Tropomodulin 2

Last updated
TMOD2
Identifiers
Aliases TMOD2 , N-TMOD, NTMOD, tropomodulin 2
External IDs OMIM: 602928 MGI: 1355335 HomoloGene: 22817 GeneCards: TMOD2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014548
NM_001142885

NM_001038710
NM_016711

RefSeq (protein)

NP_001136357
NP_055363

NP_001033799
NP_057920

Location (UCSC) Chr 15: 51.75 – 51.82 Mb Chr 9: 75.57 – 75.61 Mb
PubMed search [3] [4]
Wikidata
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Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene. [5]

Contents

Function

This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is dependent on its association with tropomyosin. Alternatively spliced transcript variants encoding different isoforms have been described. [6]

Related Research Articles

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RNF13

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Tropomodulin 3

Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.

EPS8L1

Epidermal growth factor receptor kinase substrate 8-like protein 1 is an enzyme that in humans is encoded by the EPS8L1 gene.

EPS8L3

Epidermal growth factor receptor kinase substrate 8-like protein 3 is an enzyme that in humans is encoded by the EPS8L3 gene.

TDRD3

Tudor domain-containing protein 3 is a protein that in humans is encoded by the TDRD3 gene. It contains a Tudor domain and UBA protein domain and has three distinct Protein isoforms.

DUSP15

Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15 gene.

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Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.

Tropomodulin 4

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000128872 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032186 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Cox PR, Zoghbi HY (January 2000). "Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs". Genomics. 63 (1): 97–107. doi:10.1006/geno.1999.6061. PMID   10662549.
  6. "Entrez Gene: TMOD2, Tropomodulin 2 (neuronal)".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.