701 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Entrez Gene: OR2J3 olfactory receptor, family 2, subfamily J, member 3".
4. McRae JF, Mainland JD, Jaeger SR, Adipietro KA, Matsunami H, Newcomb RD (September 2012). "Genetic variation in the odorant receptor OR2J3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol". Chemical Senses. 37 (7): 585–93. doi:10.1093/chemse/bjs049. PMC   3408771 . PMID   22714804.
5. Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC   3990440 . PMID   24316890.

Further reading

• Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, et al. (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR2J3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.