P-1075

Last updated

P-1075
P-1075.svg
Clinical data
Other namesP1075
Drug class ATP-sensitive potassium channel opener; Vasodilator; Antihypertensive agent
ATC code
  • None
Identifiers
  • 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-ylguanidine
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
Chemical and physical data
Formula C12H17N5
Molar mass 231.303 g·mol−1
3D model (JSmol)
  • CCC(C)(C)N=C(NC#N)NC1=CN=CC=C1
  • InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
  • Key:HKZNADVVGXKQDL-UHFFFAOYSA-N

P-1075 is an ATP-sensitive potassium channel opener which was under development for the treatment of androgenic alopecia (pattern hair loss), arrhythmias, and ischemic heart disorders but was never marketed. [1] [2] [3] [4] [5] It has been found to stimulate cultured hair follicles and to promote hair growth in balding stump-tailed macaques. [3] [4] [5] The drug was being developed by AstraZeneca and LEO Pharma. [1] [2] It reached phase 2 clinical trials for alopecia and the preclinical research stage of development for arrhythmia and ischemic heart disorders prior to the discontinuation of its development by 2000. [1] [2] In terms of chemical structure, P-1075 is a guanidine derivative and a more potent analogue of pinacidil. [3]

See also

References

  1. 1 2 3 "P 1075". AdisInsight. 3 November 2000.
  2. 1 2 3 "Delving into the Latest Updates on P-1075 with Synapse". Synapse. 20 July 2025. Retrieved 24 July 2025.
  3. 1 2 3 Buhl AE, Conrad SJ, Waldon DJ, Brunden MN (July 1993). "Potassium channel conductance as a control mechanism in hair follicles". The Journal of Investigative Dermatology. 101 (1 Suppl): 148S –152S. doi:10.1111/1523-1747.ep12363290. PMID   8326149.
  4. 1 2 Messenger AG, Rundegren J (February 2004). "Minoxidil: mechanisms of action on hair growth". The British Journal of Dermatology. 150 (2): 186–194. doi:10.1111/j.1365-2133.2004.05785.x. PMID   14996087.
  5. 1 2 Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S (May 2012). "Minoxidil use in dermatology, side effects and recent patents". Recent Patents on Inflammation & Allergy Drug Discovery. 6 (2): 130–136. doi:10.2174/187221312800166859. PMID   22409453. Other potassium channel openers, like diazoxide [39, 40] and pinacidil [41] can cause hypertrichosis in humans as well as minoxidil. In balding macaques minoxidil, cromakalin and P-1075 (a pinacidil analogue) stimulate hair growth in about 20 weeks of topical treatment, whereas a fourth potassium channel opener, called RP49356, is not effective [42]. Harmon et al. suggested that minoxidil, diazoxide, cromakalin and pinacidil increased uptake of thymidine in hair growth cultures of mouse vibrissae follicles [43].


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