Ammonium ferric citrate

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Ammonium ferric citrate
Ammoniumeisen(III)-citrat V7.svg
Structure of ammonium ferric citrate
Ammonium ferric citrate dihydrate structure.png
Crystal structure of [NH4]5[Fe(C6H4O7)2]·2H2O [1]
Names
IUPAC name
2-Hydroxypropane-1,2,3-tricarboxylate, ammonium iron(3+) salt
Other names
Ferric ammonium citrate
Ammonium iron(III) citrate
Ammonium ferric citrate
Iron ammonium citrate
FerriSeltz
Identifiers
ChEBI
ChEMBL
ECHA InfoCard 100.013.351 OOjs UI icon edit-ltr-progressive.svg
EC Number
  • 214-686-6
E number E381 (antioxidants, ...)
KEGG
PubChem CID
UNII
  • InChI=1S/C6H8O7.Fe.H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;1H3/q;+3;/p-2 Yes check.svgY
    Key: FRHBOQMZUOWXQL-UHFFFAOYSA-L Yes check.svgY
  • InChI=1/C6H8O7.Fe.H3N/c7-3(8)1-6(13,5(11)12)2-4(9)10;;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);;1H3/q;+3;/p-2
    Key: FRHBOQMZUOWXQL-NUQVWONBAA
Properties
C6H8O7xFe3+yNH3
Appearanceyellow crystals
Pharmacology
V08CA07 ( WHO )
Hazards
Safety data sheet (SDS)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Ammonium ferric citrate (also known as ferric ammonium citrate or ammoniacal ferrous citrate) has the formula [NH4]y[Fex(C6H4O7)]. The iron in this compound is trivalent. All three carboxyl groups and the central hydroxyl group of citric acid are deprotonated. A distinguishing feature of this compound is that it is very soluble in water, in contrast to ferric citrate which is not very soluble. [3]

In its crystal structure each moiety of citric acid has lost four protons. The deprotonated hydroxyl group and two of the carboxylate groups ligate to the ferric center, while the third carboxylate group coordinates with the ammonium. [1]

Uses

Ammonium ferric citrate has a range of uses, including:

See also

Related Research Articles

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An acid is a molecule or ion capable of either donating a proton (i.e. hydrogen ion, H+), known as a Brønsted–Lowry acid, or forming a covalent bond with an electron pair, known as a Lewis acid.

<span class="mw-page-title-main">Chemistry of ascorbic acid</span> Chemical compound

Ascorbic acid is an organic compound with formula C
6
H
8
O
6
, originally called hexuronic acid. It is a white solid, but impure samples can appear yellowish. It dissolves freely in water to give mildly acidic solutions. It is a mild reducing agent.

<span class="mw-page-title-main">Carboxylic acid</span> Organic compound containing a –C(=O)OH group

In organic chemistry, a carboxylic acid is an organic acid that contains a carboxyl group attached to an R-group. The general formula of a carboxylic acid is often written as R−COOH or R−CO2H, sometimes as R−C(O)OH with R referring to an organyl group, or hydrogen, or other groups. Carboxylic acids occur widely. Important examples include the amino acids and fatty acids. Deprotonation of a carboxylic acid gives a carboxylate anion.

<span class="mw-page-title-main">Citric acid</span> Weak organic acid

Citric acid is an organic compound with the skeletal formula HOC(CO2H)(CH2CO2H)2. It is a colorless weak organic acid. It occurs naturally in citrus fruits. In biochemistry, it is an intermediate in the citric acid cycle, which occurs in the metabolism of all aerobic organisms.

<span class="mw-page-title-main">Malic acid</span> Dicarboxylic acid responsible for apple acidity

Malic acid is an organic compound with the molecular formula HO2CCH(OH)CH2CO2H. It is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive. Malic acid has two stereoisomeric forms, though only the L-isomer exists naturally. The salts and esters of malic acid are known as malates. The malate anion is a metabolic intermediate in the citric acid cycle.

Iron(III) chloride describes the inorganic compounds with the formula FeCl3(H2O)x. Also called ferric chloride, these compounds are some of the most important and commonplace compounds of iron. They are available both in anhydrous and in hydrated forms, which are both hygroscopic. They feature iron in its +3 oxidation state. The anhydrous derivative is a Lewis acid, while all forms are mild oxidizing agents. It is used as a water cleaner and as an etchant for metals.

<span class="mw-page-title-main">Oxaloacetic acid</span> Organic compound

Oxaloacetic acid (also known as oxalacetic acid or OAA) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals. It takes part in gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, fatty acid synthesis and the citric acid cycle.

<span class="mw-page-title-main">Ammonium sulfate</span> Chemical compound

Ammonium sulfate (American English and international scientific usage; ammonium sulphate in British English); (NH4)2SO4, is an inorganic salt with a number of commercial uses. The most common use is as a soil fertilizer. It contains 21% nitrogen and 24% sulfur.

<span class="mw-page-title-main">Sulfamic acid</span> Chemical compound

Sulfamic acid, also known as amidosulfonic acid, amidosulfuric acid, aminosulfonic acid, sulphamic acid and sulfamidic acid, is a molecular compound with the formula H3NSO3. This colourless, water-soluble compound finds many applications. Sulfamic acid melts at 205 °C before decomposing at higher temperatures to water, sulfur trioxide, sulfur dioxide and nitrogen.

