MRS8209

Last updated

MRS8209
MRS8209 structure.png
Identifiers
  • 4-[6-(cyclopentylamino)-2-iodopurin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carbonitrile
Chemical and physical data
Formula C17H19IN6O2
Molar mass 466.283 g·mol−1
3D model (JSmol)
  • O[C@H]1[C@@H](O)[C@@H]([C@H]2C[C@]21C#N)n1cnc2c1nc(I)nc2NC1CCCC1

MRS8209 is an experimental drug which acts as a potent, peripherally selective 5-HT2B receptor antagonist with high selectivity over other serotonin receptor subtypes. It has been investigated for possible applications in the treatment of heart and lung fibrosis and intestinal or vascular conditions mediated by 5-HT2B, while sparing 5-HT2B mediated activity in the brain. [1]

See also

References

  1. ↑ Tosh DK, Pavan M, Clark AA, Lammers J, Villano S, Marri S, et al. (December 2024). "Potent and Selective Human 5-HT2B Serotonin Receptor Antagonists: 4'-Cyano-(N)-methanocarba-adenosines by Synthetic Serendipity". Journal of Medicinal Chemistry. 67 (23): 21264–21291. doi:10.1021/acs.jmedchem.4c02174. PMC   11715225 . PMID   39589936.



This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.