CDC42BPA

CDC42BPA
Identifiers
Aliases	CDC42BPA , MRCK, MRCKA, PK428, CDC42 binding protein kinase alpha
External IDs	OMIM: 603412 MGI: 2441841 HomoloGene: 55765 GeneCards: CDC42BPA
Gene location (Human)
Chr.	Chromosome 1 (human)
End	227,318,492 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	179,993,168 bp
RNA expression pattern
	Top expressed in
	internal globus pallidus; ; pylorus; ; tibia; ; secondary oocyte; ; external globus pallidus; ; renal medulla; ; Brodmann area 23; ; corpus callosum; ; inferior ganglion of vagus nerve; ; cardia;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; medial geniculate nucleus; ; superior colliculus; ; cerebellar vermis; ; secondary oocyte; ; supraoptic nucleus; ; lateral geniculate nucleus; ; inferior colliculus; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; nucleotide binding ; protein serine/threonine kinase activity ; protein kinase activity ; protein binding ; ATP binding ; magnesium ion binding ; metal ion binding ; identical protein binding ; kinase activity ;
Cellular component	cytoplasm ; actomyosin ; extracellular exosome ; cell leading edge ; cell-cell junction ; lamellipodium ; cell projection ; cytoskeleton ;
Biological process	protein phosphorylation ; actomyosin structure organization ; intracellular signal transduction ; cell migration ; phosphorylation ; actin cytoskeleton reorganization ; actin cytoskeleton organization ; peptidyl-threonine phosphorylation ;
	Sources:Amigo / QuickGO
Orthologs
	8476
	226751
	ENSG00000143776
	ENSMUSG00000026490
	Q5VT25
	Q3UU96
NM_003607 ; NM_014826 ; NM_001366010 ; NM_001366011 ; NM_001366019 ;
	NM_001387550 ; NM_001394014
NM_001033285 ; NM_001346804 ; NM_001346805 ; NM_001359541 ; NM_001359542 ;
	NM_001359543 ; NM_001359544 ; NM_001359545 ; NM_001359546 ; NM_001359547 ; NM_001359548 ; NM_001359549 Contents References ; External links ; Further reading ;
	NP_003598 ; NP_055641 ; NP_001352939 ; NP_001352940 ; NP_001352948
NP_001028457 ; NP_001333733 ; NP_001333734 ; NP_001346470 ; NP_001346471 ;
	NP_001346472 ; NP_001346473 ; NP_001346474 ; NP_001346475 ; NP_001346476 ; NP_001346477 ; NP_001346478
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 15, 2023

Serine/threonine-protein kinase MRCK alpha is an enzyme that in humans is encoded by the CDC42BPA gene.^[5]

The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.^[5]

Related Research Articles

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Activated CDC42 kinase 1, also known as ACK1, is an enzyme that in humans is encoded by the TNK2 gene. TNK2 gene encodes a non-receptor tyrosine kinase, ACK1, that binds to multiple receptor tyrosine kinases e.g. EGFR, MERTK, AXL, HER2 and insulin receptor (IR). ACK1 also interacts with Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined.

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Dual specificity tyrosine-phosphorylation-regulated kinase 1B is an enzyme that in humans is encoded by the DYRK1B gene.

Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.

Dystrophia myotonica WD repeat-containing protein is a protein that in humans is encoded by the DMWD gene.

BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 is a protein that in humans is encoded by the BNIP2 gene.

CDC42 binding protein kinase beta is a protein that in humans is encoded by the CDC42BPB gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143776 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026490 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

External links

Human CDC42BPA genome location and CDC42BPA gene details page in the UCSC Genome Browser .

Zhao Y, Loyer P, Li H, et al. (1997). "Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases". J. Biol. Chem. 272 (15): 10013–20. doi: 10.1074/jbc.272.15.10013 . PMID 9092543.
Leung T, Chen XQ, Tan I, et al. (1998). "Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization". Mol. Cell. Biol. 18 (1): 130–40. doi:10.1128/mcb.18.1.130. PMC 121465 . PMID 9418861.
Seki N, Ohira M, Nagase T, et al. (1998). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Res. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID 9455484.
Moncrieff CL, Bailey ME, Morrison N, Johnson KJ (1999). "Cloning and chromosomal localization of human Cdc42-binding protein kinase beta". Genomics. 57 (2): 297–300. doi:10.1006/geno.1999.5769. PMID 10198171.
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999). "Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics". Nat. Cell Biol. 1 (5): 253–9. doi:10.1038/12963. PMID 10559936. S2CID 25250183.
Ohashi K, Nagata K, Maekawa M, et al. (2000). "Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop". J. Biol. Chem. 275 (5): 3577–82. doi: 10.1074/jbc.275.5.3577 . PMID 10652353.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC 16267 . PMID 10737800.
Nakamura N, Oshiro N, Fukata Y, et al. (2000). "Phosphorylation of ERM proteins at filopodia induced by Cdc42". Genes Cells. 5 (7): 571–81. doi: 10.1046/j.1365-2443.2000.00348.x . PMID 10947843. S2CID 10022990.
Lam LT, Pham YC, Nguyen TM, Morris GE (2000). "Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart". Hum. Mol. Genet. 9 (14): 2167–73. doi: 10.1093/hmg/9.14.2167 . PMID 10958655.
Tan I, Seow KT, Lim L, Leung T (2001). "Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha". Mol. Cell. Biol. 21 (8): 2767–78. doi:10.1128/MCB.21.8.2767-2778.2001. PMC 86907 . PMID 11283256.
Sumi T, Matsumoto K, Shibuya A, Nakamura T (2001). "Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha". J. Biol. Chem. 276 (25): 23092–6. doi: 10.1074/jbc.C100196200 . PMID 11340065.
Lemercier C, Brocard MP, Puvion-Dutilleul F, et al. (2002). "Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor". J. Biol. Chem. 277 (24): 22045–52. doi: 10.1074/jbc.M201736200 . PMID 11929873.
Dong JM, Leung T, Manser E, Lim L (2003). "Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation". Eur. J. Cell Biol. 81 (4): 231–42. doi:10.1078/0171-9335-00238. PMID 12018391.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Tan I, Cheong A, Lim L, Leung T (2003). "Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity". Gene. 304: 107–15. doi:10.1016/S0378-1119(02)01185-X. PMID 12568720.
Wilkinson S, Paterson HF, Marshall CJ (2005). "Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion". Nat. Cell Biol. 7 (3): 255–61. doi:10.1038/ncb1230. PMID 15723050. S2CID 34732713.
Cmejla R, Petrak J, Cmejlova J (2006). "A novel iron responsive element in the 3'UTR of human MRCKalpha". Biochem. Biophys. Res. Commun. 341 (1): 158–66. doi:10.1016/j.bbrc.2005.12.155. PMID 16412980.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID 16710414.
Lefort K, Mandinova A, Ostano P, et al. (2007). "Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases". Genes Dev. 21 (5): 562–77. doi:10.1101/gad.1484707. PMC 1820898 . PMID 17344417.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000143776 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026490 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)".

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CDC42BPA

Contents

Related Research Articles

References

External links

Further reading