California Proposition 65 list of chemicals

Last updated

The following is a list of chemicals published as a requirement of Safe Drinking Water and Toxic Enforcement Act of 1986, commonly known as California Proposition 65, that are "known to the state to cause cancer or reproductive toxicity" as of January 3, 2020. [1] As a result of lawsuits, the list also contains substances known only to cause cancer in animals. [2]

Contents

This list is not exhaustive, as the complete list contains over 900 chemicals. [2]

Chemicals currently listed under California Proposition 65

Current Proposition 65 list
SubstanceReason CAS Registry NumberDate Listed
A-alpha-C (2-Amino-9H-pyrido[2,3-b]indole)Cancer26148-68-5January 1, 1990
1,4-Dichloro-2-nitrobenzene Cancer89-61-2September 13, 2019
p-chloro-α,α,α-trifluorotoluene (para-Chlorobenzotrifluoride, PCBTF) Cancer98-56-6June 28, 2019
Bevacizumab Developmental

Reproductive toxicity (female, male)

216974-75-3March 8, 2019
Aflatoxins Cancer---January 1, 1988
Ceramic fibers (airborne particles of respirable size)Cancer---February 27, 1987
Certain combined chemotherapy for lymphomas Cancer---February 27, 1987
para-Nitroanisole Cancer100-17-4September 13, 2019
2,4-Dichloro-1-nitrobenzene Cancer611-06-3September 13, 2019
Δ9-Tetrahydrocannabinol (Δ9-THC) DevelopmentalJanuary 3, 2020
2-Chloronitrobenzene Cancer88-73-3September 13, 2019
2-Amino-4-chlorophenol Cancer95-85-2September 13, 2019
Cannabis (marijuana) smokeDevelopmental---January 3, 2020
Abiraterone acetate Developmental

Reproductive toxicity (female, male)

154229-18-2April 8, 2016
Acetaldehyde Cancer75-07-0April 1, 1988
Acetamide Cancer60-35-5January 1, 1990
Acetazolamide Developmental59-66-5August 20, 1999
Acetochlor Cancer34256-82-1January 1, 1989
Acetohydroxamic acid Developmental546-88-3April 1, 1990
2-Acetylaminofluorene Cancer53-96-3July 1, 1987
Acifluorfen sodiumCancer62476-59-9January 1, 1990
Acrylamide Cancer

Developmental Reproductive toxicity (male)

79-06-1January 1, 1990

February 25, 2011

Acrylonitrile Cancer107-13-1July 1, 1987
Actinomycin D Cancer

Developmental

50-76-0October 1, 1989

October 1, 1992

AF-2 ([2-(2-furyl)-3-(5-nitro-2-furyl)]acrylamide)Cancer3688-53-7July 1, 1987
Alachlor Cancer15972-60-8January 1, 1989
Alcoholic beverages

Alcoholic beverages, when associated with alcohol abuse

Cancer---April 29, 2011

July 1, 1988

Aldrin Cancer309-00-2July 1, 1988
All-trans retinoic acid Developmental302-79-4January 1, 1989
Aloe vera, non-decolorized whole leaf extractCancerDecember 4, 2015
Alprazolam Developmental28981-97-7July 1, 1990
Altretamine Developmental

Reproductive toxicity (male)

645-05-6August 20, 1999
Amantadine hydrochloride Developmental665-66-7February 27, 2001
Amikacin sulfate Developmental39831-55-5July 1, 1990
2-Aminoanthraquinone Cancer117-79-3October 1, 1989
p-Aminoazobenzene Cancer60-09-3January 1, 1990
o-Aminoazotoluene Cancer97-56-3July 1, 1987
4-Aminobiphenyl (4-amino-diphenyl)Cancer92-67-1February 27, 1987
1-Amino-2,4-dibromoanthraquinone Cancer81-49-2August 26, 1997
3-Amino-9-ethylcarbazole hydrochloride Cancer6109-97-3July 1, 1989
2-Aminofluorene Cancer153-78-6January 29, 1999
Aminoglutethimide Developmental125-84-8July 1, 1990
Aminoglycosides DevelopmentalOctober 1, 1992
1-Amino-2-methylanthraquinone (Disperse Orange 11)Cancer82-28-0October 1, 1989
2-Amino-5-(5-nitro-2-furyl)-1,3,4-thiadiazole Cancer712-68-5July 1, 1987
4-Amino-2-nitrophenol Cancer119-34-6January 29, 1999
Aminopterin Developmental

Reproductive toxicity (female)

54-62-6July 1, 1987
Amiodarone hydrochloride Developmental

Reproductive toxicity (female, male)

19774-82-4August 26, 1997
Amitraz Developmental33089-61-1March 30, 1999
Amitrole Cancer61-82-5July 1, 1987
Amoxapine Developmental14028-44-5May 15, 1998
Amsacrine Cancer51264-14-3August 7, 2009
Anabolic steroids Reproductive toxicity (female, male)April 1, 1990
Androstenedione Cancer63-05-8May 3, 2011
ACE inhibitors (Angiotensin converting enzyme)DevelopmentalOctober 1, 1992
Aniline Cancer62-53-3January 1, 1990
Aniline hydrochloride Cancer142-04-1May 15, 1998
o-Anisidine Cancer90-04-0July 1, 1987
o-Anisidine hydrochloride Cancer134-29-2July 1, 1987
Anisindione Developmental117-37-3October 1, 1992
Anthracene Cancer120-12-7August 11, 2023
Anthraquinone Cancer84-65-1September 28, 2007
Antimony oxide (Antimony trioxide)Cancer1309-64-4October 1, 1990
Aramite Cancer140-57-8July 1, 1987
Areca nut CancerFebruary 3, 2006
Aristolochic acids CancerJuly 9, 2004
Arsenic (inorganic arsenic compounds)CancerFebruary 27, 1987
Arsenic (inorganic oxides)DevelopmentalMay 1, 1997
Asbestos Cancer1332-21-4February 27, 1987
Aspirin during the last three months of pregnancyDevelopmental

Reproductive toxicity (female)

