Tropomodulin 1

TMOD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4PKG, 4PKH, 4PKI, 4Z8G, 4Z94
Identifiers
Aliases	TMOD1 , D9S57E, ETMOD, TMOD, tropomodulin 1
External IDs	OMIM: 190930 MGI: 98775 HomoloGene: 20701 GeneCards: TMOD1
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	46,116,032 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; gastric mucosa; ; spinal ganglia; ; left ventricle; ; skeletal muscle tissue; ; body of tongue; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; deltoid muscle; ; trigeminal ganglion;
	Top expressed in
	quadriceps femoris muscle; ; right ventricle; ; myocardium of ventricle; ; gastrocnemius muscle; ; temporal muscle; ; utricle; ; skeletal muscle tissue; ; sternocleidomastoid muscle; ; extraocular muscle; ; tibialis anterior muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	actin filament binding ; actin binding ; tropomyosin binding ;
Cellular component	membrane ; COP9 signalosome ; cytoskeleton ; cytosol ; cortical cytoskeleton ; cytoplasm ; sarcomere ; myofibril ; actin filament ; striated muscle thin filament ;
Biological process	adult locomotory behavior ; lens fiber cell development ; muscle filament sliding ; pointed-end actin filament capping ; muscle contraction ; actin filament organization ; myofibril assembly ;
	Sources:Amigo / QuickGO
Orthologs
	7111
	21916
	n/a
	ENSMUSG00000028328
	P28289
	P49813
	NM_003275 ; NM_001166116
	NM_021883
	NP_001159588 ; NP_003266
	NP_068683
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 15, 2023

Tropomodulin-1 is a protein that in humans is encoded by the TMOD1 gene.^[4]^[5]^[6]

Related Research Articles

Tropomyosin is a two-stranded alpha-helical, coiled coil protein found in many animal and fungal cells. In animals, it is an important component of the muscular system which works in conjunction with troponin to regulate muscle contraction. It is present in smooth and striated muscle tissues, which can be found in various organs and body systems, including the heart, blood vessels, respiratory system, and digestive system. In fungi, tropomyosin is found in cell walls and helps maintain the structural integrity of cells.

Caldesmon is a protein that in humans is encoded by the CALD1 gene.

Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene.

Bradykinin receptor B₂ is a G-protein coupled receptor for bradykinin, encoded by the BDKRB2 gene in humans.

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.

Tropomyosin alpha-3 chain is a protein that in humans is encoded by the TPM3 gene.

Sulfotransferase 1A3/1A4 is an enzyme that in humans is encoded by the SULT1A3 gene.

Drebrin is a protein that in humans is encoded by the DBN1 gene.

Plasma membrane calcium-transporting ATPase 2 is an enzyme that in humans is encoded by the ATP2B2 gene.

Beta-adducin is a protein that in humans is encoded by the ADD2 gene.

Protein-L-isoaspartate(D-aspartate) O-methyltransferase is an enzyme that in humans is encoded by the PCMT1 gene.

Thymosin beta-10 is a protein that in humans is encoded by the TMSB10 gene. TMSB10 is a member of the beta-thymosin family of peptides.

Gamma-adducin is a protein that in humans is encoded by the ADD3 gene.

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.

Troponin C, skeletal muscle is a protein that in humans is encoded by the TNNC2 gene.

Ankyrin 1, also known as ANK-1, and erythrocyte ankyrin, is a protein that in humans is encoded by the ANK1 gene.

Tropomodulin-3 is a protein that in humans is encoded by the TMOD3 gene.

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.

Tropomodulin 2 (neuronal) also known as TMOD2 is a protein which in humans is encoded by the TMOD2 gene.

Cofilin 2 (muscle) also known as CFL2 is a protein which in humans is encoded by the CFL2 gene.

References

1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028328 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S (Mar 1992). "Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein". J Biol Chem. 267 (4): 2616–21. doi: 10.1016/S0021-9258(18)45926-1 . PMID 1370827.
↑ Sung LA, Fan Y, Lin CC (Dec 1996). "Gene assignment, expression, and homology of human tropomodulin". Genomics. 34 (1): 92–6. doi:10.1006/geno.1996.0245. PMID 8661028.
↑ "Entrez Gene: TMOD1 tropomodulin 1".

