Zinc transporter 1

SLC30A1
Identifiers
Aliases	SLC30A1 , ZNT1, ZRC1, solute carrier family 30 member 1
External IDs	OMIM: 609521; MGI: 1345281; HomoloGene: 6681; GeneCards: SLC30A1; OMA:SLC30A1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.3 Start 211,571,568 bp [1] End 211,579,161 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H6|1 97.01 cM Start 191,638,879 bp [2] End 191,645,359 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa caput epididymis Epithelium of choroid plexus skin of thigh trabecular bone dorsal motor nucleus of vagus nerve vulva cartilage tissue corpus epididymis human penis Top expressed in placenta lip ileum renal cortex proximal tubule human kidney primary oocyte hair secondary oocyte jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function calcium channel inhibitor activity cation transmembrane transporter activity protein binding zinc ion transmembrane transporter activity Cellular component cytoplasm integral component of membrane Golgi apparatus nuclear membrane membrane T-tubule plasma membrane endoplasmic reticulum Schaffer collateral - CA1 synapse integral component of postsynaptic density membrane Biological process negative regulation of neurotransmitter secretion calcium ion import zinc ion transport cellular calcium ion homeostasis response to zinc ion cation transport in utero embryonic development ion transport negative regulation of calcium ion import detoxification of cadmium ion negative regulation of zinc ion transmembrane import zinc ion transmembrane transport cellular zinc ion homeostasis cadmium ion transmembrane transport regulation of sequestering of zinc ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7779 22782 Ensembl ENSG00000170385 ENSMUSG00000037434 UniProt Q9Y6M5 Q60738 RefSeq (mRNA) NM_021194 NM_009579 RefSeq (protein) NP_067017 NP_033605 Location (UCSC) Chr 1: 211.57 – 211.58 Mb Chr 1: 191.64 – 191.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter 1 is a protein which in humans is encoded by the SLC30A1 gene. ^{[5] [6]}

Function

SLC30A1 modulates zinc permeation through the L-type calcium channel. SLC30A1 downregulates not only Zn⁺⁺ influx, but also Ca⁺⁺ influx, thereby protecting cells from the effects of excessive cation permeation. ^[7]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000170385 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037434 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Palmiter RD, Findley SD (February 1995). "Cloning and functional characterization of a mammalian zinc transporter that confers resistance to zinc". The EMBO Journal. 14 (4): 639–49. doi:10.1002/j.1460-2075.1995.tb07042.x. PMC   398127 . PMID   7882967.
6. Seve M, Chimienti F, Devergnas S, Favier A (May 2004). "In silico identification and expression of SLC30 family genes: an expressed sequence tag data mining strategy for the characterization of zinc transporters' tissue expression". BMC Genomics. 5 (1): 32. doi: 10.1186/1471-2164-5-32 . PMC   428573 . PMID   15154973.
7. Segal D, Ohana E, Besser L, Hershfinkel M, Moran A, Sekler I (October 2004). "A role for ZnT-1 in regulating cellular cation influx". Biochemical and Biophysical Research Communications. 323 (4): 1145–50. doi:10.1016/j.bbrc.2004.08.211. PMID   15451416.

Further reading

• Guey LT, GarcÃa-Closas M, Murta-Nascimento C, et al. (2009). "Genetic Susceptibility to Distinct Bladder Cancer Subphenotypes". Eur. Urol. 57 (2): 283–292. doi:10.1016/j.eururo.2009.08.001. PMC   3220186 . PMID   19692168.
• Zhang LH, Wang X, Stoltenberg M, et al. (2008). "Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain". Brain Res. Bull. 77 (1): 55–60. doi:10.1016/j.brainresbull.2008.03.014. PMID   18639746. S2CID   33951242.
• Lovell MA, Smith JL, Xiong S, Markesbery WR (2005). "Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease". Neurotoxicity Research. 7 (4): 265–71. doi:10.1007/BF03033884. PMID   16179263. S2CID   11433.
• Zhang LY, Wang XL, Sun DX, et al. (2008). "Regulation of zinc transporters by dietary flaxseed lignan in human breast cancer xenografts". Mol. Biol. Rep. 35 (4): 595–600. doi:10.1007/s11033-007-9129-8. PMID   17786585. S2CID   2490974.
• Iguchi K, Otsuka T, Usui S, et al. (2004). "Zinc and metallothionein levels and expression of zinc transporters in androgen-independent subline of LNCaP cells". J. Androl. 25 (1): 154–61. doi:10.1002/j.1939-4640.2004.tb02771.x. PMID   14662799.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lazarczyk M, Pons C, Mendoza JA, et al. (2008). "Regulation of cellular zinc balance as a potential mechanism of EVER-mediated protection against pathogenesis by cutaneous oncogenic human papillomaviruses". J. Exp. Med. 205 (1): 35–42. doi:10.1084/jem.20071311. PMC   2234378 . PMID   18158319.
• Overbeck S, Uciechowski P, Ackland ML, et al. (2008). "Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9". J. Leukoc. Biol. 83 (2): 368–80. doi:10.1189/jlb.0307148. PMID   17971500. S2CID   21801798.
• Hosgood HD, Menashe I, He X, et al. (2009). "PTEN identified as important risk factor of chronic obstructive pulmonary disease". Respiratory Medicine. 103 (12): 1866–1870. doi:10.1016/j.rmed.2009.06.016. PMC   2783799 . PMID   19625176.
• Hosgood HD, Menashe I, Shen M, et al. (2008). "Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway". Carcinogenesis. 29 (10): 1938–43. doi:10.1093/carcin/bgn178. PMC   2722857 . PMID   18676680.
• Etzion Y, Ganiel A, Beharier O, et al. (2008). "Correlation between atrial ZnT-1 expression and atrial fibrillation in humans: a pilot study". J. Cardiovasc. Electrophysiol. 19 (2): 157–64. doi:10.1111/j.1540-8167.2007.01008.x. PMID   17971132. S2CID   8430908.
• Barbe L, Lundberg E, Oksvold P, et al. (2008). "Toward a confocal subcellular atlas of the human proteome". Mol. Cell. Proteomics. 7 (3): 499–508. doi: 10.1074/mcp.M700325-MCP200 . PMID   18029348.