Zinc transporter 1

Last updated
SLC30A1
Identifiers
Aliases SLC30A1 , ZNT1, ZRC1, solute carrier family 30 member 1
External IDs OMIM: 609521 MGI: 1345281 HomoloGene: 6681 GeneCards: SLC30A1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021194

NM_009579

RefSeq (protein)

NP_067017

NP_033605

Location (UCSC) Chr 1: 211.57 – 211.58 Mb Chr 1: 191.64 – 191.65 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene. [5] [6]

Contents

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn++ influx, but also Ca++ influx, thereby protecting cells from the effects of excessive cation permeation. [7]

See also

Related Research Articles

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Transmembrane channel-like protein 6 is a protein that in humans is encoded by the TMC6 gene. In vivo, TMC6 and its homolog TMC8, interact and form a complex with the zinc transporter 1 (SLC30A1) and localize mostly to the endoplasmic reticulum, but also to the nuclear membrane and Golgi apparatus.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000170385 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037434 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC   398127 . PMID   7882967.
  6. Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi: 10.1186/1471-2164-5-32 . PMC   428573 . PMID   15154973.
  7. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID   15451416.

Further reading