Ursitti JA, Fowler VM (1994). "Immunolocalization of tropomodulin, tropomyosin and actin in spread human erythrocyte skeletons". J. Cell Sci. 107 (6): 1633–9. doi:10.1242/jcs.107.6.1633. PMID 7962203.
Sung LA, Lin JJ (1994). "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma-tropomyosin gene". Biochem. Biophys. Res. Commun. 201 (2): 627–34. doi:10.1006/bbrc.1994.1747. PMID 8002995.
Sussman MA, Bilak M, Kedes L, et al. (1994). "Tropomodulin is highly concentrated at the postsynaptic domain of human and rat neuromuscular junctions". Exp. Cell Res. 209 (2): 388–91. doi:10.1006/excr.1993.1325. PMID 8262158.
Lench NJ, Telford EA, Andersen SE, et al. (1997). "An EST and STS-based YAC contig map of human chromosome 9q22.3". Genomics. 38 (2): 199–205. doi:10.1006/geno.1996.0616. PMID 8954802.
Vera C, Sood A, Gao KM, et al. (2000). "Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5". Arch. Biochem. Biophys. 378 (1): 16–24. doi:10.1006/abbi.2000.1802. PMID 10871039.
McElhinny AS, Kolmerer B, Fowler VM, et al. (2001). "The N-terminal end of nebulin interacts with tropomodulin at the pointed ends of the thin filaments". J. Biol. Chem. 276 (1): 583–92. doi: 10.1074/jbc.M005693200 . PMID 11016930.
Chu X, Thompson D, Yee LJ, Sung LA (2001). "Genomic organization of mouse and human erythrocyte tropomodulin genes encoding the pointed end capping protein for the actin filaments". Gene. 256 (1–2): 271–81. doi:10.1016/S0378-1119(00)00327-9. PMID 11054557.
Greenfield NJ, Fowler VM (2002). "Tropomyosin requires an intact N-terminal coiled coil to interact with tropomodulin". Biophys. J. 82 (5): 2580–91. Bibcode:2002BpJ....82.2580G. doi:10.1016/S0006-3495(02)75600-2. PMC 1302047 . PMID 11964245.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Rho SB, Chun T, Lee SH, et al. (2004). "The interaction between E-tropomodulin and thymosin beta-10 rescues tumor cells from thymosin beta-10 mediated apoptosis by restoring actin architecture". FEBS Lett. 557 (1–3): 57–63. doi: 10.1016/S0014-5793(03)01438-8 . PMID 14741341. S2CID 84342157.
Pawlak G, McGarvey TW, Nguyen TB, et al. (2004). "Alterations in tropomyosin isoform expression in human transitional cell carcinoma of the urinary bladder". Int. J. Cancer. 110 (3): 368–73. doi:10.1002/ijc.20151. PMID 15095301. S2CID 875146.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC 2734081 . PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: further insights into E-Tmod/TM5 interaction". Arch. Biochem. Biophys. 444 (2): 130–8. doi:10.1016/j.abb.2005.10.002. PMID 16297372.
Kong KY, Kedes L (2006). "Leucine 135 of tropomodulin-1 regulates its association with tropomyosin, its cellular localization, and the integrity of sarcomeres". J. Biol. Chem. 281 (14): 9589–99. doi: 10.1074/jbc.M512064200 . PMID 16434395.

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[refGRCm38Ensembl-1] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028328 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1370827-4] Sung LA, Fowler VM, Lambert K, Sussman MA, Karr D, Chien S (Mar 1992). "Molecular cloning and characterization of human fetal liver tropomodulin. A tropomyosin-binding protein". J Biol Chem. 267 (4): 2616–21. doi: 10.1016/S0021-9258(18)45926-1 . PMID 1370827.

[pmid8661028-5] Sung LA, Fan Y, Lin CC (Dec 1996). "Gene assignment, expression, and homology of human tropomodulin". Genomics. 34 (1): 92–6. doi:10.1006/geno.1996.0245. PMID 8661028.

[entrez-6] "Entrez Gene: TMOD1 tropomodulin 1".

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Tropomodulin 1

Related Research Articles

References

Further reading