Receptor protein serine/threonine kinase

Receptor protein serine/threonine kinase
Identifiers
Symbol	Receptor protein serine/threonine kinase
Membranome	1031

Receptor protein serine/threonine kinase
Identifiers
EC no.	2.7.11.30
CAS no.	146702-86-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Receptor protein serine/threonine kinases (EC 2.7.11.30) are enzyme-linked receptors that belong to protein-serine/threonine kinases. The systematic name of this enzyme class is ATP:[receptor-protein] phosphotransferase. Proteins from this group participate in 7 metabolic pathways: MAPK signaling pathway, cytokine-cytokine receptor interaction, TGF beta signaling pathway, adherens junction, colorectal cancer, pancreatic cancer, and chronic myeloid leukemia.

Receptor serine/threonine kinases directly phosphorylate specific serines or threonines on themselves and latent gene regulatory proteins associated with them.

Links

• Receptor protein serine/threonine kinases in IUPHAR Guide to Pharmacology

References

• Wrana JL, Attisano L, Wieser R, Ventura F, Massague J (1994). "Mechanism of activation of the TGF-beta receptor". Nature. 370 (6488): 341–7. Bibcode:1994Natur.370..341W. doi:10.1038/370341a0. PMID   8047140. S2CID   4344481.
• Massague J, Chen YG (2000). "Controlling TGF-beta signaling". Genes Dev. 14 (6): 627–44. doi: 10.1101/gad.14.6.627 . PMID   10733523.
• Lechleider RJ; Hemmati, P; Larisch-Bloch, S; Ajmera, R; Roberts, AB; Lechleider, RJ (1997). "Characterization of functional domains within Smad4/DPC4". J. Biol. Chem. 272 (21): 13690–6. doi: 10.1074/jbc.272.21.13690 . PMID   9153220.