50-78-2July 1, 1990
Atenolol Developmental29122-68-7August 26, 1997
Atrazine Developmental

Reproductive toxicity (female)

1912-24-9July 15, 2016
Auramine Cancer492-80-8July 1, 1987
Auranofin Developmental34031-32-8January 29, 1999
Avermectin B1 (Abamectin)Developmental71751-41-2December 3, 2010
Azacitidine Cancer320-67-2January 1, 1992
Azaserine Cancer115-02-6July 1, 1987
Azathioprine Cancer

Developmental

446-86-6February 27, 1987

September 1, 1996

Azobenzene Cancer103-33-3January 1, 1990
Barbiturates DevelopmentalOctober 1, 1992
Beclomethasone dipropionate Developmental5534-09-8May 15, 1998
Benomyl Developmental

Reproductive toxicity (male)

17804-35-2July 1, 1991
Benthiavalicarb-isopropyl Cancer177406-68-7July 1, 2008
Benz[a]anthracene Cancer56-55-3July 1, 1987
Benzene Cancer

Developmental Reproductive toxicity (male)

71-43-2February 27, 1987

December 26, 1997

Benzidine (and its salts)Cancer92-87-5February 27, 1987
Benzidine-based dyes CancerOctober 1, 1992
Benzodiazepines DevelopmentalOctober 1, 1992
Benzo[b]fluoranthene Cancer205-99-2July 1, 1987
Benzo[j]fluoranthene Cancer205-82-3July 1, 1987
Benzo[k]fluoranthene Cancer207-08-9July 1, 1987
Benzofuran Cancer271-89-6October 1, 1990
Benzophenone Cancer119-61-9
Benzo[a]pyrene Cancer50-32-8
Benzotrichloride Cancer98-07-7
Benzphetamine hydrochloride Developmental5411-22-3
Benzyl chloride Cancer100-44-7
Benzyl violet 4B Cancer1694-09-3July 1, 1987
Beryllium and beryllium compoundsCancer
Betel quid with tobaccoCancer
Betel quid without tobaccoCancer
2,2-Bis(bromomethyl)-1,3-propanediol Cancer3296-90-0
Bis(2-chloroethyl)ether Cancer111-44-4
N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornapazine)Cancer494-03-1
Bischloroethyl nitrosourea (BCNU, Carmustine)Developmental154-93-8July 1, 1987
Bis(chloromethyl)ether Cancer542-88-1
Bis(2-chloro-1-methylethyl)ether Cancer
Bisphenol A (BPA)Reproductive toxicity (female)

Developmental

80-05-7May 11, 2015

December 18, 2020

Bisphenol S Reproductive toxicity (female, male)80-09-1December 29, 2023

January 3, 2025

Bitumen, extracts of steam-refined and air refinedCancer
Bracken fern Cancer
Bromacil lithium salt Developmental,

Reproductive toxicity (male)

53404-19-6May 18, 1999

January 17, 2003

Bromate Cancer15541-45-4
Bromochloroacetic acid Cancer5589-96-8
Bromodichloroacetic acid Cancer71133-14-7
Bromodichloromethane Cancer75-27-4
Bromoethane Cancer74-96-4December 22, 2000
Bromoform Cancer75-25-2
1-Bromopropane (1-BP)Cancer

Developmental Reproductive toxicity (female, male)

106-94-5August 5, 2016

December 7, 2004

2-Bromopropane (2-BP)Cancer

Reproductive toxicity (female, male)

75-26-3August 11, 2023

May 31, 2005

1-Bromo-3-chloropropane Cancer109-70-6
Bromoxynil Developmental1689-84-5October 1, 1990
Bromoxynil octanoate Developmental1689-99-2
Butabarbital sodium Developmental143-81-7
1,3-Butadiene Cancer

Developmental Reproductive toxicity (female, male)

106-99-0April 1, 1988

April 16, 2004

1,4-Butanediol dimethanesulfonate (Busulfan)Cancer

Developmental

55-98-1February 27, 1987

January 1, 1989

1-Butyl glycidyl ether Cancer2426-08-6
Butylated hydroxyanisole Cancer25013-16-5
Butyl benzyl phthalate (BBP)Developmental85-68-7
beta-Butyrolactone Cancer3068-88-0July 1, 1987
Cacodylic acid Cancer75-60-5
Cadmium and cadmium compoundsDevelopmental

Reproductive toxicity (male) Cancer

May 1, 1997

October 1, 1987

Caffeic acid Cancer331-39-5
Captafol Cancer2425-06-1
Captan Cancer133-06-2
Carbamazepine Developmental298-46-4
Carbaryl Cancer

Developmental Reproductive toxicity (female, male)

