OR1G1

OR1G1
Identifiers
Aliases	OR1G1 , OR17-130, OR17-209, OR1G2, olfactory receptor family 1 subfamily G member 1
External IDs	HomoloGene: 105311 GeneCards: OR1G1
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.3 Start 3,126,610 bp [1] End 3,127,551 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in reproductive system reproductive organ gonad n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process detection of chemical stimulus involved in sensory perception detection of chemical stimulus involved in sensory perception of smell sensory perception of smell signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8390 n/a Ensembl ENSG00000183024 n/a UniProt P47890 n/a RefSeq (mRNA) NM_003555 n/a RefSeq (protein) NP_003546 n/a Location (UCSC) Chr 17: 3.13 – 3.13 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 1G1 is a protein that in humans is encoded by the OR1G1 gene. ^{[3] [4] [5]}

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

Ligands

The OR1G1 receptor is associated with sensory sensations including "waxy", "fatty", and "rose", ^[6] and also "fruity" and "sweet". ^[7]

Compared to other olfactory receptors such as OR52D1, OR1G1 is broadly tuned to respond to odorants in different chemical classes, but it is sensitive to chain length, responding most strongly to chains of 9-10 carbons. ^[8]

Examples of agonists include:

• nonanal (strong) ^[8]
• 1-nonanol (strong) ^[8]
• 2-ethyl-1-hexanol (strong) ^[8]
• γ-decalactone (strong) ^[8]
• ethyl isobutyrate (strong) ^[8]
• 1-octanol ^[7]
• celery ketone ^[7]
• citral ^{[8] [7]}
• isoamyl acetate ^[9]

Example antagonists include:

• hexanal ^[8]
• 1-hexanol ^[8]
• cyclohexanone ^[8]

The pattern of 6-carbon antagonists compared to ~9-carbon agonists is likely explained by OR1G1 having a deep pocket at its binding site, such that the 6-carbon molecules block the opening, but do not reach the bottom of the deep pocket as required to activate the signal transduction chain. ^[8]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000183024 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, et al. (February 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Human Molecular Genetics. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID   8004088.
4. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (March 1998). "Distribution of olfactory receptor genes in the human genome". Nature Genetics. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
5. "Entrez Gene: OR1G1 olfactory receptor, family 1, subfamily G, member 1".
6. Sanz G, Thomas-Danguin T, Hamdani EH, Le Poupon C, Briand L, Pernollet JC, et al. (September 2008). "Relationships between molecular structure and perceived odor quality of ligands for a human olfactory receptor". Chemical Senses. 33 (7): 639–53. doi: 10.1093/chemse/bjn032 . PMID   18603653.
7. Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi: 10.1371/journal.pone.0093037 . PMC   3973694 . PMID   24695519.
8. Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi: 10.1093/chemse/bji002 . PMID   15647465.
9. Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, et al. (March 2005). "Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system". Chemical Senses. 30 (3): 195–207. doi: 10.1093/chemse/bji015 . PMID   15741602.

Further reading

• Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.
• Matarazzo V, Zsürger N, Guillemot JC, Clot-Faybesse O, Botto JM, Dal Farra C, et al. (October 2002). "Porcine odorant-binding protein selectively binds to a human olfactory receptor". Chemical Senses. 27 (8): 691–701. doi: 10.1093/chemse/27.8.691 . PMID   12379593.
• Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR1G1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.