Excitatory amino acid transporter 5

SLC1A7
Identifiers
Aliases	SLC1A7 , AAAT, EAAT5, solute carrier family 1 member 7
External IDs	OMIM: 604471 MGI: 2444087 HomoloGene: 21327 GeneCards: SLC1A7
Gene location (Human)
Chr.	Chromosome 1 (human)
End	53,142,638 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	107,870,729 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; jejunal mucosa; ; gallbladder; ; tibial nerve; ; right coronary artery; ; left uterine tube; ; duodenum; ; left coronary artery; ; canal of the cervix; ; ascending aorta;
	Top expressed in
	outer nuclear layer; ; retinal pigment epithelium; ; inner nuclear layer; ; left lobe of liver; ; spermatid; ; skin of abdomen; ; pituitary gland; ; testicle; ; carotid body; ; heart;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity ; L-glutamate transmembrane transporter activity ; amino acid transmembrane transporter activity ; high-affinity glutamate transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; presynapse ;
Biological process	glutamate secretion ; ion transport ; dicarboxylic acid transport ; transmembrane transport ; amino acid transmembrane transport ; L-glutamate transmembrane transport ; neurotransmitter uptake ; neurotransmitter reuptake ;
	Sources:Amigo / QuickGO
Orthologs
	6512
	242607
	ENSG00000162383
	ENSMUSG00000008932
	O00341
	Q8JZR4
	NM_001287595 ; NM_001287596 ; NM_001287597 ; NM_006671
	NM_146255
	NP_001274524 ; NP_001274525 ; NP_001274526 ; NP_006662
	NP_666367
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 22, 2023

Excitatory amino-acid transporter 5 (EAAT5) is a protein that in humans is encoded by the SLC1A7 gene.^[5]^[6]

EAAT5 is expressed predominantly in the retina, has high affinity for the excitatory amino acid L-glutamate. When stimulated by this amino acid, EAAT5 conducts chloride ions.^[6]

Related Research Articles

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Neutral amino acid transporter A is a protein that in humans is encoded by the SLC1A4 gene.

Sodium- and chloride-dependent taurine transporter is a protein that in humans is encoded by the SLC6A6 gene.

Y+L amino acid transporter 1 is a protein that in humans is encoded by the SLC7A7 gene.

Very long-chain acyl-CoA synthetase is an enzyme that in humans is encoded by the SLC27A2 gene.

Cationic amino acid transporter 3 is a protein that in humans is encoded by the SLC7A3 gene.

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

Sodium-dependent phosphate transporter 2 is a protein that in humans is encoded by the SLC20A2 gene.

Sodium-coupled neutral amino acid transporter 1 is a protein that in humans is encoded by the SLC38A1 gene.

Long-chain fatty acid transport protein 6 is a protein that in humans is encoded by the SLC27A6 gene.

Bestrophin-2 is a protein that in humans is encoded by the BEST2 gene.

Secreted frizzled-related protein 5 is a protein that in humans is encoded by the SFRP5 gene.

Large neutral amino acids transporter small subunit 3 is a protein that in humans is encoded by the SLC43A1 gene.

Long-chain fatty acid transport protein 3 is a protein that in humans is encoded by the SLC27A3 gene.

Solute carrier family 6, member 18 also known as SLC6A18 is a protein which in humans is encoded by the SLC6A18 gene.

Asc-type amino acid transporter 1 (Asc-1) is a protein that in humans is encoded by the SLC7A10 gene.

Vesicular glutamate transporter 3 (VGLUT3) is a protein that in humans is encoded by the SLC17A8 gene.

An excitatory amino acid reuptake inhibitor (EAARI) is a type of drug which inhibits the reuptake of the excitatory neurotransmitters glutamate and aspartate by blocking one or more of the excitatory amino acid transporters (EAATs).

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162383 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008932 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: solute carrier family 1 (glutamate transporter)".
1 2 Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (April 1997). "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. Bibcode:1997PNAS...94.4155A. doi: 10.1073/pnas.94.8.4155 . PMC 20584 . PMID 9108121.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Wistow G, Bernstein SL, Ray S, et al. (2002). "Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium". Mol. Vis. 8: 185–95. PMID 12107412.
Boehmer C, Rajamanickam J, Schniepp R, et al. (2005). "Regulation of the excitatory amino acid transporter EAAT5 by the serum and glucocorticoid dependent kinases SGK1 and SGK3". Biochem. Biophys. Res. Commun. 329 (2): 738–42. doi:10.1016/j.bbrc.2005.02.035. PMID 15737648.
Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. S2CID 44524739.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162383 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000008932 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: solute carrier family 1 (glutamate transporter)".

[pmid9108121-6] 1 2 Arriza JL, Eliasof S, Kavanaugh MP, Amara SG (April 1997). "Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance". Proc. Natl. Acad. Sci. U.S.A. 94 (8): 4155–60. Bibcode:1997PNAS...94.4155A. doi: 10.1073/pnas.94.8.4155 . PMC 20584 . PMID 9108121.

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Excitatory amino acid transporter 5

Related Research Articles

References

Further reading