63-25-2February 5, 2010

August 7, 2009

Carbazole Cancer86-74-8
Carbon black (airborne, unbound particles of respirable size)1333-86-4
Carbon-black extractsCancer---January 1, 1990
Carbon disulfide 75-15-0
Carbon monoxide 630-08-0
Carbon tetrachloride 56-23-5
Carboplatin 41575-94-4
N-Carboxymethyl-N-nitrosourea 60391-92-6
Catechol 120-80-9
Chenodiol 474-25-9
Chloral 75-87-6
Chloral hydrate 302-17-0
Chlorambucil 305-03-3
Chloramphenicol sodium succinate 982-57-0
Chlorcyclizine hydrochloride Developmental1620-21-9July 1, 1987
Chlordane 57-74-9
Chlordecone (Kepone)143-50-0
Chlordiazepoxide 58-25-3
Chlordiazepoxide hydrochloride 438-41-5
Chlordimeform 6164-98-3
Chlorendic acid 115-28-6
Chlorinated paraffins (Avg. chain length C12; approx. 60 percent chlorine by weight)108171-26-2
p-Chloroaniline 106-47-8
p-Chloroaniline hydrochloride 20265-96-7
Chloroethane 75-00-3
1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU, Lomustine)13010-47-4
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU)13909-09-6
Chloroform 67-66-3
Chloromethyl methyl ether 107-30-2
3-Chloro-2-methylpropene 563-47-3
1-Chloro-4-nitrobenzene 100-00-5
4-Chloro-o-phenylenediamine 95-83-0
Chloroprene 126-99-8
2-Chloropropionic acid 598-78-7
Chlorothalonil 1897-45-6
p-Chloro-o-toluidine 95-69-2
Strong acid salts of p-Chloro-o-toluidine
5-Chloro-o-toluidine and its strong acid salts95-79-4
Chlorotrianisene 569-57-3
Chlorozotocin 54749-90-5
Chlorpyrifos 2921-88-2
Chrysene 218-01-9
C.I. Acid Red 114 6459-94-5
C.I. Basic Red 9 monohydrochloride569-61-9
C.I. Direct Blue 15 2429-74-5
C.I. Direct Blue 218 28407-37-6
C.I. Disperse Yellow 3 2832-40-8
C.I. Solvent Yellow 14 842-07-9
Ciclosporin (Cyclosporine, Cyclosporine A)59865-13-3; 79217-60-0
Cidofovir 113852-37-2
Cinnamyl anthranilate 87-29-6
Cisplatin 15663-27-1
Citrus Red No. 2 6358-53-8
Cladribine 4291-63-8
Clarithromycin Developmental81103-11-9May 1, 1997
Clobetasol propionate 25122-46-7
Clofibrate 637-07-0
Clomiphene citrate 50-41-9
Clorazepate dipotassium 57109-90-7
CMNP (pyrazachlor)6814-58-0
Coal-tar pitch
Cobalt metal powder 7440-48-4
Cobalt(II) oxide 1307-96-6
Cobalt sulfate 10124-43-3
Cobalt sulfate heptahydrate 10026-24-1
Cocaine 50-36-2
Cocamide diethanolamine (Coconut oil diethanolamine condensate)
Codeine phosphate 52-28-8
Coke oven emissions
Colchicine 64-86-8
Conjugated estrogens
Creosotes
p-Cresidine 120-71-8
Cumene 98-82-8
Cupferron 135-20-6
Cyanazine 21725-46-2
Cycasin 14901-08-7
Cycloate 1134-23-2
Cycloheximide 66-81-9
Cyclopenta[cd]pyrene 27208-37-3
Cyclophosphamide 50-18-0; 6055-19-2
Cyhexatin 13121-70-5
Cytarabine 147-94-4
Cytembena 21739-91-3
D&C Orange No. 17 Cancer3468-63-1
D&C Red No. 8 Cancer2092-56-0October 1, 1990
D&C Red No. 9 Cancer5160-02-1
D&C Red No. 19 Cancer81-88-9
Dacarbazine 4342-03-4
Daminozide 1596-84-5
Danazol 17230-88-5
Dantron (Chrysazin; 1,8-Dihydroxyanthraquinone)117-10-2
Daunomycin 20830-81-3
Daunorubicin hydrochloride 23541-50-6
2,4-D butyric acid 94-82-6
DDD (Dichlorodiphenyl-dichloroethane)72-54-8
DDE (Dichlorodiphenyl-dichloroethylene)72-55-9
DDT (Dichlorodiphenyl-trichloroethane)50-29-3
o,p'-DDT 789-02-6
p,p'-DDT 50-29-3
DDVP (Dichlorvos)62-73-7
Demeclocycline hydrochloride 64-73-3
Des-ethyl atrazine (DEA)6190-65-4
Des-isopropyl atrazine (DIA)1007-28-9
N,N'-Diacetylbenzidine 613-35-4
2,4-Diaminoanisole Cancer615-05-4October 1, 1990
2,4-Diaminoanisole sulfate 39156-41-7
2,4-Diamino-6-chloro-s-triazine (DACT)3397-62-4
4,4'-Diaminodiphenyl ether (4,4'-Oxydianiline)101-80-4
2,4-Diaminotoluene 95-80-7
Diazepam 439-14-5
Diazoaminobenzene 136-35-6
Diazoxide 364-98-7
Dibenz[a,h]acridine 226-36-8
Dibenz[a,j]acridine 224-42-0
Dibenzanthracenes
Dibenz[a,c]anthracene 215-58-7
Dibenz[a,h]anthracene 53-70-3
Dibenz[a,j]anthracene 224-41-9
7H-Dibenzo[c,g]carbazole 194-59-2
Dibenzo[a,e]pyrene 192-65-4
Dibenzo[a,h]pyrene 189-64-0
Dibenzo[a,i]pyrene 189-55-9
Dibenzo[a,l]pyrene 191-30-0
Dibromoacetic acid 631-64-1
Dibromoacetonitrile 3252-43-5
1,2-Dibromo-3-chloropropane (DBCP)Cancer96-12-8July 1, 1987
2,3-Dibromo-1-propanol 96-13-9
Dichloroacetic acid 79-43-6
p-Dichlorobenzene 106-46-7
3,3'-Dichlorobenzidine 91-94-1
3,3'-Dichlorobenzidine dihydrochloride 612-83-9
1,4-Dichloro-2-butene 764-41-0
3,3'-Dichloro-4,4'-diamino-diphenyl ether 28434-86-8
1,1-Dichloroethane 75-34-3
Dichloromethane (Methylene chloride)75-09-2
Dichlorophene 97-23-4
Dichlorphenamide 120-97-8
1,2-Dichloropropane 78-87-5
1,3-Dichloro-2-propanol (1,3-DCP)96-23-1
1,3-Dichloropropene 542-75-6
Diclofop methyl 51338-27-3
Dicumarol 66-76-2
Dieldrin 60-57-1
Diepoxybutane 1464-53-5
Diesel engine exhaustCancerOctober 1, 1990
Diethanolamine 111-42-2
Di(2-ethylhexyl)phthalate (DEHP)117-81-7
1,2-Diethylhydrazine 1615-80-1
Diethylstilbestrol (DES)Cancer

