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Trade names | Lumark, EndolucinBeta, Illuzyce |
AHFS/Drugs.com | Lumark UK Drug Information EndolucinBeta UK Drug Information |
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Chemical and physical data | |
Formula | Cl3Lu |
Molar mass | 281.32 g·mol−1 |
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Lutetium (177Lu) chloride is a radioactive compound used for the radiolabeling of pharmaceutical molecules, aimed either as an anti-cancer therapy or for scintigraphy (medical imaging). [5] [6] It is an isotopomer of lutetium(III) chloride containing the radioactive isotope 177Lu, which undergoes beta decay with a half-life of 6.64 days. [8]
Lutetium (177Lu) chloride is a radiopharmaceutical precursor and is not intended for direct use in patients. [5] It is used for the radiolabeling of carrier molecules specifically developed for reaching certain target tissues or organs in the body. The molecules labeled in this way are used as cancer therapeutics or for scintigraphy, a form of medical imaging. [5] 177Lu has been used with both small molecule therapeutic agents (such as 177Lu-DOTATATE) and antibodies for targeted cancer therapy [9] [10]
Medicines radiolabeled with lutetium (177Lu) chloride must not be used in women unless pregnancy has been ruled out. [5]
The most common side effects are anaemia (low red blood cell counts), thrombocytopenia (low blood platelet counts), leucopenia (low white blood cell counts), lymphopenia (low levels of lymphocytes, a particular type of white blood cell), nausea (feeling sick), vomiting and mild and temporary hair loss. [5]
Lutetium (177Lu) chloride (Lumark) was approved for use in the European Union in June 2015. [5] Lutetium (177Lu) chloride (EndolucinBeta) was approved for use in the European Union in July 2016. [6]
In July 2022, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion, recommending the granting of a marketing authorization for the medicinal product Illuzyce, a radiopharmaceutical precursor. [11] Illuzyce is not intended for direct use in patients and must be used only for the radiolabelling of carrier medicines that have been specifically developed and authorized for radiolabelling with lutetium (177Lu) chloride. [11] The applicant for this medicinal product is Billev Pharma ApS. [11] Illuzyce was approved for medical use in the European Union in September 2022. [7]
Teriparatide, sold under the brand name Forteo, is a form of parathyroid hormone (PTH) consisting of the first (N-terminus) 34 amino acids, which is the bioactive portion of the hormone. It is an effective anabolic agent used in the treatment of some forms of osteoporosis. Teriparatide is a recombinant human parathyroid hormone analog. It has an identical sequence to the 34 N-terminal amino acids of the 84-amino acid human parathyroid hormone.
Naturally occurring lutetium (71Lu) is composed of one stable isotope 175Lu and one long-lived radioisotope, 176Lu with a half-life of 37 billion years. Forty radioisotopes have been characterized, with the most stable, besides 176Lu, being 174Lu with a half-life of 3.31 years, and 173Lu with a half-life of 1.37 years. All of the remaining radioactive isotopes have half-lives that are less than 9 days, and the majority of these have half-lives that are less than half an hour. This element also has 18 meta states, with the most stable being 177mLu, 174mLu and 178mLu.
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Indacaterol/glycopyrronium bromide/mometasone, sold under the brand name Enerzair Breezhaler among others, is an inhalable fixed-dose combination medication for the treatment of asthma. It contains indacaterol as acetate, glycopyrronium bromide, and mometasone furoate.
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