SIK1

SIK1
Identifiers
Aliases	SIK1 , MSK, SIK, SNF1LK, EIEE30, salt inducible kinase 1, SIK-1, SIK1B, DEE30
External IDs	OMIM: 605705; MGI: 104754; HomoloGene: 136094; GeneCards: SIK1; OMA:SIK1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q22.3 Start 43,414,483 bp [1] End 43,427,131 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 17.25 cM Start 32,063,224 bp [2] End 32,074,778 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa skin of abdomen skin of leg gallbladder bone marrow cells left ovary left uterine tube vagina right ovary upper lobe of left lung Top expressed in granulocyte decidua yolk sac lip muscle of thigh genital tubercle proximal tubule tail of embryo esophagus endocardial cushion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity cAMP response element binding protein binding 14-3-3 protein binding metal ion binding kinase activity protein serine/threonine kinase activity protein binding ATP binding protein kinase binding magnesium ion binding Cellular component cytoplasm nucleus nucleotide-activated protein kinase complex Biological process regulation of myotube differentiation cell differentiation intracellular signal transduction phosphorylation regulation of sodium ion transport rhythmic process cardiac muscle cell differentiation negative regulation of triglyceride biosynthetic process negative regulation of CREB transcription factor activity multicellular organism development protein phosphorylation negative regulation of gluconeogenesis regulation of mitotic cell cycle regulation of cell differentiation protein autophosphorylation cell cycle positive regulation of anoikis entrainment of circadian clock by photoperiod cellular response to hormone stimulus negative regulation of TOR signaling cellular response to glucose starvation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 150094 17691 Ensembl ENSG00000142178 ENSMUSG00000024042 UniProt P57059 Q60670 RefSeq (mRNA) NM_173354 NM_010831 RefSeq (protein) NP_001307572 NP_034961 Location (UCSC) Chr 21: 43.41 – 43.43 Mb Chr 17: 32.06 – 32.07 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase SIK1 is an enzyme that in humans is encoded by the SIK1 gene. ^{[5] [6]}

See also

• Serine/threonine-protein kinase
• SIK2

References

1. GRCh38: Ensembl release 89: ENSG00000142178 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024042 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ruiz JC, Conlon FL, Robertson EJ (Apr 1995). "Identification of novel protein kinases expressed in the myocardium of the developing mouse heart". Mech Dev. 48 (3): 153–64. doi:10.1016/0925-4773(94)90056-6. PMID   7893599. S2CID   24459160.
6. "Entrez Gene: SNF1LK SNF1-like kinase".

Further reading

• Takemori H, Kajimura J, Okamoto M (2007). "TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain". FEBS J. 274 (13): 3202–9. doi: 10.1111/j.1742-4658.2007.05889.x . PMID   17565599. S2CID   30323449.
• Al-Hakim AK, Göransson O, Deak M, et al. (2006). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". J. Cell Sci. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID   16306228. S2CID   17404931.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Lizcano JM, Göransson O, Toth R, et al. (2005). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". EMBO J. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC   381014 . PMID   14976552.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi: 10.1038/35012518 . PMID   10830953.
• Nishimura Y, Hayashi M, Inada H, Tanaka T (1999). "Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins". Biochem. Biophys. Res. Commun. 254 (1): 21–6. doi:10.1006/bbrc.1998.9876. PMID   9920726.