Developmental

56-53-1February 27. 1987

July 1, 1987

Diethyl sulfate 64-67-5
Diflunisal 22494-42-4
Diglycidyl resorcinol ether (DGRE)101-90-6
Dihydroergotamine mesylate Develeopmental6190-39-2May 1, 1997
Dihydrosafrole 94-58-6
Di-isodecyl phthalate (DIDP)68515-49-1/ 26761-40-0
Diisononyl phthalate (DINP)
Diisopropyl sulfate 2973-10-6
Diltiazem hydrochloride 33286-22-5
3,3'-Dimethoxybenzidine (o-Dianisidine)119-90-4
3,3'-Dimethoxybenzidine dihydrochloride Cancer20325-40-0October 1, 1990
N,N-Dimethylacetamide 127-19-5
4-Dimethylaminoazobenzene 60-11-7
trans-2-[(Dimethylamino)methylimino]-5-[2-(5-nitro-2-furyl)vinyl]-1,3,4-oxadiazole55738-54-0
7,12-Dimethylbenz[a]anthracene 57-97-6
3,3'-Dimethylbenzidine (ortho-Tolidine)119-93-7
3,3'-Dimethylbenzidine dihydrochloride 612-82-8
Dimethylcarbamoyl chloride 79-44-7
1,1-Dimethylhydrazine (UDMH)57-14-7
1,2-Dimethylhydrazine 540-73-8
Dimethyl hydrogen phosphite 868-85-9
2,6-Dimethyl-N-nitrosomorpholine (DMNM)1456-28-6
Dimethyl sulfate 77-78-1
N,N-Dimethyl-p-toluidine 99-97-8
Dimethylvinylchloride 513-37-1
Di-n-butyl phthalate (DBP)84-74-2
Di-n-hexyl phthalate (DnHP)84-75-3
m-Dinitrobenzene 99-65-0
o-Dinitrobenzene 528-29-0
p-Dinitrobenzene 100-25-4
3,7-Dinitrofluoranthene 105735-71-5
3,9-Dinitrofluoranthene 22506-53-2
1,3-Dinitropyrene 75321-20-9
1,6-Dinitropyrene Cancer42397-64-8October 1, 1990
1,8-Dinitropyrene 42397-65-9
2,4-Dinitrotoluene 121-14-2
2,6-Dinitrotoluene 606-20-2
Dinitrotoluene
Dinocap 39300-45-3
Dinoseb 88-85-7
Di-n-propyl isocinchomeronate (MGK Repellent 326)136-45-8
1,4-Dioxane 123-91-1
Diphenylhydantoin (Phenytoin)Cancer

Developmental

57-41-0January 1, 1988

July 1, 1987

Diphenylhydantoin sodium salt Cancer630-93-3
Direct Black 38 1937-37-7
Direct Blue 6 2602-46-2
Direct Brown 95 16071-86-6
Disodium cyanodithioimidocarbonate 138-93-2
Disperse Blue 1 Cancer2475-45-8October 1, 1990
Diuron 330-54-1
Doxorubicin hydrochloride (Adriamycin)Cancer

Developmental Reproductive toxicity (male)

25316-40-9July 1, 1987

January 29, 1999

Doxycycline 564-25-0
Doxycycline calcium 94088-85-4
Doxycycline hyclate 24390-14-5
Doxycycline monohydrate 17086-28-1
Emissions from Combustion of coal
Emissions from high-temperature unrefined rapeseed oil
Endrin 72-20-8
Environmental tobacco smoke (ETS)
Epichlorohydrin 106-89-8
Epoxiconazole 135319-73-2
Ergotamine tartrate 379-79-3
Erionite 12510-42-8; 66733-21-9
Estradiol 50-28-2
Estragole 140-67-0
Estrogens (steroidal)
Estrone 53-16-7
Estropipate 7280-37-7
Ethanol in alcoholic beverages
Ethinylestradiol 57-63-6
Ethionamide 536-33-4
Ethoprop 13194-48-4
Ethyl acrylate 140-88-5
Ethylbenzene 100-41-4
Ethyl dipropylthiocarbamate 759-94-4
Ethyl-4,4'-dichlorobenzilate 510-15-6
Ethylene dibromide Cancer

Developmental Reproductive toxicity (male)

106-93-4July 1, 1987

May 15, 1998

Ethylene dichloride (1,2-Dichloroethane)107-06-2
Ethylene glycol (when ingested)107-21-1
Ethylene glycol monoethyl ether 110-80-5
Ethylene glycol monoethyl ether acetate 111-15-9
Ethylene glycol monomethyl ether 109-86-4
Ethylene glycol monomethyl ether acetate 110-49-6
Ethyleneimine (Aziridine)151-56-4
Ethylene oxide Cancer

Reproductive toxicity (female)

75-21-8July 1, 1987

February 27, 1987

Ethylene thiourea 96-45-7
Ethyl methanesulfonate 62-50-0
Etodolac 41340-25-4
Etoposide 33419-42-0
Etoposide in combination with Cisplatin and Bleomycin
Etretinate Developmental54350-48-0July 1, 1987
Fenoxaprop ethyl 66441-23-4
Fenoxycarb 72490-01-8
Filgrastim 121181-53-1
Fluazifop butyl 69806-50-4
Flunisolide 3385-03-3
Fluoro-edenite fibrous amphibole
Fluorouracil 51-21-8
Fluoxymesterone 76-43-7
Flurazepam hydrochloride 1172-18-5
Flurbiprofen 5104-49-4
Flutamide 13311-84-7
Fluticasone propionate 80474-14-2
Fluvalinate 69409-94-5
Folpet 133-07-3
Formaldehyde (gas)50-00-0
2-(2-Formylhydrazino)-4-(5-nitro-2-furyl)thiazole 3570-75-0
Fumonisin B1 116355-83-0
Furan 110-00-9
Furazolidone 67-45-8
Furfuryl alcohol 98-00-0
Furmecyclox 60568-05-0
Fusarin C 79748-81-5
Gallium arsenide 1303-00-0
Ganciclovir 82410-32-0
Ganciclovir sodium 107910-75-8
Gasoline engine exhaust (condensates/extracts)CancerOctober 1, 1990
Gemfibrozil Cancer

Reproductive toxicity (female, male)

