Myosin-2

Last updated
MYH2
Identifiers
Aliases MYH2 , IBM3, MYH2A, MYHSA2, MYHas8, MyHC-2A, MyHC-IIa, MYPOP, myosin, heavy chain 2, skeletal muscle, adult, myosin heavy chain 2
External IDs OMIM: 160740 MGI: 1339710 HomoloGene: 23019 GeneCards: MYH2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_017534
NM_001100112

NM_001039545
NM_144961

RefSeq (protein)

NP_001093582
NP_060004

NP_001034634

Location (UCSC) Chr 17: 10.52 – 10.55 Mb Chr 11: 67.06 – 67.09 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myosin-2 (myosin heavy chain 2) is a protein that in humans is encoded by the MYH2 gene. [5] [6]

Related Research Articles

<span class="mw-page-title-main">MYH16 gene</span> Pseudogene in the species Homo sapiens

The MYH16 gene encodes a protein called myosin heavy chain 16, which is a muscle protein in mammals. At least in primates, it is a specialized muscle protein found only in the temporalis and masseter muscles of the jaw. Myosin heavy chain proteins are important in muscle contraction, and if they are missing, the muscles will be smaller. In non-human primates, MYH16 is functional and the animals have powerful jaw muscles. In humans, the MYH16 gene has a mutation that causes the protein not to function. Although the exact importance of this change in accounting for differences between humans and other apes is not yet clear, such a change may be related to increased brain size and finer control of the jaw, which facilitates speech. It is not clear how the MYH16 mutation relates to other changes to the jaw and skull in early human evolution.

<span class="mw-page-title-main">MYH7</span>

MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform expressed primarily in the heart, but also in skeletal muscles. This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick filament in cardiac muscle and plays a major role in cardiac muscle contraction.

<span class="mw-page-title-main">TPM1</span>

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.

<span class="mw-page-title-main">MYH9</span>

Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in humans is encoded by the MYH9 gene.

<span class="mw-page-title-main">MYH10</span> Protein-coding gene in the species Homo sapiens

Myosin-10 also known as myosin heavy chain 10 or non-muscle myosin IIB (NM-IIB) is a protein that in humans is encoded by the MYH10 gene. Non-muscle myosins are expressed in a wide variety of tissues, but NM-IIB is the only non-muscle myosin II isoform expressed in cardiac muscle, where it localizes to adherens junctions within intercalated discs. NM-IIB is essential for normal development of cardiac muscle and for integrity of intercalated discs. Mutations in MYH10 have been identified in patients with left atrial enlargement.

<span class="mw-page-title-main">Myosin-11</span>

Myosin-11 is a protein that in humans is encoded by the MYH11 gene.

<span class="mw-page-title-main">MYH6</span>

Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human cardiac ventricles. It is the major protein comprising the cardiac muscle thick filament, and functions in cardiac muscle contraction. Mutations in MYH6 have been associated with late-onset hypertrophic cardiomyopathy, atrial septal defects and sick sinus syndrome.

<span class="mw-page-title-main">MYL3</span> Protein-coding gene in the species Homo sapiens

Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule and is important in modulating cardiac muscle contraction.

<span class="mw-page-title-main">MYH1</span> Protein-coding gene in the species Homo sapiens

Myosin-1, also known as 'striated muscle myosin heavy chain 1', is a protein that in humans is encoded by the MYH1 gene. This gene is most highly expressed in fast type IIX/D muscle fibres of vertebrates and encodes a protein found uniquely in striated muscle; it is a class II myosin with a long coiled coil tail that dimerizes and should not be confused with 'Myosin 1' encoded by the MYO1 family of genes (MYO1A-MYO1H). Class I MYO1 genes function in many cell types throughout biology and are single-headed membrane-binding myosins that lack a long coiled coil tail.

<span class="mw-page-title-main">MYH14</span> Protein-coding gene in the species Homo sapiens

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.

<span class="mw-page-title-main">TRIM63</span>

E3 ubiquitin-protein ligase TRIM63, also known as "MuRF1", is an enzyme that in humans is encoded by the TRIM63 gene.

<span class="mw-page-title-main">MYL1</span>

Myosin light chain 3, skeletal muscle isoform is a protein that in humans is encoded by the MYL1 gene.

<span class="mw-page-title-main">MYH3</span> Protein-coding gene in the species Homo sapiens

Myosin-3 is a protein that in humans is encoded by the MYH3 gene.

<span class="mw-page-title-main">MYH8</span> Protein-coding gene in the species Homo sapiens

Myosin-8 is a protein that in humans is encoded by the MYH8 gene.

<span class="mw-page-title-main">MYL6B</span>

Myosin light chain 6B is a protein that in humans is encoded by the MYL6B gene. Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue.

<span class="mw-page-title-main">MYLK2</span> Protein-coding gene in the species Homo sapiens

Myosin light chain kinase 2 also known as MYLK2 is an enzyme which in humans is encoded by the MYLK2 gene.

<span class="mw-page-title-main">MYH15</span>

Myosin-15 also known as myosin, heavy chain 15 is a protein that in humans is encoded by the MYH15 gene.

<span class="mw-page-title-main">MYH13</span> Protein-coding gene in the species Homo sapiens

Myosin-13 also known as myosin, heavy chain 13 is a protein which in humans is encoded by the MYH13 gene.

<span class="mw-page-title-main">MYH7B</span> Protein-coding gene in the species Homo sapiens

Myosin-7B also known as myosin, heavy chain 7B is a protein that in humans is encoded by the MYH7B gene.

<span class="mw-page-title-main">MYH4</span> Protein-coding gene in the species Homo sapiens

Myosin-4 also known as myosin, heavy chain 4 is a protein which in humans is encoded by the MYH4 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000125414 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033196 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. doi:10.1152/ajpcell.1994.267.6.C1723. PMID   7545970.
  6. "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

Further reading