Finrozole

Finrozole

Names
Preferred IUPAC name 4-[(1R,2S)-3-(4-Fluorophenyl)-2-hydroxy-1-(1H-1,2,4-triazol-1-yl)propyl]benzonitrile
Identifiers
CAS Number	160146-17-8  Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL2218882
ChemSpider	5293483
ECHA InfoCard	100.219.051
PubChem CID	6918277
UNII	40028KHQ6B  Y
CompTox Dashboard (EPA)	DTXSID90166806
InChI InChI=1S/C18H15FN4O/c19-16-7-3-13(4-8-16)9-17(24)18(23-12-21-11-22-23)15-5-1-14(10-20)2-6-15/h1-8,11-12,17-18,24H,9H2/t17-,18+/m0/s1 Key: SLJZVZKQYSKYNV-ZWKOTPCHSA-N
SMILES C1=CC(=CC=C1C[C@@H]([C@@H](C2=CC=C(C=C2)C#N)N3C=NC=N3)O)F
Pharmacology
ATCvet code	QG03XX90 ( WHO )
Legal status	EU:Rx-only [1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Finrozole is an aromatase (CYP19A1) inhibitor. ^[2]

Finrozole was authorized for veterinary use in the European Union in April 2025. ^[1]

Medical uses

Finrozole is indicated to shorten the pro-oestrus and oestrus period, reduce clinical signs of heat and reduce the risk of pregnancy. ^[1]

References

1. "Prevestrus vet PI". Union Register of medicinal products. 25 April 2025. Retrieved 3 May 2025.
2. Huuskonen, P; Myllynen, P; Storvik, M; Pasanen, M (2013). "The effects of aflatoxin B1 on transporters and steroid metabolizing enzymes in JEG-3 cells". Toxicology Letters. 218 (3): 200–6. doi:10.1016/j.toxlet.2013.01.015. PMID   23402939.