25812-30-0December 22, 2000

August 20, 1999

Gentian violet(Crystal violet)548-62-9
Glass wool fibers (when inhalable and biopersistent)
Glu-P-1 (2-Amino-6-methyldipyrido[1,2- a:3',2'-d]imidazole)67730-11-4
Glu-P-2 (2-Aminodipyrido[1,2-a:3',2'-d]imidazole)67730-10-3
Glycidaldehyde 765-34-4
Glycidol 556-52-5
Glycidyl methacrylate 106-91-2
Glyphosate 1071-83-6
Goldenseal root powder
Goserelin acetate 65807-02-5
Griseofulvin 126-07-8
Gyromitrin (Acetaldehyde methylformylhydrazone)16568-02-8
Halazepam 23092-17-3
Halobetasol propionate 66852-54-8
Haloperidol 52-86-8
Halothane 151-67-7
HC Blue 1 2784-94-3
Heptachlor 76-44-8
Heptachlor epoxide 1024-57-3
Herbal remedies containing plant species of the genus Aristolochia
Hexachlorobenzene 118-74-1
Hexachlorobutadiene 87-68-3
Hexachlorocyclohexane
Hexachlorodibenzodioxin 34465-46- 8
Hexachloroethane 67-72-1
2,4-Hexadienal
Hexafluoroacetone 684-16-2
Hexamethylphosphoramide 680-31-9
n-Hexane 110-54-3
2,5-Hexanedione 110-13-4
Hexavalent chromium
Histrelin acetate
Hydramethylnon 67485-29-4
Hydrazine 302-01-2
Hydrazine sulfate 10034-93-2
Hydrazobenzene (1,2-Diphenylhydrazine)122-66-7
Hydrogen cyanide 74-90-8
1-Hydroxyanthraquinone Cancer129-43-1
Hydroxyurea Developmental127-07-1May 1, 1997
Idarubicin hydrochloride 57852-57-0
Ifosfamide 3778-73-2
Iodine-131 10043-66-0
Imazalil 35554-44-0
Indeno[1,2,3-cd]pyrene 193-39-5
Indium phosphide 22398-80-7
Indium tin oxide 50926-11-9
IQ (2-Amino-3-methylimidazo[4,5-f] quinoline)76180-96-6
Iprodione 36734-19-7
Iprovalicarb 140923-17-7; 140923-25-7
Iron dextran complex 9004-66-4
Isobutyl nitrite 542-56-3
Isoprene 78-79-5
Isopyrazam 881685-58-1
Isotretinoin Developmental4759-48-2July 1, 1987
Isoxaflutole Cancer141112-29-0December 22, 2000
Kresoxim-methyl 143390-89-0
Lactofen 77501-63-4
Lasiocarpine 303-34-4
Lead 7439-92-1
Lead and lead compounds Cancer
Lead acetate Cancer301-04-2
Lead phosphate Cancer7446-27-7
Lead subacetate Cancer1335-32-6
Leather dust Cancer
Leuprolide acetate 74381-53-6
Levodopa 59-92-7
Levonorgestrel implants797-63-7
Leucomalachite green Cancer129-73-7
Lindane and other hexachlorocyclohexane isomersCancer
Linuron Developmental330-55-2
Lithium carbonate Developmental554-13-2January 1, 1991
Lithium citrate Developmental919-16-4January 1, 1991
Lorazepam Developmental846-49-1
Lovastatin Developmental75330-75-5
Lynestrenol Cancer52-76-6
Malathion Cancer121-75-5
Malonaldehyde, sodium salt Cancer24382-04-5
Mancozeb Cancer8018-01-7
Maneb 12427-38-2
Me-A-alpha-C (2-Amino-3-methyl-9H-pyrido[2,3-b]indole)68006-83-7
Mebendazole 31431-39-7
Medroxyprogesterone acetate 71-58-9
Megestrol acetate Cancer

Developmental

595-33-5March 28, 2014

January 1, 1991

MeIQ (2-Amino-3,4-dimethylimidazo[4,5-f]quinoline)77094-11-2
MeIQx (2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline)77500-04-0
Melphalan 148-82-3
Menotropins 9002-68-0
Mepanipyrim 110235-47-7
Meprobamate 57-53-4
2-Mercaptobenzothiazole 149-30-4
Mercaptopurine 6112-76-1
Mercury and compounds
Merphalan 531-76-0
Mestranol 72-33-3
Metam potassium 137-41-7
Methacycline hydrochloride Developmental3963-95-9January 1, 1991
Metham sodium 137-42-8
Methanol 67-56-1
Methazole 20354-26-1
Methimazole 60-56-0
Methotrexate 59-05-2
Methotrexate sodium 15475-56-6
5-Methoxypsoralen with ultraviolet A therapy484-20-8
8-Methoxypsoralen with ultraviolet A therapy298-81-7
2-Methylaziridine (Propyleneimine)75-55-8
Methylazoxymethanol 590-96-5
Methylazoxymethanol acetate 592-62-1
Methyl bromide as fumigant74-83-9
Methyl carbamate 598-55-0
Methyl chloride 74-87-3
3-Methylcholanthrene 56-49-5
5-Methylchrysene 3697-24-3
4,4'-Methylene bis(2-chloroaniline) Cancer101-14-4July 1, 1987
4,4'-Methylene bis(N,N-dimethyl)benzenamine 101-61-1
4,4'-Methylene bis(2-methylaniline) 838-88-0
4,4'-Methylenedianiline 101-77-9
4,4'-Methylenedianiline dihydrochloride 13552-44-8
Methyleugenol 93-15-2
2-Methylimidazole 693-98-1
4-Methylimidazole 822-36-6
Methyl iodide 74-88-4
Methyl isobutyl ketone (MIBK)108-10-1
Methyl isocyanate (MIC)624-83-9
Methyl mercury and compoundsDevelopmental

