Equilibrative nucleoside transporter 2

SLC29A2
Identifiers
Aliases	SLC29A2 , DER12, ENT2, HNP36, Equilibrative nucleoside transporter 2, solute carrier family 29 member 2
External IDs	OMIM: 602110 MGI: 1345278 HomoloGene: 37493 GeneCards: SLC29A2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	66,372,214 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	5,031,972 bp
RNA expression pattern
	Top expressed in
	gastrocnemius muscle; ; body of tongue; ; vastus lateralis muscle; ; skeletal muscle tissue; ; left ventricle; ; biceps brachii; ; body of stomach; ; body of pancreas; ; triceps brachii muscle; ; thoracic diaphragm;
	Top expressed in
	yolk sac; ; superior frontal gyrus; ; morula; ; secondary oocyte; ; lip; ; cerebellar cortex; ; neural tube; ; skeletal muscle tissue; ; digastric muscle; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleoside transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; basolateral plasma membrane ; integral component of plasma membrane ; nuclear membrane ; nucleolus ; membrane ; nucleus ; presynapse ;
Biological process	nucleoside transport ; cell population proliferation ; nucleoside transmembrane transport ; nucleobase-containing compound metabolic process ; adenine transport ; guanine transport ; uridine transport ; hypoxanthine transport ; thymine transport ; neurotransmitter reuptake ;
	Sources:Amigo / QuickGO
Orthologs
	3177
	13340
	ENSG00000174669
	ENSMUSG00000024891
	Q14542
	Q61672
	NM_001300868 ; NM_001300869 ; NM_001532
	NM_007854
	NP_001287797 ; NP_001287798 ; NP_001523
	NP_031880
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 21, 2023

Equilibrative nucleoside transporter 2 (ENT2) is a protein that in humans is encoded by the SLC29A2 gene.^[5]^[6]^[7]

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Members of the Equilibrative Nucleoside Transporter (ENT) Family are transport proteins that are specific to nucleosides and nucleobases, and are part of the major facilitator superfamily. They generally possess at least 6, typically 10, transmembrane segments (TMSs) and are 300-600 amino acyl residues in length.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000174669 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024891 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA III, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics. 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.
↑ Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem. 273 (9): 5288–93. doi: 10.1074/jbc.273.9.5288 . PMID 9478986.
↑ "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".

Baldwin SA, Beal PR, Yao SY, et al. (2004). "The equilibrative nucleoside transporter family, SLC29". Pflügers Arch. 447 (5): 735–43. doi:10.1007/s00424-003-1103-2. PMID 12838422. S2CID 8817821.
Mangravite LM, Badagnani I, Giacomini KM (2004). "Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney". Eur. J. Pharmacol. 479 (1–3): 269–81. doi:10.1016/j.ejphar.2003.08.076. PMID 14612157.
Williams JB, Lanahan AA (1995). "A mammalian delayed-early response gene encodes HNP36, a novel, conserved nucleolar protein". Biochem. Biophys. Res. Commun. 213 (1): 325–33. doi: 10.1006/bbrc.1995.2133 . PMID 7639753.
Griffiths M, Yao SY, Abidi F, et al. (1998). "Molecular cloning and characterization of a nitrobenzylthioinosine-insensitive (ei) equilibrative nucleoside transporter from human placenta". Biochem. J. 328 (3): 739–43. doi:10.1042/bj3280739. PMC 1218980 . PMID 9396714.
Yao SY, Ng AM, Vickers MF, et al. (2002). "Functional and molecular characterization of nucleobase transport by recombinant human and rat equilibrative nucleoside transporters 1 and 2. Chimeric constructs reveal a role for the ENT2 helix 5-6 region in nucleobase translocation". J. Biol. Chem. 277 (28): 24938–48. doi: 10.1074/jbc.M200966200 . PMID 12006583.
Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi: 10.1182/blood-2002-07-2236 . PMID 12411296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Mangravite LM, Xiao G, Giacomini KM (2003). "Localization of human equilibrative nucleoside transporters, hENT1 and hENT2, in renal epithelial cells". Am. J. Physiol. Renal Physiol. 284 (5): F902–10. doi:10.1152/ajprenal.00215.2002. PMID 12527552.
Ward JL, Leung GP, Toan SV, Tse CM (2003). "Functional analysis of site-directed glycosylation mutants of the human equilibrative nucleoside transporter-2". Arch. Biochem. Biophys. 411 (1): 19–26. doi:10.1016/S0003-9861(02)00718-X. PMID 12590919.
Szkotak AJ, Ng AM, Man SF, et al. (2003). "Coupling of CFTR-mediated anion secretion to nucleoside transporters and adenosine homeostasis in Calu-3 cells". J. Membr. Biol. 192 (3): 169–79. doi:10.1007/s00232-002-1073-x. PMID 12820662. S2CID 23060872.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi: 10.1002/ijc.20524 . PMID 15386342. S2CID 33828164.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Visser F, Zhang J, Raborn RT, et al. (2005). "Residue 33 of human equilibrative nucleoside transporter 2 is a functionally important component of both the dipyridamole and nucleoside binding sites". Mol. Pharmacol. 67 (4): 1291–8. doi:10.1124/mol.104.005884. PMID 15644498. S2CID 22594104.
Visser F, Baldwin SA, Isaac RE, et al. (2005). "Identification and mutational analysis of amino acid residues involved in dipyridamole interactions with human and Caenorhabditis elegans equilibrative nucleoside transporters". J. Biol. Chem. 280 (12): 11025–34. doi: 10.1074/jbc.M410348200 . PMID 15649894.
Owen RP, Lagpacan LL, Taylor TR, et al. (2006). "Functional characterization and haplotype analysis of polymorphisms in the human equilibrative nucleoside transporter, ENT2". Drug Metab. Dispos. 34 (1): 12–5. doi:10.1124/dmd.105.006270. PMID 16214850. S2CID 6396393.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000174669 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024891 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9192854-5] Williams JB, Rexer B, Sirripurapu S, John S, Goldstein R, Phillips JA III, Haley LL, Sait SN, Shows TB, Smith CM, Gerhard DS (Sep 1997). "The human HNP36 gene is localized to chromosome 11q13 and produces alternative transcripts that are not mutated in multiple endocrine neoplasia, type 1 (MEN I) syndrome". Genomics. 42 (2): 325–30. doi:10.1006/geno.1997.4751. PMID 9192854.

[pmid9478986-6] Crawford CR, Patel DH, Naeve C, Belt JA (Mar 1998). "Cloning of the human equilibrative, nitrobenzylmercaptopurine riboside (NBMPR)-insensitive nucleoside transporter ei by functional expression in a transport-deficient cell line". J Biol Chem. 273 (9): 5288–93. doi: 10.1074/jbc.273.9.5288 . PMID 9478986.

[entrez-7] "Entrez Gene: SLC29A2 solute carrier family 29 (nucleoside transporters), member 2".

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Equilibrative nucleoside transporter 2

Contents

See also

Related Research Articles

References

Further reading