<span class="mw-page-title-main">Iron(II) sulfide</span> Chemical compound

Iron(II) sulfide or ferrous sulfide is one of a family of chemical compounds and minerals with the approximate formula FeS. Iron sulfides are often iron-deficient non-stoichiometric. All are black, water-insoluble solids.

<span class="mw-page-title-main">Ammonium dichromate</span> Chemical compound

Ammonium dichromate is an inorganic compound with the formula (NH4)2Cr2O7. In this compound, as in all chromates and dichromates, chromium is in a +6 oxidation state, commonly known as hexavalent chromium. It is a salt consisting of ammonium ions and dichromate ions.

<span class="mw-page-title-main">Magnesium citrate</span> Chemical compound

Magnesium citrates are metal-organic compounds formed from citrate and magnesium ions. They are salts. One form is the 1:1 magnesium preparation in salt form with citric acid in a 1:1 ratio. It contains 11.33% magnesium by weight. Magnesium citrate is used medicinally as a saline laxative and to completely empty the bowel prior to a major surgery or colonoscopy. It is available without a prescription, both as a generic and under various brand names. It is also used in the pill form as a magnesium dietary supplement. As a food additive, magnesium citrate is used to regulate acidity and is known as E number E345.

Magnesium aspartate is a magnesium salt of aspartic acid. It is used as a mineral supplement, and as an ingredient in manufacturing of cosmetics and household products.

<span class="mw-page-title-main">Ammonium iron(III) sulfate</span> Chemical compound

Ammonium iron(III) sulfate, NH4Fe(SO4)2·12 H2O, or NH4[Fe(H2O)6](SO4)2·6 H2O, also known as ferric ammonium sulfate (FAS) or iron alum, is a double salt in the class of alums, which consists of compounds with the general formula AB(SO4)2 · 12 H2O. It has the appearance of weakly violet, octahedrical crystals. There has been some discussion regarding the origin of the crystals' color, with some ascribing it to impurities in the compound, and others claiming it to be a property of the crystal itself.

<span class="mw-page-title-main">Iron(II) citrate</span> Chemical compound

Ferrous citrate, also known as iron(II) citrate or iron(2+) citrate, describes coordination complexes containing citrate anions with Fe2+ formed in aqueous solution. Although a number of complexes are possible (or even likely), only one complex has been crystallized. That complex is the coordination polymer with the formula [Fe(H2O)6]2+{[Fe(C6H5O7)(H2O)]}2.2H2O, where C6H5O73- is HOC(CH2CO2)2(CO2, i.e., the triple conjugate base of citric acid wherein the three carboxylic acid groups are ionized. Ferrous citrates are all paramagnetic, reflecting the weak crystal field of the carboxylate ligands.

<span class="mw-page-title-main">Ammonium sulfite</span> Chemical compound

Ammonium sulfite is the ammonium salt of sulfurous acid with the chemical formula (NH4)2SO3.

<span class="mw-page-title-main">Ammonium oxalate</span> Chemical compound

Ammonium oxalate is a chemical compound with the chemical formula [NH4]2C2O4. Its formula is often written as (NH4)2C2O4 or (COONH4)2. It is an ammonium salt of oxalic acid. It consists of ammonium cations ([NH4]+) and oxalate anions (C2O2−4). The structure of ammonium oxalate is ([NH4]+)2[C2O4]2−. Ammonium oxalate sometimes comes as a monohydrate ([NH4]2C2O4·H2O). It is a colorless or white salt under standard conditions and is odorless and non-volatile. It occurs in many plants and vegetables.

<span class="mw-page-title-main">Iron(III) citrate</span> Chemical compound

Ferric citrate or iron(III) citrate describes any of several complexes formed upon binding any of the several conjugate bases derived from citric acid with ferric ions. Most of these complexes are orange or red-brown. They contain two or more Fe(III) centers.

<span class="mw-page-title-main">Aluminium citrate</span> Chemical compound

Aluminium citrate is a chemical compound with the chemical formula AlC
6
H
5
O
7
. This white, crystalline salt is produced by mixing aluminium chloride hexahydrate and citric acid.

References

  1. 1 2 Matzapetakis, M.; Raptopoulou, C. P.; Tsohos, A.; Papaefthymiou, V.; Moon, N.; Salifoglou, A. (1998). "Synthesis, Spectroscopic and Structural Characterization of the First Mononuclear, Water Soluble Iron−Citrate Complex, (NH4)5Fe(C6H4O7)2·2H2O". J. Am. Chem. Soc. 120 (50): 13266–13267. doi:10.1021/ja9807035.
  2. "KEGG DRUG: Ferric ammonium citrate".
  3. PubChem. "Ammonium ferric citrate". pubchem.ncbi.nlm.nih.gov. Retrieved 4 October 2022.
  4. "AMMONIUM FERRIC CITRATE". World Health Organization. Retrieved 21 September 2022.
  5. 1 2 "Ammonium Ferric Citrate Properties, Molecular Formula, Applications – WorldOfChemicals". worldofchemicals.com. Retrieved 17 October 2022.
  6. Aryal, Sagar (28 November 2018). "Kligler's Iron Agar Test – Procedure, Uses and Interpretation". MicrobiologyInfo.com. Retrieved 5 November 2021.
  7. Budavari, Susan, ed. (2001), The Merck Index: An Encyclopedia of Chemicals, Drugs, and Biologicals (13th ed.), Merck, ISBN   0911910131