Cancer

July 1, 1987

May 1, 1996

Methyl methanesulfonate 66-27-3
Methyl-n-butyl ketone 591-78-6
2-Methyl-1-nitroanthraquinone 129-15-7
N-Methyl-N'-nitro-N-nitrosoguanidine 70-25-7
N-Methylolacrylamide 924-42-5
N-Methylpyrrolidone 872-50-4
α-Methyl styrene (alpha-Methylstyrene)98-83-9
Methyltestosterone 58-18-4
Methylthiouracil 56-04-2
Metiram 9006-42-2
Metronidazole 443-48-1
Michler's ketone 90-94-8
Midazolam hydrochloride 59467-96-8
Minocycline hydrochloride 13614-98-7
Mirex 2385-85-5
Misoprostol 59122-46-2
Mitomycin C 50-07-7
Mitoxantrone hydrochloride 70476-82-3
Molybdenum trioxide 1313-27-5
Molinate 2212-67-1
MON 4660 (dichloroacetyl-1-oxa-4-azaspiro(4,5)-decane)71526-07-3
MON 13900 (furilazole)121776-33-8
3-Monochloropropane-1,2-diol (3-MCDP)96-24-2
Monocrotaline 315-22-0
MOPP (vincristine-prednisone-nitrogen mustard-procarbazine mixture)113803-47-7
5-(Morpholinomethyl)-3-[(5-nitrofurfurylidene)-amino]-2-oxazolidinone 139-91-3
Mustard Gas 505-60-2
MX (3-chloro-4-dichloromethyl-5-hydroxy-2(5H)-furanone)Cancer77439-76-0December 22, 2000
Myclobutanil 88671-89-0
Beta-Myrcene 123-35-3
Nabam 142-59-6
Nafarelin acetate 86220-42-0
Nafenopin 3771-19-5
Nalidixic acid 389-08-2
Naphthalene 91-20-3
1-Naphthylamine 134-32-7
2-Naphthylamine 91-59-8
Neomycin sulfate 1405-10-3
Netilmicin sulfate 56391-57-2
Nickel (Metallic)7440-02-0
Nickel acetate 373-02-4
Nickel carbonate 3333-67-3
Nickel carbonyl 13463-39-3
Nickel (soluble compounds)
Nickel hydroxide 12054-48-7; 12125-56-3
Nickelocene 1271-28-9
Nickel oxide 1313-99-1
Nickel refinery dust from the pyrometallurgical process
Nickel subsulfide 12035-72-2
Nicotine 54-11-5
Nifedipine 21829-25-4
Nimodipine 66085-59-4
Niridazole 61-57-4
Nitrapyrin 1929-82-4
Nitrilotriacetic acid 139-13-9
Nitrilotriacetic acid, trisodium salt monohydrate 18662-53-8
5-Nitroacenaphthene 602-87-9
o-Nitroanisole 91-23-6
Nitrobenzene 98-95-3
4-Nitrobiphenyl 92-93-3
6-Nitrochrysene Cancer7496-02-8October 1, 1990
Nitrofen (technical grade)1836-75-5
2-Nitrofluorene Cancer607-57-8October 1, 1990
Nitrofurantoin 67-20-9
Nitrofurazone 59-87-0
1-[(5-Nitrofurfurylidene)-amino]-2-imidazolidinone555-84-0
N-[4-(5-Nitro-2-furyl)-2-thiazolyl]acetamide531-82-8
Nitrogen mustard (Mechlorethamine)51-75-2
Nitrogen mustard hydrochloride (Mechlorethamine hydrochloride)55-86-7
Nitrogen mustard N-oxide Cancer126-85-2
Nitrogen mustard N-oxide hydrochloride Cancer302-70-5
Nitromethane Cancer75-52-5May 1, 1997
2-Nitropropane Cancer79-46-9
1-Nitropyrene Cancer5522-43-0October 1, 1990
4-Nitropyrene Cancer57835-92-4October 1, 1990
N,N-Dimethylformamide Cancer68-12-2
N-Nitrosodi-n-butylamine Cancer924-16-3
N-Nitrosodiethanolamine Cancer1116-54-7
N-Nitrosodiethylamine Cancer55-18-5
N-Nitrosodimethylamine Cancer62-75-9
p-Nitrosodiphenylamine Cancer156-10-5
N-Nitrosodiphenylamine Cancer86-30-6
N-Nitrosodi-n-propylamine 621-64-7
N-Nitroso-N-ethylurea 759-73-9
N-Nitrosohexamethyleneimine 932-83-2
3-(N-Nitrosmethylamino) propionitrile 60153-49-3
4-(N-Nitrosomethylamino)-1-(3-pyridyl)-1-butanone 64091-91-4
N-Nitrosomethyl-n-butylamine 7068-83-9
N-Nitrosomethyl-n-decylamine 75881-22-0
N-Nitrosomethyl-n-dodecylamine 55090-44-3
N-Nitrosomethylethylamine 10595-95-6
N-Nitrosomethyl-n-heptylamine 16338-99-1
N-Nitrosomethyl-n-hexylamine 28538-70-7
N-Nitrosomethyl-n-nonylamine 75881-19-5
N-Nitrosomethyl-n-octylamine 34423-54-6
N-Nitrosomethyl-n-pentylamine 13256-07-0
N-Nitrosomethyl-n-propylamine 924-46-9
N-Nitrosomethyl-n-tetradecylamine 75881-20-8
N-Nitrosomethyl-n-undecylamine 68107-26-6
N-Nitroso-N-methylurea 684-93-5
N-Nitroso-N-methylurethane 615-53-2
N-Nitrosomethylvinylamine 4549-40-0
N-Nitrosomorpholine 59-89-2
N-Nitrosonornicotine 16543-55-8
N-Nitrosopiperidine 100-75-4
N-Nitrosopyrrolidine 930-55-2
N-Nitrososarcosine 13256-22-9
o-Nitrotoluene 88-72-2
Nitrous oxide 10024-97-2
Norethisterone (Norethindrone)68-22-4
Norethisterone acetate (Norethindrone acetate)51-98-9
Norethynodrel 68-23-5
Norgestrel 6533-00-2
Ochratoxin A 303-47-9
Oil Orange SS 2646-17-5
Oral contraceptives, combined or sequential
Oryzalin 19044-88-3
Oxadiazon 19666-30-9
Oxazepam 604-75-1
Oxydemeton methyl 301-12-2
Oxymetholone Cancer

