| Date | Constituency | c/u | Former Incumbent | Winner | Cause |
|---|
| 1 April 1715 | Andover | u* | John Wallop | James Brudenell | Chose to sit for Hampshire |
| 5 April 1715 | East Grinstead | u | Spencer Compton | The Viscount Shannon | Chose to sit for Sussex |
| 7 April 1715 | Portsmouth | u* | Sir Charles Wager | Sir Charles Wager | Comptroller of the Navy |
| 16 April 1715 | Aldborough | u | James Stanhope | William Monson | Chose to sit for Cockermouth |
| 18 April 1715 | Lymington | u | Lord William Powlett | Richard Chaundler | Chose to sit for Winchester |
| 18 April 1715 | Wareham | u | George Pitt | George Pitt, junior | Chose to sit for Hampshire |
| 21 April 1715 | Thirsk | u* | Thomas Frankland | Thomas Frankland | Clerk of the Deliveries of the Ordnance |
| 27 April 1715 | Carnarvonshire | u* | William Griffith | John Griffith | Death |
| 30 April 1715 | Aylesbury | u | John Deacle | Trevor Hill | Chose to sit for Evesham |
| 3 May 1715 | Haverfordwest | c | John Laugharne | Sir George Barlow | Death |
| Sir George Barlow | John Barlow | By-election result reversed on petition 4 July 1715 |
| 3 May 1715 | St Germans | u | Waller Bacon | Lord Stanhope | Chose to sit for Norwich |
| 19 May 1715 | Shaftesbury | c* | Edward Nicholas | Edward Nicholas | On Petition both incumbents were unseated and replaced by William Benson. A by-election was held for the second seat. |
| Samuel Rush |
| 25 May 1715 | Oxfordshire | u | Francis Clerke | James Herbert | Death |
| 27 May 1715 | Renfrewshire | u | Sir Robert Pollock | Sir Robert Pollock | Governor of Fort William |
| 31 May 1715 | Essex | c* | Thomas Midleton | William Harvey | Death |
| William Harvey | Robert Honywood | By-election results reversed on petition 18 May 1716 |
| 7 June 1715 | Northampton | c* | George Montagu | William Wilmer | Succeeded to a peerage |
| 28 September 1715 | Kent | u | Mildmay Fane | John Fane | Death |
| 7 October 1715 | Ayrshire | u* | John Montgomerie | John Montgomerie | Accepted a Commission in the Army |
| 11 October 1715 | Worcester | u* | Thomas Wylde | Thomas Wylde | Irish Revenue Commissioner |
| 2 November 1715 | Rutland | u* | Lord Finch | Lord Finch | Junior Lord of the Treasury |
| 5 November 1715 | Wenlock | u | Thomas Newport | Thomas Newport | Junior Lord of the Treasury |
| 7 November 1715 | Petersfield | u | Leonard Bilson | Samuel Pargiter Fuller | Death |
| 8 November 1715 | King's Lynn | u* | Robert Walpole | Robert Walpole | First Lord of the Treasury and Chancellor of the Exchequer |
| 17 November 1715 | Winchester | u* | Lord William Powlett | Lord William Powlett | Teller of the Exchequer |
| 21 November 1715 | Shrewsbury | u | Thomas Jones | Andrew Corbet | Death |
| 30 November 1715 | Surrey | u | Sir Richard Onslow | Thomas Onslow | Resignation (Teller of the Exchequer) |
| 2 December 1715 | Bedford | u* | William Farrer | William Farrer | Master of St Katharine's by the Tower |
| 2 December 1715 | Downton | u* | John Eyre | Giles Eyre | Death |
| 7 December 1715 | Bletchingley | u* | Thomas Onslow | William Clayton | Out-Ranger of Windsor Forest |
| 27 December 1715 | Newark-on-Trent | c* | Conyers Darcy | Conyers Darcy | Commissioner exercising the office of Master of the Horse |
| 2 January 1716 | Carmarthen | u* | Richard Vaughan | Richard Vaughan | Chief Justice of the Carmarthen Circuit |
| 14 January 1716 | Midhurst | u | John Fortescue Aland | John Fortescue Alan | Solicitor General for England and Wales |
| 24 January 1716 | Bere Alston | u | Lawrence Carter | Lawrence Carter | King's Counsel |
| 26 January 1716 | Malmesbury | u* | Joseph Addison | Joseph Addison | Lord of Trade |
