Nexeridine

Last updated
Nexeridine
Nexeridine.svg
Clinical data
ATC code
  • None
Identifiers
  • 1-[1-(Dimethylamino)-2-propanyl]-2-phenylcyclohexyl acetate
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C19H29NO2
Molar mass 303.446 g·mol−1
3D model (JSmol)
  • CN(C)C[C@@H](C)[C@@]1(OC(=O)C)CCCC[C@H]1c1ccccc1
  • InChI=1S/C19H29NO2/c1-15(14-20(3)4)19(22-16(2)21)13-9-8-12-18(19)17-10-6-5-7-11-17/h5-7,10-11,15,18H,8-9,12-14H2,1-4H3
  • Key:TVQPXLMQOZWEBA-UHFFFAOYSA-N

Nexeridine (INN; USAN: nexeridine hydrochloride; code name Compound 673-082) is an opioid analgesic with a similar structure to those of pethidine and tramadol. [1] [2] [3] [4] It was synthesized and assayed in 1975 but was never marketed. [2] The active isomer is (1R,2S)-1-[(2R)-1-(dimethylamino)-2-propanyl]-2-phenylcyclohexyl acetate. [5]

References

  1. ↑ US 3974157,"1-(Amino-alkyl)-2-aryl-cyclohexane alcohols and esters"
  2. 1 2 Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1417–. ISBN   978-0-412-46630-4.
  3. ↑ Kar A (1 January 2005). Medicinal Chemistry. New Age International. pp. 268–269. ISBN   978-81-224-1565-0.
  4. ↑ Unlisted Drugs, Volumes 27-28. Pharmaceutical Section, Special Libraries Association. 1975.
  5. ↑ "(1R,2S)-1-[(2R)-1-(Dimethylamino)-2-propanyl]-2-phenylcyclohexyl acetate hydrochloride (1:1)". ChemSpider.


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