Developmental

434-07-1January 1, 1988

May 1, 1997

Oxytetracycline (internal use)Developmental79-57-2January 1, 1991
Oxytetracycline hydrochloride 2058-46-0
Oxythioquinox (Chinomethionat)2439-01-2
Paclitaxel 33069-62-4
Palygorskite fibers (> 5 μm in length)12174-11-7
Panfuran S 794-93-4
Paramethadione 115-67-3
Parathion 56-38-2
Penicillamine Developmental52-67-5January 1, 1991
Pentabromodiphenyl ether mixture [DE-71 (technical grade)]
Pentachlorophenol 87-86-5
Pentachlorophenol and by-products of its synthesis (complex mixture)
Pentobarbital sodium 57-33-0
Pentosan polysulfate sodium
Pentostatin 53910-25-1
Perfluorooctane sulfonate (PFOS)1763-23-1
Perfluorooctanoic acid (PFOA)335-67-1
Pertuzumab Developmental380610-27-5January 27, 2017
Phenacemide 63-98-9
Phenacetin (in analgesic mixtures)Cancer62-44-2
Phenazopyridine 94-78-0
Phenazopyridine hydrochloride 136-40-3
Phenesterin 3546-10-9
Phenobarbital 50-06-6
Phenolphthalein 77-09-8
Phenoxybenzamine 59-96-1
Phenoxybenzamine hydrochloride 63-92-3
Phenprocoumon 435-97-2
o-Phenylenediamine and its salts95-54-5
Phenyl glycidyl ether Cancer122-60-1October 1, 1990
Phenylhydrazine and its salts
o-Phenylphenate, sodium 132-27-4
o-Phenylphenol 90-43-7
Phenylphosphine 638-21-1
PhiP (2-Amino-1-methyl-6-phenylimidazol[4,5-b]pyridine)105650-23-5
Pimozide 2062-78-4
Pioglitazone 111025-46-8
Pipobroman 54-91-1
Pirimicarb 23103-98-2
Plicamycin 18378-89-7
Polybrominated biphenyls
Polychlorinated biphenyls Cancer

Developmental

October 1, 1989

January 1, 1991

Polychlorinated biphenyls (containing 60 or more percent chlorine by molecular weight)
Polychlorinated dibenzo-p-dioxins
Polychlorinated dibenzofurans
Polygeenan 53973-98-1
Ponceau MX 3761-53-3
Ponceau 3R 3564-09-8
Potassium bromate 7758-01-2
Potassium dimethyldithiocarbamate 128-03-0
Pravastatin sodium 81131-70-6
Prednisolone sodium phosphate 125-02-0
Primidone 125-33-7
Procarbazine 671-16-9
Procarbazine hydrochloride 366-70-1
Procymidone 32809-16-8
Progesterone 57-83-0
Pronamide 23950-58-5
Propachlor 1918-16-7
1,3-Propane sultone 1120-71-4
Propargite 2312-35-8
Propazine 139-40-2
beta-Propiolactone 57-57-8
Propoxur 114-26-1
Propylene glycol mono-t-butyl ether 57018-52-7
Propylene oxide 75-56-9
Propylthiouracil 51-52-5
Pulegone 89-82-7
Pymetrozine 123312-89-0
Pyridine 110-86-1
Pyrimethamine 58-14-0
Quazepam 36735-22-5
Quinoline and its strong acid salts
Quizalofop-ethyl 76578-14-8
Radionuclides
Reserpine 50-55-5
Residual (heavy) fuel oils CancerOctober 1, 1990
Resmethrin 10453-86-8
Retinol/retinyl esters [refer 1]
Ribavirin 36791-04-5
Riddelliine 23246-96-0
Rifampin 13292-46-1
Safrole 94-59-7
Salted fish, Chinese-style
Secobarbital sodium 309-43-3
Sedaxane 874967-67-6
Selenium sulfide 7446-34-6
Sermorelin acetate
Shale oils 68308-34-9
Silica, crystalline (airborne particles of respirable size)
Silicon carbide whiskers
Simazine 122-34-9
Sodium dimethyldithiocarbamate 128-04-1
Sodium fluoroacetate 62-74-8
Soots, tars, and mineral oils (untreated and mildly treated oils and used engine oils)
Spirodiclofen 148477-71-8
Spironolactone Cancer52-01-7May 1, 1997
Stanozolol Cancer10418-03-8May 1, 1997
Sterigmatocystin Cancer10048-13-2
Streptomycin sulfate Developmental3810-74-0January 1, 1991
Streptozocin (streptozotocin)Developmental

Reproductive toxicity (female, male)

