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The historical application of biotechnology throughout time is provided below in chronological order.
These discoveries, inventions and modifications are evidence of the application of biotechnology since before the common era and describe notable events in the research, development and regulation of biotechnology.
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Some of these items may also have potential nonmedical applications and vice versa.
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: CS1 maint: numeric names: authors list (link)Compared to non-immunized guinea pigs, vaccinated animals exposed to infected ticks quickly developed redness at the tick bite site. None of the immunized animals developed Lyme disease if ticks were removed when redness developed. In contrast, about half of the control group became infected with B. burgdorferi after tick removal. When a single infected tick was attached to immunized guinea pigs and not removed, none of vaccinated animals were infected compared to 60 percent of control animals. However, protection waned in immunized guinea pigs if three ticks remained attached to the animal. Ticks in immunized animals were unable to feed aggressively and dislodged more quickly than those on guinea pigs in the control group.
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