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Pronunciation | /ˌflʊərəˈlænər/ FLOOR-ə-LAN-ər |
Trade names | Bravecto, Exzolt |
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Routes of administration | By mouth |
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Pharmacokinetic data | |
Bioavailability | 20–27%; [1] reduced in the fasted state [2] |
Elimination half-life | 9.3–16.2 days [3] |
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ECHA InfoCard | 100.215.812 |
Chemical and physical data | |
Formula | C22H17Cl2F6N3O3 |
Molar mass | 556.29 g·mol−1 |
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Chirality | Racemic mixture |
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Fluralaner (INN) [4] is a systemic insecticide and acaricide that is administered orally [5] or topically. [6] The U.S. Food and Drug Administration (FDA) approved it under the trade name Bravecto for flea treatment in dogs in May 2014 [7] and Bravecto Plus as a topical treatment for cats in November 2019, [8] with warnings about possible side effects in both species. [9] The EU approved the drug in February 2014. [10] Australia approved it for the treatment and prevention of ticks and fleas on dogs in January 2015. [11] For treating mites in chickens, a solution for use in drinking water is available under the name Exzolt; [12] it was introduced by the EU in 2017. [13]
Fluralaner inhibits γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) and L-glutamate-gated chloride channels (GluCls). [14] Potency of fluralaner is comparable to fipronil (a related GABA-antagonist insecticide and acaricide). [15]
Fluralaner is being investigated to determine its ability to reduce the incidence of mosquito-borne diseases, [16] as well as bed bugs. [17] [18]
Scabies is a contagious human skin infestation by the tiny (0.2–0.45 mm) mite Sarcoptes scabiei, variety hominis. The word is from Latin: scabere, lit. 'to scratch'. The most common symptoms are severe itchiness and a pimple-like rash. Occasionally, tiny burrows may appear on the skin. In a first-ever infection, the infected person usually develops symptoms within two to six weeks. During a second infection, symptoms may begin within 24 hours. These symptoms can be present across most of the body or just certain areas such as the wrists, between fingers, or along the waistline. The head may be affected, but this is typically only in young children. The itch is often worse at night. Scratching may cause skin breakdown and an additional bacterial infection in the skin.
Mange is a type of skin disease caused by parasitic mites. Because various species of mites also infect plants, birds and reptiles, the term "mange", or colloquially "the mange", suggesting poor condition of the skin and fur due to the infection, is sometimes reserved for pathological mite-infestation of nonhuman mammals. Thus, mange includes mite-associated skin disease in domestic mammals, in livestock, and in wild mammals. Severe mange caused by mites has been observed in wild bears. Since mites belong to the arachnid subclass Acari, another term for mite infestation is acariasis.
Demodicosis, also called Demodex folliculitis in humans and demodectic mange or red mange in animals, is caused by a sensitivity to and overpopulation of Demodex spp. as the host's immune system is unable to keep the mites under control.
Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications.
Selamectin, sold under the brand name Revolution, among others, is a topical parasiticide and anthelminthic used on dogs and cats. It treats and prevents infections of heartworms, fleas, ear mites, sarcoptic mange (scabies), and certain types of ticks in dogs, and prevents heartworms, fleas, ear mites, hookworms, and roundworms in cats. It is structurally related to ivermectin and milbemycin. Selamectin is not approved for human use.
Poultry diseases occur in poultry, which are domesticated birds kept for their meat, eggs or feathers. Poultry species include the chicken, turkey, duck, goose and ostrich.
Moxidectin is an anthelmintic drug used in animals to prevent or control parasitic worms (helminths), such as heartworm and intestinal worms, in dogs, cats, horses, cattle and sheep. Moxidectin kills some of the most common internal and external parasites by selectively binding to a parasite's glutamate-gated chloride ion channels. These channels are vital to the function of invertebrate nerve and muscle cells; when moxidectin binds to the channels, it disrupts neurotransmission, resulting in paralysis and death of the parasite.
Ear mites are mites that live in the ears of animals and humans. The most commonly seen species in veterinary medicine is Otodectes cynotis. This species, despite its name, is also responsible for 90% of ear mite infections in felines.
Cheyletiella is a genus of mites that live on the skin surface of dogs, cats, and rabbits.
The cat flea is an extremely common parasitic insect whose principal host is the domestic cat, although a high proportion of the fleas found on dogs also belong to this species. This is despite the widespread existence of a separate and well-established "dog" flea, Ctenocephalides canis. Cat fleas originated in Africa but can now be found globally. As humans began domesticating cats, the prevalence of the cat flea increased and it spread throughout the world.
Dermanyssus gallinae is a haematophagous ectoparasite of poultry. It has been implicated as a vector of several major pathogenic diseases. Despite its common names, it has a wide range of hosts including several species of wild birds and mammals, including humans, where the condition it causes is called gamasoidosis. In both size and appearance, it resembles the northern fowl mite, Ornithonyssus sylviarum.
The health of domestic cats is a well studied area in veterinary medicine.
The Asian blue tick is an economically important tick that parasitises a variety of livestock and wild mammal species, especially cattle, on which it is the most economically significant ectoparasite in the world. It is known as the Australian cattle tick, southern cattle tick, Cuban tick, Madagascar blue tick, and Puerto Rican Texas fever tick.
Pyriprole is for veterinary use on dogs against external parasites such as fleas and ticks.
Metaflumizone is a semicarbazone insecticide indicated for the veterinary treatment of fleas and ticks, marketed under the brand name ProMeris. A discontinued variant of ProMeris, called ProMeris Duo or Promeris for Dogs, was indicated for canine use and was a formulated blend of metaflumizone and amitraz. The metaflumizone-only formulation is waterproof and typically remain effective for 30–45 days in a cutaneous application at the base of the neck.
Mites that infest and parasitize domestic animals cause disease and loss of production. Mites are small invertebrates, most of which are free living but some are parasitic. Mites are similar to ticks and both comprise the order Acari in the phylum Arthropoda. Mites are highly varied and their classification is complex; a simple grouping is used in this introductory article. Vernacular terms to describe diseases caused by mites include scab, mange, and scabies. Mites and ticks have substantially different biology from, and are classed separately from, insects. Mites of domestic animals cause important types of skin disease, and some mites infest other organs. Diagnosis of mite infestations can be difficult because of the small size of most mites, but understanding how mites are adapted to feed within the structure of the skin is useful.
Flea treatments are procedures used to treat flea infestations in human or animal populations. They may treat both the itching caused by bites and may remove or kill the fleas themselves.
Afoxolaner (INN) is an insecticide and acaricide that belongs to the isoxazoline chemical compound group.
Lotilaner, sold under the brand name Xdemvy, is an ectoparasiticide (anti-parasitic) medication used for the treatment of blepharitis caused by infestation by Demodex. It is used as an eye drop.
Sarolaner, sold under the brand name Simparica, is an ectoparasiticide veterinary medication for the treatment of flea and tick infestations in dogs. It is also used off-label to control sarcoptic mange and demodectic mange.