18883-66-4
Strong inorganic acid mists containing sulfuric acidCancer
Styrene Cancer100-42-5
Styrene oxide 96-09-3
Sulfallate 95-06-7
Sulfasalazine (Salicylazosulfapyridine)599-79-1
Sulfur dioxide 7446-09-5
Sulindac 38194-50-2
Talc containing asbestiform fibers
Tamoxifen 10540-29-1
Tamoxifen citrate 54965-24-1
Temazepam 846-50-4
Teniposide 29767-20-2
Terbacil 5902-51-2
Teriparatide 52232-67-4
Terrazole 2593-15-9
Testosterone 58-22-0
Testosterone cypionate 58-20-8
Testosterone enanthate 315-37-7
Tetrabromobisphenol A 79-94-7
3,3',4,4'-Tetrachloroazobenzene 14047-09-7
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD)1746-01-6
1,1,1,2-Tetrachloroethane 630-20-6
1,1,2,2-Tetrachloroethane 79-34-5
Tetrachloroethylene (Perchloroethylene)127-18-4
p-α,α,α-Tetrachlorotoluene 5216-25-1
Tetrachlorvinphos 22248-79-9
Tetracycline (internal use)Developmental60-54-8
Tetracyclines (internal use)Developmental
Tetracycline hydrochloride (internal use)Developmental64-75-5January 1, 1991
Tetrafluoroethylene Cancer116-14-3May 1, 1997
Tetranitromethane 509-14-8July 1, 1990
Thalidomide Developmental50-35-1July 1, 1987
Thioacetamide 62-55-5
Titanium dioxide 13463-67-7
4,4'-Thiodianiline 139-65-1
Thiodicarb 59669-26-0
Thioguanine 154-42-7
Thiophanate methyl 23564-05-8
2-Thiouracil 141-90-2
Thiourea 62-56-6
Thorium dioxide 1314-20-1
Tobacco, oral use of smokeless products
Tobacco smoke
Tobacco smoke (Primary)
Tobramycin sulfate 49842-07-1
Toluene Developmental108-88-3January 1, 1991
Toluene diisocyanate 26471-62-5
o-Toluidine 95-53-4
o-Toluidine hydrochloride 636-21-5
Topiramate 97240-79-4
Toxaphene (Polychlorinated camphenes)8001-35-2
Fusarium toxins
Treosulfan 299-75-2
Triadimefon 43121-43-3
Triamterene 396-01-0
Triazolam 28911-01-5
S,S,S-Tributyl phosphorotrithioate (Tribufos, DEF)78-48-8
Tributyltin methacrylate 2155-70-6
Trichlormethine (Trimustine hydrochloride)817-09-4
Trichloroacetic acid 76-03-9
1,1,1-Trichloroethane 71-55-6
Trichloroethylene 79-01-6
2,4,6-Trichlorophenol 88-06-2
1,2,3-Trichloropropane 96-18-4
Trientine hydrochloride 38260-01-4
Triforine 26644-46-2
Trilostane Developmental13647-35-3
Trimethadione Developmental127-48-0January 1, 1991
2,4,5-Trimethylaniline
Trimethyl phosphate 512-56-1
Trimetrexate glucuronate 82952-64-5
TRIM VX
2,4,6-Trinitrotoluene (TNT)118-96-7
Triphenyltin hydroxide 76-87-9
Tris(1-aziridinyl)phosphine sulfide (Thiotepa)52-24-4
Tris(2-chloroethyl) phosphate 115-96-8
Tris(2,3-dibromopropyl)phosphate 126-72-7
Tris(1,3-dichloro-2-propyl) phosphate (TDCPP)13674-87-8
Trp-P-1 (Tryptophan-P-1)62450-06-0
Trp-P-2 (Tryptophan-P-2)62450-07-1
Trypan blue 72-57-1
Unleaded gasoline
Uracil mustard 66-75-1
Urethane (Ethyl carbamate)51-79-6
Urofollitropin 97048-13-0
Valproate (Valproic acid)Developmental99-66-1July 1, 1987
Vanadium pentoxide (only orthorhombic)1314-62-1
Vinblastine sulfate 143-67-9
Vinclozolin 50471-44-8
Vincristine sulfate 2068-78-2
Vinyl acetate Cancer108-05-4January 3, 2025
Vinyl bromide 593-60-2
Vinyl chloride 75-01-4
4-Vinylcyclohexene 100-40-3
4-Vinyl-1-cyclohexene diepoxide (Vinyl cyclohexenedioxide)106-87-6
Vinyl fluoride Cancer75-02-5May 1, 1997
Vinylidene chloride (1,1-Dichloroethylene)Cancer75-35-4December 29, 2017
Vinyl trichloride (1,1,2-Trichloroethane)Cancer79-00-5October 1, 1990
Vismodegib Developmental

Reproductive toxicity (female, male)

879085-55-9January 27, 2017
Warfarin Developmental81-81-2July 1, 1987
Wood dust CancerDecember 18, 2009
2,6-Xylidine (2,6-Dimethylaniline)Cancer87-62-7January 1, 1991
Zalcitabine Cancer7481-89-2
Zidovudine (AZT)Cancer30516-87-1December 18, 2009
Zileuton Cancer

Developmental Reproductive toxicity (female)

111406-87-2December 22, 2000

Annotation

  1. When in daily dosages in excess of 10,000 IU, or 3,000 retinol equivalents. (NOTE: Retinol/retinyl esters arerequired and essential for maintenance of normal reproductive function. The recommended daily level during pregnancy is 8,000 IU.)

Chemicals that were formerly listed under California Proposition 65

Formerly on Proposition 65 list
Substance CAS Registry NumberDate removed
Bisphenol A (BPA) 80-05-7April 11, 2013
Allyl chloride 107-05-1October 29, 1999
Phenyl glycidyl ether 122-60-1April 4, 2014
α-Methyl styrene 98-83-9April 4, 2014
tert-Amyl methyl ether 994-05-8December 13, 2013
n-Butyl glycidyl ether 2426-08-6April 4, 2014
Chloramphenicol 56-75-7January 4, 2013
Chlorodibromomethane 124-48-1October 29, 1999
Chlorsulfuron 64902-72-3June 6, 2014
Cyclohexanol 108-93-0January 25, 2002
Diaminotoluene (mixed)November 20, 2015
Dienestrol 84-17-3January 4, 2013
Diglycidyl ether 2238-07-5April 4, 2014
2,4-DP (dichloroprop)120-36-5January 25, 2002
Ethyl-tert-butyl ether 637-92-3December 13, 2013
2-Ethylhexanoic acid 149-57-5December 13, 2013
Isosafrole 120-58-1December 8, 2006
Methyl isopropyl ketone 563-80-4April 4, 2014
5-Nitro-o-anisidine 99-59-2December 8, 2006
p,p'-Oxybis(benzenesulfonyl hydrazide)80-51-3December 13, 2013
Saccharin 81-07-2April 6, 2001
Saccharin, sodium 128-44-9January 17, 2003
para-Toluidine 106-49-0October 29, 1999
1,3,5-Triglycidyl-s-triazinetrione 2451-62-9December 13, 2013
Tris(aziridinyl)-p-benzoquinone (Triaziquone)68-76-8December 8, 2006
Zineb 12122-67-7October 29, 1999

Numerical identifier assigned by the Chemical Abstracts Service (CAS)

Comments:

References

  1. The Proposition 65 List
  2. 1 2 Mohan, Geoffrey (2020-07-23). "You see the warnings everywhere. But does Prop. 65 really protect you?". Los Angeles Times . Companies in every sector of the consumer economy now routinely attach warnings for any of the more than 900 chemicals and elements covered by Proposition 65,...