SMG1

For the video game, see Super Mario Galaxy.

SMG1
Identifiers
Aliases	SMG1 , 61E3.4, ATX, LIP, nonsense mediated mRNA decay associated PI3K related kinase, SMG1 nonsense mediated mRNA decay associated PI3K related kinase
External IDs	OMIM: 607032; MGI: 1919742; HomoloGene: 56697; GeneCards: SMG1; OMA:SMG1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16p12.3 Start 18,804,860 bp [1] End 18,926,408 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F1 Start 117,730,531 bp [2] End 117,842,893 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh sural nerve epithelium of colon skin of hip Achilles tendon epithelium of nasopharynx parietal pleura mucosa of sigmoid colon visceral pleura jejunal mucosa Top expressed in tail of embryo genital tubercle lobe of cerebellum cerebellar vermis mesenteric lymph nodes medullary collecting duct Rostral migratory stream renal corpuscle neural layer of retina spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function telomeric DNA binding ATP binding protein kinase activity protein binding kinase activity metal ion binding nucleotide binding transferase activity protein serine/threonine kinase activity RNA binding Cellular component nucleus cytosol cytoplasm nucleoplasm Biological process response to stress mRNA export from nucleus nuclear-transcribed mRNA catabolic process, nonsense-mediated decay peptidyl-serine phosphorylation phosphatidylinositol phosphate biosynthetic process cellular response to DNA damage stimulus protein autophosphorylation phosphorylation regulation of telomere maintenance DNA repair regulation of response to DNA damage stimulus protein phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23049 233789 Ensembl ENSG00000157106 ENSMUSG00000030655 UniProt Q96Q15 Q8BKX6 RefSeq (mRNA) NM_015092 NM_001031814 NM_177180 RefSeq (protein) NP_055907 NP_001026984 Location (UCSC) Chr 16: 18.8 – 18.93 Mb Chr 7: 117.73 – 117.84 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase SMG1 is an enzyme that in humans is encoded by the SMG1 gene. ^{[5] [6] [7] [8]} SMG1 belongs to the phosphatidylinositol 3-kinase-related kinase protein family.

Function

This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined. ^[8]

Interactions

SMG1 (gene) has been shown to interact with PRKCI ^[9] and UPF1. ^[10]

References

1. GRCh38: Ensembl release 89: ENSG00000157106 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030655 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
6. Denning G, Jamieson L, Maquat LE, Thompson EA, Fields AP (June 2001). "Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein". J. Biol. Chem. 276 (25): 22709–14. doi: 10.1074/jbc.C100144200 . PMID   11331269.
7. Morita T, Yamashita A, Kashima I, Ogata K, Ishiura S, Ohno S (March 2007). "Distant N- and C-terminal domains are required for intrinsic kinase activity of SMG-1, a critical component of nonsense-mediated mRNA decay". J. Biol. Chem. 282 (11): 7799–808. doi: 10.1074/jbc.M610159200 . PMID   17229728.
8. "Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1".
9. Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (January 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. doi:10.1128/mcb.16.1.105. PMC   230983 . PMID   8524286.
10. Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (September 2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC   312771 . PMID   11544179.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. CiteSeerX   10.1.1.500.923 . doi:10.1093/dnares/9.3.99. PMID   12168954.
• Abraham RT (2005). "The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways". DNA Repair (Amst.). 3 (8–9): 919–25. doi:10.1016/j.dnarep.2004.04.003. PMID   15279777.
• Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Mol. Cell. Biol. 16 (1): 105–14. doi:10.1128/MCB.16.1.105. PMC   230983 . PMID   8524286.
• Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Mol. Cell. Biol. 18 (5): 3069–80. doi:10.1128/mcb.18.5.3069. PMC   110686 . PMID   9566925.
• Carmeliet P, Lampugnani MG, Moons L, Breviario F, Compernolle V, Bono F, Balconi G, Spagnuolo R, Oosthuyse B, Dewerchin M, Zanetti A, Angellilo A, Mattot V, Nuyens D, Lutgens E, Clotman F, de Ruiter MC, Gittenberger-de Groot A, Poelmann R, Lupu F, Herbert JM, Collen D, Dejana E (1999). "Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis". Cell. 98 (2): 147–57. doi: 10.1016/S0092-8674(00)81010-7 . PMID   10428027. S2CID   2668221.
• Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID   10493829.
• Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Yamashita A, Ohnishi T, Kashima I, Taya Y, Ohno S (2001). "Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay". Genes Dev. 15 (17): 2215–28. doi:10.1101/gad.913001. PMC   312771 . PMID   11544179.
• Eichler EE, Johnson ME, Alkan C, Tuzun E, Sahinalp C, Misceo D, Archidiacono N, Rocchi M (2002). "Divergent origins and concerted expansion of two segmental duplications on chromosome 16". J. Hered. 92 (6): 462–8. doi: 10.1093/jhered/92.6.462 . PMID   11948212.
• Chiu SY, Serin G, Ohara O, Maquat LE (2003). "Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1". RNA. 9 (1): 77–87. doi:10.1261/rna.2137903. PMC   1370372 . PMID   12554878.
• Ohnishi T, Yamashita A, Kashima I, Schell T, Anders KR, Grimson A, Hachiya T, Hentze MW, Anderson P, Ohno S (2003). "Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7". Mol. Cell. 12 (5): 1187–200. doi: 10.1016/S1097-2765(03)00443-X . PMID   14636577.
• Brumbaugh KM, Otterness DM, Geisen C, Oliveira V, Brognard J, Li X, Lejeune F, Tibbetts RS, Maquat LE, Abraham RT (2004). "The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells". Mol. Cell. 14 (5): 585–98. doi: 10.1016/j.molcel.2004.05.005 . PMID   15175154.
• Kashima I, Yamashita A, Izumi N, Kataoka N, Morishita R, Hoshino S, Ohno M, Dreyfuss G, Ohno S (2006). "Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay". Genes Dev. 20 (3): 355–67. doi:10.1101/gad.1389006. PMC   1361706 . PMID   16452507.
• Azzalin CM, Lingner J (2006). "The human RNA surveillance factor UPF1 is required for S phase progression and genome stability". Curr. Biol. 16 (4): 433–9. Bibcode:2006CBio...16..433A. doi: 10.1016/j.cub.2006.01.018 . PMID   16488880. S2CID   17197870.