Concentrative nucleoside transporter 1

SLC28A1
Identifiers
Aliases	SLC28A1 , CNT1, HCNT1, Concentrative nucleoside transporter 1, solute carrier family 28 member 1, URCTU
External IDs	OMIM: 606207 MGI: 3605073 HomoloGene: 37902 GeneCards: SLC28A1
Gene location (Human)
Chr.	Chromosome 15 (human)
End	84,945,798 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	80,820,164 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; duodenum; ; jejunal mucosa; ; kidney tubule; ; renal medulla; ; skeletal muscle tissue; ; gastrocnemius muscle; ; ventricle; ; left ventricle;
	Top expressed in
	proximal tubule; ; duodenum; ; kidney; ; neck; ; pharynx; ; bone marrow; ; secondary oocyte; ; yolk sac; ; jejunum; ; colon;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleoside transmembrane transporter activity ; pyrimidine- and adenine-specific:sodium symporter activity ; nucleoside:sodium symporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; membrane ; integral component of plasma membrane ;
Biological process	pyrimidine nucleobase transport ; nucleoside transport ; pyrimidine-containing compound transmembrane transport ; nucleoside transmembrane transport ; nucleobase-containing compound metabolic process ; purine nucleobase transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	9154
	434203
	ENSG00000156222
	ENSMUSG00000025726
	O00337
	E9PXX9
NM_001287761 ; NM_001287762 ; NM_004213 ; NM_201651 ; NM_001321721 ;
	NM_001321722
	NM_001004184
NP_001274690 ; NP_001274691 ; NP_001308650 ; NP_001308651 ; NP_004204 ;
	NP_964014
	NP_001004184
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 29, 2023

Concentrative nucleoside transporter 1 (CNT1) is a protein that in humans is encoded by the SLC28A1 gene.^[5]^[6]

Related Research Articles

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The organic anion transporter 1 (OAT1) also known as solute carrier family 22 member 6 (SLC22A6) is a protein that in humans is encoded by the SLC22A6 gene. It is a member of the organic anion transporter (OAT) family of proteins. OAT1 is a transmembrane protein that is expressed in the brain, the placenta, the eyes, smooth muscles, and the basolateral membrane of proximal tubular cells of the kidneys. It plays a central role in renal organic anion transport. Along with OAT3, OAT1 mediates the uptake of a wide range of relatively small and hydrophilic organic anions from plasma into the cytoplasm of the proximal tubular cells of the kidneys. From there, these substrates are transported into the lumen of the nephrons of the kidneys for excretion. OAT1 homologs have been identified in rats, mice, rabbits, pigs, flounders, and nematodes.

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Human concentrative nucleoside transporters include SLC28A1, SLC28A2 and SLC28A3 proteins. SLC28A2 is a purine-specific Na⁺-nucleoside cotransporter localised to the bile canalicular membrane. SLC28A1 is a Na⁺-dependent nucleoside transporter selective for pyrimidine nucleosides and adenosine. It also transports the anti-viral nucleoside analogues Zidovudine and Zalcitabine.

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156222 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025726 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD (Apr 1997). "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)". Am J Physiol. 272 (2 Pt 1): C707–14. doi:10.1152/ajpcell.1997.272.2.C707. PMID 9124315.
↑ "Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1".

