TN-001

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TN-001
Clinical data
Other namesTN001
Routes of
administration 		Unspecified [1]
Drug class Serotonin receptor modulator; Non-hallucinogenic serotonin 5-HT2A receptor agonist; Psychoplastogen

TN-001 is a non-hallucinogenic psychoplastogen which is under development for the treatment of major depressive disorder and post-traumatic stress disorder (PTSD). [1] [2] [3] [4] [5] Its route of administration is unspecified. [1] The drug acts as a serotonin receptor modulator, including as a serotonin 5-HT2A receptor partial agonist and serotonin 5-HT2B receptor antagonist, and has been found to produce psychoplastogenic effects without inducing the head-twitch response. [1] [2] [3] [4] [5] It is being developed by Transneural Therapeutics, a spinout of CaaMTech. [1] [2] [4] As of June 2025, TN-001 is in the preclinical research stage of development. [1] [2] [3] A clinical trial is being planned. [1] The chemical structure of the drug does not yet appear to have been disclosed. [1]

See also

References

  1. 1 2 3 4 5 6 7 8 "TN 001". AdisInsight. 4 June 2025. Retrieved 24 October 2025.
  2. 1 2 3 4 "Delving into the Latest Updates on TN-001 with Synapse". Synapse. 8 May 2025. Retrieved 19 May 2025.
  3. 1 2 3 "Transneural Therapeutics". The Pharmaletter. 7 May 2025. Retrieved 19 May 2025.
  4. 1 2 3 Kuntz L (23 April 2025). "Transneural Therapeutics: A New Company to Develop Novel Neuroplastogens". Psychiatric Times. Retrieved 19 May 2025.
  5. 1 2 Slocum S, Anas N, Cogan E, Demitrack M (18 December 2025). "ACNP 64th Annual Meeting: Poster Abstracts P584-P872: P626. Preclinical behavioral and pharmacological characteristics of TN-001, a novel, non-hallucinogenic neuroplastogen for the treatment of major depressive disorder" . Neuropsychopharmacology. 51 (1). Nature Publishing Group: 410–571. doi:10.1038/s41386-025-02281-2. ISSN   1740-634X . Retrieved 8 January 2026.
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