| 2 February 1716 | Northumberland | u | Thomas Forster | Francis Blake Delaval | Expelled for supporting the Jacobite Rising |
| 22 February 1716 | Glamorganshire | u* | Robert Jones | Sir Charles Kemeys | Death |
| 24 February 1716 | Glasgow Burghs | u* | Thomas Smith | Daniel Campbell | Death |
| 17 March 1716 | Honiton | c* | Sir William Courtenay | Sir William Pole | Chose to sit for Devon |
| 19 March 1716 | Castle Rising | u* | William Feilding | William Feilding | First Clerk Comptroller of the Green Cloth |
| 3 April 1716 | Andover | u* | James Brudenell | James Brudenell | Master of the Jewel Office |
| 6 June 1716 | Reading | c | Robert Clarges | Charles Cadogan | Void Election |
| c* | Felix Calvert | Owen Buckingham |
| 27 June 1716 | Wells | c | William Coward | Thomas Strangways Horner | Death |
| Thomas Strangways Horner | John Dodd | By-election results reversed on petition 12 April 1717 |
| 28 June 1716 | Eye | u* | Edward Hopkins | Edward Hopkins | Irish Revenue Commissioner |
| 30 June 1716 | Denbighshire | c* | Sir Richard Myddelton | Watkin Williams | Death |
| 30 June 1716 | Maidstone | c | Sir Robert Marsham | Sir Barnham Rider | Elevated to the peerage |
| 2 July 1716 | New Woodstock | u* | William Cadogan | William Clayton | Elevated to the peerage |
| 4 July 1716 | Buckinghamshire | u* | Richard Hampden | Richard Hampden | Teller of the Exchequer |
| 9 July 1716 | Brackley | u* | Paul Methuen | Paul Methuen | Southern Secretary |
| 11 July 1716 | Plympton Erle | u* | Richard Edgcumbe | Richard Edgcumbe | Junior Lord of the Treasury |
| 16 July 1716 | Lancaster | u* | William Heysham | William Heysham, jnr | Death |
| 16 July 1716 | Wenlock | u* | Thomas Newport | Sir Humphrey Briggs | Elevated to the peerage |
| 30 July 1716 | Forfarshire | u* | John Carnegie | James Scott | Expelled for supporting the Jacobite Rising |
| 3 August 1716 | Old Sarum | u* | Thomas Pitt | Sir William Strickland | Resignation (Governor of Jamaica) |
| 29 January 1717 | Cardiganshire | u | Lewis Pryse | Owen Brigstocke | Expulsion for refusing to take loyalty oaths |
| 27 February 1717 | Midhurst | u* | John Fortescue Aland | The Lord Midleton | Resignation (Baron of the Exchequer) |
| 28 February 1717 | Ipswich | u* | Sir William Thompson | Sir William Thompson | Solicitor General for England and Wales |
| 28 February 1717 | Seaford | u* | Sir William Ashburnham | Henry Pelham | Resignation (Commissioner of the Alienation Office) |
| 2 March 1717 | Weymouth and Melcombe Regis | u | John Baker | Edward Harrison | Death |
| 5 March 1717 | Richmond | u* | Thomas Yorke | John Yorke | Death |
| 6 March 1717 | Herefordshire | u | Sir Thomas Morgan | Sir Hungerford Hoskyns | Death |
| 9 March 1717 | Christchurch | u* | William Ettrick | Francis Gwyn | Death |
| 12 March 1717 | Hereford | c* | The Viscount Scudamore | Herbert Rudhale Westfaling | Death |
| 13 March 1717 | Kingston-upon-Hull | u* | William Maister | Nathaniel Rogers | Death |
| 15 March 1717 | Reigate | c | Sir John Parsons | William Jordan | Death |
| 19 March 1717 | Leominster | c* | The Lord Coningsby | George Caswall | Became a British Peer |
| 11 April 1717 | Minehead | c | Sir William Wyndham | Samuel Edwin | Void Election |
| Sir John Trevelyan | Thomas Gage |
| Samuel Edwin | Sir John Trevelyan | By-election results reversed on petition 23 May 1717 |
| Thomas Gage | James Milner |
| 12 April 1717 | New Woodstock | u | Sir Thomas Wheate | Sir Thomas Wheate | Storekeeper of the Ordnance |
| 16 April 1717 | Morpeth | u* | The Viscount Castlecomer | George Carpenter | Chose to sit for Ripon |
