Excitatory amino acid transporter 4

SLC1A6
Identifiers
Aliases	SLC1A6 , EAAT4, solute carrier family 1 member 6
External IDs	OMIM: 600637; MGI: 1096331; HomoloGene: 21055; GeneCards: SLC1A6; OMA:SLC1A6 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.12 Start 14,950,033 bp [1] End 15,022,990 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 C1|10 39.72 cM Start 78,616,330 bp [2] End 78,650,599 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum endothelial cell left testis right testis paraflocculus of cerebellum skin of thigh cerebellar vermis nucleus accumbens oocyte caudate nucleus Top expressed in cerebellar vermis lobe of cerebellum dorsomedial hypothalamic nucleus lumbar subsegment of spinal cord ventromedial nucleus inferior colliculi superior colliculus dentate gyrus of hippocampal formation granule cell lateral hypothalamus ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function L-aspartate transmembrane transporter activity symporter activity L-glutamate transmembrane transporter activity amino acid transmembrane transporter activity high-affinity glutamate transmembrane transporter activity metal ion binding Cellular component integral component of membrane Golgi apparatus membrane intermediate filament cytoskeleton integral component of plasma membrane plasma membrane glutamatergic synapse integral component of presynaptic membrane Biological process chemical synaptic transmission regulation of membrane potential ion transport glutamate secretion aspartate transmembrane transport L-glutamate transmembrane transport L-glutamate import across plasma membrane amino acid transport L-aspartate transmembrane transport neurotransmitter uptake transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6511 20513 Ensembl ENSG00000105143 ENSMUSG00000005357 UniProt P48664 O35544 RefSeq (mRNA) NM_001272087 NM_001272088 NM_005071 NM_001384669 NM_001384670 NM_001384671 NM_009200 RefSeq (protein) NP_001259016 NP_001259017 NP_005062 NP_033226 Location (UCSC) Chr 19: 14.95 – 15.02 Mb Chr 10: 78.62 – 78.65 Mb PubMed search [3] [4]
Wikidata
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Excitatory amino-acid transporter 4 (EAAT4) is a protein that in humans is encoded by the SLC1A6 gene. ^{[5] [6]}

EAAT4 is expressed predominantly in the cerebellum, has high affinity for the excitatory amino acids L-aspartate and L-glutamate. When stimulated by these amino acids, EAAT4 conducts chloride ions. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000105143 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000005357 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: solute carrier family 1 (high affinity aspartate/glutamate transporter)".
6. Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG (June 1995). "An excitatory amino-acid transporter with properties of a ligand-gated chloride channel". Nature. 375 (6532): 599–603. Bibcode:1995Natur.375..599F. doi:10.1038/375599a0. PMID   7791878. S2CID   4334983.

Further reading

• Deng X, Shibata H, Takeuchi N, et al. (2007). "Association study of polymorphisms in the glutamate transporter genes SLC1A1, SLC1A3, and SLC1A6 with schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 144B (3): 271–8. doi:10.1002/ajmg.b.30351. PMID   17221839. S2CID   42347750.
• Need AC, Keefe RS, Ge D, et al. (2009). "Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis". Eur. J. Hum. Genet. 17 (7): 946–57. doi:10.1038/ejhg.2008.264. PMC   2986499 . PMID   19156168.
• Poulsen MV, Vandenberg RJ (2001). "Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4". J. Physiol. 534 (Pt 1): 159–67. doi:10.1111/j.1469-7793.2001.00159.x. PMC   2278676 . PMID   11432999.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.
• Koch HP, Brown RL, Larsson HP (2007). "The glutamate-activated anion conductance in excitatory amino acid transporters is gated independently by the individual subunits". J. Neurosci. 27 (11): 2943–7. doi:10.1523/JNEUROSCI.0118-07.2007. PMC   2435202 . PMID   17360917.
• Jackson M, Song W, Liu MY, et al. (2001). "Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins". Nature. 410 (6824): 89–93. Bibcode:2001Natur.410...89J. doi: 10.1038/35065091 . PMID   11242047. S2CID   4381210.
• Rajamanickam J, Palmada M, Lang F, Boehmer C (2007). "EAAT4 phosphorylation at the SGK1 consensus site is required for transport modulation by the kinase". J. Neurochem. 102 (3): 858–66. doi: 10.1111/j.1471-4159.2007.04585.x . PMID   17442044. S2CID   30779935.
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi: 10.1002/ajmg.b.30902 . PMID   19086053. S2CID   44524739.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19" (PDF). Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824. S2CID   4420825.