Unconventional myosin-Ia

MYO1A
Identifiers
Aliases	MYO1A , BBMI, DFNA48, MIHC, MYHL, myosin IA
External IDs	OMIM: 601478 MGI: 107732 HomoloGene: 21113 GeneCards: MYO1A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	57,051,198 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	127,556,809 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; duodenum; ; body of stomach; ; gallbladder; ; appendix; ; gastric mucosa; ; fundus; ; monocyte; ; smooth muscle tissue;
	Top expressed in
	jejunum; ; duodenum; ; colon; ; ileum; ; left colon; ; Epithelium of stomach; ; Paneth cell; ; spermatocyte; ; spermatid; ; seminiferous tubule;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding ; actin binding ; actin filament binding ; cytoskeletal motor activity ; calmodulin binding ; ATP binding ; microtubule motor activity ; microtubule binding ;
Cellular component	filamentous actin ; brush border ; cytoplasm ; cortical actin cytoskeleton ; microvillus ; apical plasma membrane ; basal plasma membrane ; plasma membrane raft ; myosin complex ; basolateral plasma membrane ; lateral plasma membrane ;
Biological process	sensory perception of sound ; microvillus assembly ; cell projection organization ; vesicle localization ; microtubule-based movement ;
	Sources:Amigo / QuickGO
Orthologs
	4640
	432516
	ENSG00000166866
	ENSMUSG00000025401
	Q9UBC5
	O88329
	NM_001256041 ; NM_005379
	NM_001081219
	NP_001242970 ; NP_005370
	NP_001074688
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 29, 2023

Unconventional myosin-Ia is a protein that in humans is encoded by the MYO1A gene.^[5]^[6]^[7]

The protein encoded by this gene belongs to the myosin superfamily. Myosins are molecular motors that, upon interaction with actin filaments, utilize energy from ATP hydrolysis to generate mechanical force. Each myosin has a conserved N-terminal motor domain that contains both ATP-binding and actin-binding sequences. Following the motor domain is a light-chain-binding 'neck' region containing 1-6 copies of a repeat element, the IQ motif, that serves as a binding site for calmodulin or other members of the EF-hand superfamily of calcium-binding proteins. At the C-terminus, each myosin class has a distinct tail domain that serves in dimerization, membrane binding, protein binding, and/or enzymatic activities and targets each myosin to its particular subcellular location. The myosin-Ia protein is expressed by enterocytes, the epithelial cells that line the luminal surface of the small intestine. In these cells the myosin-1a protein localizes specifically to the brush border. Experiments indicate that the brush border population of the encoded protein turns over rapidly, while its head and tail domains interact transiently with the core actin and plasma membrane, respectively. A rapidly exchanging pool of the unconventional myosin-Ia protein binds to the actin core bundle, which turns over on a much slower timescale.^[8]

Related Research Articles

<span class="mw-page-title-main">Myosin</span> Superfamily of motor proteins

Myosins are a superfamily of motor proteins best known for their roles in muscle contraction and in a wide range of other motility processes in eukaryotes. They are ATP-dependent and responsible for actin-based motility.

Myosin VIIA is protein that in humans is encoded by the MYO7A gene. Myosin VIIA is a member of the unconventional myosin superfamily of proteins. Myosins are actin binding molecular motors that use the enzymatic conversion of ATP - ADP + inorganic phosphate (Pi) to provide the energy for movement.

Melanophilin is a carrier protein which in humans is encoded by the MLPH gene. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Unconventional myosin-Va is a motor protein in charge of the intracellular transport of vesicles, organelles and protein complexes along the actin filaments. In humans it is coded for by the MYO5A gene.

Tropomyosin alpha-1 chain is a protein that in humans is encoded by the TPM1 gene. This gene is a member of the tropomyosin (Tm) family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells.

Unconventional myosin-VI, is a protein that in humans is coded for by MYO6. Unconventional myosin-VI is a myosin molecular motor involved in intracellular vesicle and organelle transport.

WAS/WASL-interacting protein (WIP) is a protein that in humans is encoded by the WIPF1 gene.

MYO9B is a gene that encodes the Myosin-IXb protein.

Myosin-Ic is a protein that in humans is encoded by the MYO1C gene.

Myosin X, also known as MYO10, is a protein that in humans is encoded by the MYO10 gene.

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.

Myosin-XVIIIa is a protein that in humans is encoded by the MYO18A gene.

Myosin-Vb, a myosin V type protein, is encoded by the MYO5B gene in humans.

Myosin-IIIa is a protein that in humans is encoded by the MYO3A gene.

Myosin-Ib is a protein that in humans is encoded by the MYO1B gene.

Myosin-If is a protein that in humans is encoded by the MYO1F gene.

Myosin-XVIIIb is a protein that in humans is encoded by the MYO18B gene.

Myosin-Ie (Myo1e) is a protein that in humans is encoded by the MYO1E gene.

Myosin-XV is a protein that in humans is encoded by the MYO15A gene.