| 18 April 1717 | Cambridgeshire | u | John Jenyns | Robert Clarke | Death |
| 22 April 1717 | Bridport | u | William Coventry | William Coventry | Second Clerk Comptroller of the Green Cloth |
| 22 April 1717 | Totnes | u | Arthur Champernowne | Sir John Germain | Death |
| 22 April 1717 | Tregony | u* | James Craggs the Younger | James Craggs the Younger | Secretary at War |
| 24 April 1717 | Dover | u* | Matthew Aylmer | Matthew Aylmer | Naval Lord |
| 25 April 1717 | Malmesbury | u | Joseph Addison | Joseph Addison | Southern Secretary |
| 25 April 1717 | Newport I.o.W. | u | Anthony Morgan | James Stanhope | Chose to sit for Yarmouth |
| 25 April 1717 | Stafford | u | William Richard Chetwynd | William Richard Chetwynd | Lord of the Admiralty |
| 26 April 1717 | Arundel | u | Thomas Micklethwaite | Thomas Micklethwaite | Junior Lord of the Treasury |
| 29 April 1717 | Cockermouth | c* | James Stanhope | Thomas Pengelly | First Lord of the Treasury and Chancellor of the Exchequer |
| 1 May 1717 | Hampshire | u | John Wallop | John Wallop | Junior Lord of the Treasury |
| 2 May 1717 | Berwickshire | u* | George Baillie | George Baillie | Junior Lord of the Treasury |
| 2 May 1717 | Haddingtonshire | u* | John Cockburn | John Cockburn | Lord of the Admiralty |
| 16 May 1717 | Bury St Edmunds | u* | Aubrey Porter | James Reynolds | Death |
| 23 May 1717 | Carmarthenshire | u | Marquess of Winchester | Sir Thomas Stepney | Elevated to the peerage |
| 29 May 1717 | Gloucestershire | c | Matthew Moreton | Matthew Moreton | Vice-Treasurer of Ireland |
| 10 June 1717 | Milborne Port | c(*) | John Cox | Michael Harvey | Death |
| Michael Harvey | Charles Stanhope | By-election results reversed on petition 6 July 1717 |
| 17 June 1717 | Leominster | c | George Caswall | George Caswall | Previous by-election declared void |
| 25 June 1717 | Tewkesbury | u* | Anthony Lechmere | Nicholas Lechmere | Resignation (Receiver-General and Cashier of Customs) |
| 8 July 1717 | Cockermouth | c | Nicholas Lechmere | Lord Percy Seymour | Chancellor of the Duchy of Lancaster (Two MPs elected due to a Double Return) |
| Wilfrid Lawson |
| Lord Percy Seymour | Lord Percy Seymour | Seymour declared elected 18 January 1718 |
| Wilfrid Lawson |
| 10 July 1717 | Amersham | u* | The Viscount Fermanagh | The Viscount Fermanagh | Death |
| 22 July 1717 | Newport I.o.W. | u | James Stanhope | Sir Tristram Dillington | Elevated to the peerage |
| 22 July 1717 | Stockbridge | u* | Martin Bladen | Martin Bladen | Lord of Trade |
| 23 July 1717 | Lewes | u* | Thomas Pelham | Thomas Pelham | Lord of Trade |
| 24 July 1717 | Aldborough | u* | William Jessop | William Jessop | Commissioner and Receiver of the Alienation Office |
| 26 July 1717 | Lymington | u | Sir Joseph Jekyll | Sir Joseph Jekyll | Master of the Rolls |
| 27 July 1717 | West Looe | u | Thomas Maynard | Thomas Maynard | Commissioner for Stores in Minorca |
| 30 July 1717 | Thirsk | u | Ralph Bell | Thomas Pitt | Resignation (Customer of Hull) |
| 8 August 1717 | Fifeshire | u* | Sir John Anstruther | Sir John Anstruther | Master of Work to the Crown of Scotland |
| 9 August 1717 | Truro | u* | Spencer Cowper | Spencer Cowper | Chief Justice of Chester |
| 29 November 1717 | Penryn | u | Hugh Boscawen | Hugh Boscawen | Joint Vice-Treasurer of Ireland |
| 30 November 1717 | Buckingham | u | Abraham Stanyan | Edmund Halsey | Resignation (Clerk of the Privy Council) |
| 3 December 1717 | St Albans | c | William Hale | Joshua Lomax | Death |
| 4 December 1717 | Oxfordshire | u* | Sir Robert Jenkinson | Sir Robert Bankes Jenkinson | Death |