Ritzel MW, Ng AM, Yao SY, et al. (2001). "Recent molecular advances in studies of the concentrative Na+-dependent nucleoside transporter (CNT) family: identification and characterization of novel human and mouse proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib)". Mol. Membr. Biol. 18 (1): 65–72. doi:10.1080/09687680118530. PMID 11396613. S2CID 218896128.
Ritzel MW, Yao SY, Ng AM, et al. (1999). "Molecular cloning, functional expression and chromosomal localization of a cDNA encoding a human Na+/nucleoside cotransporter (hCNT2) selective for purine nucleosides and uridine". Mol. Membr. Biol. 15 (4): 203–11. doi: 10.3109/09687689709044322 . PMID 10087507.
Loewen SK, Ng AM, Yao SY, et al. (1999). "Identification of amino acid residues responsible for the pyrimidine and purine nucleoside specificities of human concentrative Na(+) nucleoside cotransporters hCNT1 and hCNT2". J. Biol. Chem. 274 (35): 24475–84. doi: 10.1074/jbc.274.35.24475 . PMID 10455109.
Mata JF, García-Manteiga JM, Lostao MP, et al. (2001). "Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug". Mol. Pharmacol. 59 (6): 1542–8. doi:10.1124/mol.59.6.1542. hdl: 10171/21116 . PMID 11353816.
Lai Y, Bakken AH, Unadkat JD (2002). "Simultaneous expression of hCNT1-CFP and hENT1-YFP in Madin-Darby canine kidney cells. Localization and vectorial transport studies". J. Biol. Chem. 277 (40): 37711–7. doi: 10.1074/jbc.M204986200 . PMID 12097333.
Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627. S2CID 16195525.
Molina-Arcas M, Bellosillo B, Casado FJ, et al. (2003). "Fludarabine uptake mechanisms in B-cell chronic lymphocytic leukemia". Blood. 101 (6): 2328–34. doi: 10.1182/blood-2002-07-2236 . PMID 12411296.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
García-Manteiga J, Molina-Arcas M, Casado FJ, et al. (2004). "Nucleoside transporter profiles in human pancreatic cancer cells: role of hCNT1 in 2',2'-difluorodeoxycytidine- induced cytotoxicity". Clin. Cancer Res. 9 (13): 5000–8. PMID 14581375.
Loewen SK, Yao SY, Slugoski MD, et al. (2004). "Transport of physiological nucleosides and anti-viral and anti-neoplastic nucleoside drugs by recombinant Escherichia coli nucleoside-H(+) cotransporter (NupC) produced in Xenopus laevis oocytes". Mol. Membr. Biol. 21 (1): 1–10. doi: 10.1080/0968768031000140836 . PMID 14668133. S2CID 11973712.
Gray JH, Mangravite LM, Owen RP, et al. (2004). "Functional and genetic diversity in the concentrative nucleoside transporter, CNT1, in human populations". Mol. Pharmacol. 65 (3): 512–9. doi:10.1124/mol.65.3.512. PMID 14978229. S2CID 1788715.
Farré X, Guillén-Gómez E, Sánchez L, et al. (2004). "Expression of the nucleoside-derived drug transporters hCNT1, hENT1 and hENT2 in gynecologic tumors". Int. J. Cancer. 112 (6): 959–66. doi: 10.1002/ijc.20524 . PMID 15386342. S2CID 33828164.
Lai Y, Lee EW, Ton CC, et al. (2005). "Conserved residues F316 and G476 in the concentrative nucleoside transporter 1 (hCNT1) affect guanosine sensitivity and membrane expression, respectively". Am. J. Physiol., Cell Physiol. 288 (1): C39–45. doi:10.1152/ajpcell.00192.2004. PMID 15456697. S2CID 27633580.
Fernández-Veledo S, Jover R, Casado FJ, et al. (2007). "Transcription factors involved in the expression of SLC28 genes in human liver parenchymal cells". Biochem. Biophys. Res. Commun. 353 (2): 381–8. doi:10.1016/j.bbrc.2006.12.021. PMID 17187757.
Slugoski MD, Loewen SK, Ng AM, et al. (2007). "Specific mutations in transmembrane helix 8 of human concentrative Na+/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling". Biochemistry. 46 (6): 1684–93. doi:10.1021/bi061692s. PMID 17279631.
Smith KM, Slugoski MD, Cass CE, et al. (2007). "Cation coupling properties of human concentrative nucleoside transporters hCNT1, hCNT2 and hCNT3". Mol. Membr. Biol. 24 (1): 53–64. doi:10.1080/09687860600942534. PMID 17453413. S2CID 20779608.
Guallar JP, Cano-Soldado P, Aymerich I, et al. (2007). "Altered expression of nucleoside transporter genes (SLC28 and SLC29) in adipose tissue from HIV-1-infected patients". Antivir. Ther. (Lond.). 12 (6): 853–63. doi: 10.1177/135965350701200601 . PMID 17926640. S2CID 19447232.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156222 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025726 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9124315-5] Ritzel MW, Yao SY, Huang MY, Elliott JF, Cass CE, Young JD (Apr 1997). "Molecular cloning and functional expression of cDNAs encoding a human Na+-nucleoside cotransporter (hCNT1)". Am J Physiol. 272 (2 Pt 1): C707–14. doi:10.1152/ajpcell.1997.272.2.C707. PMID 9124315.

[entrez-6] "Entrez Gene: SLC28A1 solute carrier family 28 (sodium-coupled nucleoside transporter), member 1".

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Concentrative nucleoside transporter 1

Contents

See also

Related Research Articles

References

Further reading