Espin, also known as autosomal recessive deafness type 36 protein or ectoplasmic specialization protein, is a protein that in humans is encoded by the ESPN gene. Espin is a microfilament binding protein.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166866 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025401 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi: 10.1006/geno.1996.0488 . PMID 8884266.
↑ Donaudy F, Ferrara A, Esposito L, Hertzano R, Ben-David O, Bell RE, Melchionda S, Zelante L, Avraham KB, Gasparini P (May 2003). "Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss". Am J Hum Genet. 72 (6): 1571–7. doi:10.1086/375654. PMC 1180318 . PMID 12736868.
↑ "MYO1A - Unconventional myosin-Ia - Homo sapiens (Human) - MYO1A gene & protein". www.uniprot.org. Retrieved 7 April 2022.
↑ Tyska MJ, Mooseker MS (April 2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells". Biophys. J. 82 (4): 1869–83. Bibcode:2002BpJ....82.1869T. doi:10.1016/S0006-3495(02)75537-9. PMC 1301984 . PMID 11916846. Archived from the original on 2007-12-27.

Hofmann WA, Johnson T, Klapczynski M, et al. (2007). "From transcription to transport: emerging roles for nuclear myosin I.". Biochem. Cell Biol. 84 (4): 418–26. doi:10.1139/o06-069. PMID 16936815.
Hoshimaru M, Fujio Y, Sobue K, et al. (1990). "Immunochemical evidence that myosin I heavy chain-like protein is identical to the 110-kilodalton brush-border protein". J. Biochem. 106 (3): 455–9. doi:10.1093/oxfordjournals.jbchem.a122873. PMID 2606897.
Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi: 10.1073/pnas.91.14.6549 . PMC 44240 . PMID 8022818.
Durrbach A, Collins K, Matsudaira P, et al. (1996). "Brush border myosin-I truncated in the motor domain impairs the distribution and the function of endocytic compartments in an hepatoma cell line". Proc. Natl. Acad. Sci. U.S.A. 93 (14): 7053–8. Bibcode:1996PNAS...93.7053D. doi: 10.1073/pnas.93.14.7053 . PMC 38934 . PMID 8692943.
Skowron JF, Bement WM, Mooseker MS (1999). "Human brush border myosin-I and myosin-Ic expression in human intestine and Caco-2BBe cells". Cell Motil. Cytoskeleton. 41 (4): 308–24. doi:10.1002/(SICI)1097-0169(1998)41:4<308::AID-CM4>3.0.CO;2-J. PMID 9858156.
Li W, Wang J, Coluccio LM, et al. (2000). "Brush border myosin I (BBMI): a basally localized transcript in human jejunal enterocytes". J. Histochem. Cytochem. 48 (1): 89–94. doi: 10.1177/002215540004800109 . PMID 10653589.
Otterbein LR, Graceffa P, Dominguez R (2001). "The crystal structure of uncomplexed actin in the ADP state". Science. 293 (5530): 708–11. doi:10.1126/science.1059700. PMID 11474115. S2CID 12030018.
Tyska MJ, Mooseker MS (2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells". Biophys. J. 82 (4): 1869–83. Bibcode:2002BpJ....82.1869T. doi:10.1016/S0006-3495(02)75537-9. PMC 1301984 . PMID 11916846.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
D'Adamo P, Pinna M, Capobianco S, et al. (2003). "A novel autosomal dominant non-syndromic deafness locus (DFNA48) maps to 12q13-q14 in a large Italian family". Hum. Genet. 112 (3): 319–20. doi:10.1007/s00439-002-0880-6. PMID 12596055. S2CID 28077750.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166866 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025401 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884266-5] Hasson T, Skowron JF, Gilbert DJ, Avraham KB, Perry WL, Bement WM, Anderson BL, Sherr EH, Chen ZY, Greene LA, Ward DC, Corey DP, Mooseker MS, Copeland NG, Jenkins NA (Feb 1997). "Mapping of unconventional myosins in mouse and human". Genomics. 36 (3): 431–9. doi: 10.1006/geno.1996.0488 . PMID 8884266.

[pmid12736868-6] Donaudy F, Ferrara A, Esposito L, Hertzano R, Ben-David O, Bell RE, Melchionda S, Zelante L, Avraham KB, Gasparini P (May 2003). "Multiple mutations of MYO1A, a cochlear-expressed gene, in sensorineural hearing loss". Am J Hum Genet. 72 (6): 1571–7. doi:10.1086/375654. PMC 1180318 . PMID 12736868.

[uniprot-7] "MYO1A - Unconventional myosin-Ia - Homo sapiens (Human) - MYO1A gene & protein". www.uniprot.org. Retrieved 7 April 2022.

[pmid11916846-8] Tyska MJ, Mooseker MS (April 2002). "MYO1A (brush border myosin I) dynamics in the brush border of LLC-PK1-CL4 cells". Biophys. J. 82 (4): 1869–83. Bibcode:2002BpJ....82.1869T. doi:10.1016/S0006-3495(02)75537-9. PMC 1301984 . PMID 11916846. Archived from the original on 2007-12-27.

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Unconventional myosin-Ia

Related Research Articles

References

Further reading