| 4 December 1717 | Oxford University | u* | Sir William Whitelock | George Clarke | Death |
| 9 December 1717 | Bere Alston | u | Horatio Walpole | Edward Carteret | Resignation (Surveyor and Auditor General of the Revenue in America) |
| 13 December 1717 | Ipswich | u* | William Churchill | Francis Negus | Resignation (Bookseller, Bookbinder, and Stationer to the King) |
| 18 December 1717 | Reading | u | Owen Buckingham | Owen Buckingham | Victualling Commissioner |
| 25 December 1717 | Surrey | c | Thomas Onslow | Denzil Onslow | Succeeded to a peerage |
| 26 December 1717 | Launceston | u | John Anstis | John Anstis | Garter King of Arms |
| 31 December 1717 | Guildford | u | Denzil Onslow | Robert Wroth | Out-Ranger of Windsor Forest |
| 31 January 1718 | Boroughbridge | c* | Thomas Wilkinson | Sir Wilfrid Lawson | Resignation (Joint-Receiver General of Land Taxes for Yorkshire, Durham and Northumberland) |
| 22 February 1718 | Barnstaple | u | Sir Arthur Chichester | John Basset | Death |
| 26 February 1718 | Bodmin | u | Francis Robartes | Earl of Burford | Death |
| 4 March 1718 | Haverfordwest | u | John Barlow | Sir John Philipps | Death |
| 4 March 1718 | Worcester | u* | Samuel Swift | Samuel Sandys | Death |
| 19 March 1718 | Tewkesbury | u | Nicholas Lechmere | Nicholas Lechmere | Attorney General for England and Wales |
| 20 March 1718 | Tregony | u | James Craggs the Younger | James Craggs the Younger | Southern Secretary |
| 25 March 1718 | Rochester | u* | Sir John Jennings | Sir John Jennings | Naval Lord |
| 28 March 1718 | Dover | u | Matthew Aylmer | Matthew Aylmer | Master of Greenwich Hospital |
| 28 March 1718 | East Retford | u* | Thomas White | Thomas White | Clerk of the Ordnance |
| 28 March 1718 | Portsmouth | u* | Sir Charles Wager | Sir Charles Wager | Naval Lord |
| 28 March 1718 | Rye | u | Sir John Norris | Sir John Norris | Naval Lord |
| 28 March 1718 | Wareham | u | Thomas Erle | Henry Drax | Resignation (Given a pension) |
| 29 March 1718 | Arundel | u* | Thomas Micklethwaite | Joseph Micklethwaite | Lieutenant-General of the Ordnance and Death |
| 29 March 1718 | New Woodstock | u | William Clayton | William Clayton | Junior Lord of the Treasury |
| 4 April 1718 | Ripon | u | John Aislabie | John Aislabie | Chancellor of the Exchequer |
| 5 April 1718 | Scarborough | u | William Thompson | William Thompson | Warden of the Mint |
| 9 April 1718 | Buckinghamshire | u | Richard Hampden | Richard Hampden | Treasurer of the Navy |
| 24 April 1718 | Lichfield | c(*) | Walter Chetwynd | William Sneyd | Paymaster of Pensions |
| William Sneyd | Walter Chetwynd | By-election results reversed on petition 10 December 1718 |
| 21 November 1718 | Shaftesbury | c(*) | William Benson | William Benson | Surveyor of the King's Works |
| William Benson | Sir Edward des Bouverie | By-election results reversed 24 January 1719 |
| 22 November 1718 | Weobley | c* | Charles Cornewall | Nicholas Philpott | Death |
| 24 November 1718 | Aldeburgh | c* | William Johnson | Samuel Lowe | Death |
| 26 November 1718 | Lostwithiel | u | Thomas Liddell | Edward Eliot | Death |
| 27 November 1718 | Cambridgeshire | u | John Bromley | Francis Whichcote | Death |
| 1 December 1718 | Saltash | u | William Shippen | John Francis Buller | Chose to sit for Newton |
| 1 December 1718 | Corfe Castle | c(*) | William Okeden | Joshua Churchill | Death (Two MPs elected due to a Double Return) |
| John Bankes |
| Joshua Churchill | Joshua Churchill | Churchill declared elected 21 January 1719 |
| John Bankes |
| 2 December 1718 | East Looe | u* | James Bateman | Horatio Walpole | Death |
| 23 December 1718 | Lanarkshire | c* | James Lockhart | Lord Archibald Hamilton | Death |
| 29 December 1718 | Plympton Erle | u* | George Treby | George Treby | Secretary at War |
| 29 December 1718 | Totnes | u* | Sir John Germain | Charles Wills | Death |
| 9 January 1719 | Montgomeryshire | u* | Edward Vaughan | Price Devereux | Death |
| 10 January 1719 | St Germans | u | John Knight | John Knight | Secretary of the Leeward Islands |
| 21 January 1719 | Rutland | u | John Noel | Marquess of Granby | Death |
| 3 February 1719 | Leicester | u | James Winstanley | Thomas Noble | Death |
| 26 March 1719 | Ludlow | u* | Francis Herbert | Sir Robert Raymond | Death |
| 21 April 1719 | Lewes | u* | John Morley Trevor | Philip Yorke | Death |
| 30 April 1719 | Totnes | u* | Charles Wills | Charles Wills | Lieutenant General of the Ordnance |
| 30 November 1719 | Bridport | u* | William Coventry | Dewey Bulkeley | Succeeded to a peerage |
| 30 November 1719 | Malmesbury | u | Joseph Addison | Fleetwood Dormer | Death |
| 1 December 1719 | Wallingford | c | Edmund Dunch | Henry Grey | Death |
| 3 December 1719 | Aldeburgh | c* | Henry Johnson | Walter Plumer | Death |
| 3 December 1719 | Chichester | u | Sir Richard Farington | Henry Kelsall | Death |
| 4 December 1719 | Callington | u* | Samuel Rolle | Thomas Coplestone | Death |
| 5 December 1719 | Ripon | u | The Viscount Castlecomer | William Aislabie | Death |
| 7 December 1719 | Fowey | u* | Henry Vincent | Nicholas Vincent | Death |
| 14 December 1719 | Wells | c* | John Dodd | Thomas Edwards | Death |
| 15 December 1719 | Surrey | c* | Lord Guernsey | John Walter | Succeeded to a peerage |
| 17 December 1719 | Bishop's Castle | u | Richard Harnage | Sir Matthew Decker | Death |
| 17 December 1719 | Leicestershire | c* | Sir Thomas Cave | Lord William Manners | Death |
| 5 January 1720 | Elginshire | u | Alexander Grant | James Brodie | Death |
| 9 January 1720 | Ayr Burghs | u | Charles Oliphant | Thomas Kennedy | Death |
| 25 January 1720 | Richmond | u | Harry Mordaunt | Richard Abell | Death |
| 2 February 1720 | Newark-on-Trent | u | Conyers Darcy | Conyers Darcy | Master of the Household |
| 15 February 1720 | Guildford | u* | Robert Wroth | Arthur Onslow | Death |
| 22 February 1720 | Bath | c | Samuel Trotman | Robert Gay | Death |
| 10 March 1720 | Shropshire | u | Sir Robert Corbet | Sir Robert Corbet | Second Clerk of the Green Cloth |
| 15 March 1720 | Reading | c | Owen Buckingham | Richard Thompson | Death |
| 15 March 1720 | Tregony | u | Sir Edmund Prideaux | Charles Talbot | Death |
| 24 March 1720 | Monmouthshire | u* | John Morgan | John Hanbury | Death |
| 25 March 1720 | Winchelsea | u* | Robert Bristow | Robert Bristow | Second Clerk Comptroller of the Green Cloth |
| 30 March 1720 | Gloucestershire | u* | Thomas Stephens | Henry Berkeley | Death |
| 30 March 1720 | Lewes | u | Philip Yorke | Philip Yorke | Solicitor General for England and Wales |
| 16 April 1720 | Knaresborough | u* | The Earl Mountrath | Richard Arundell | Death |
| 19 April 1720 | Bridgwater | c | George Dodington | William Pitt | Death |
| 20 April 1720 | Chippenham | u | Giles Earle | Giles Earle | First Clerk Comptroller of the Green Cloth |
| 21 April 1720 | Reigate | u | William Jordan | Thomas Jordan | Death |
| 23 April 1720 | Dorchester | c | Henry Trenchard | Robert Browne | Death |
| Robert Browne | Abraham Janssen | By-election results reversed 18 May 1720 |
| 6 May 1720 | Hindon | u | Reynolds Calthorpe | John Pitt | Death |
| 9 May 1720 | Sandwich | c* | Sir Henry Oxenden | Sir George Oxenden | Death |
| 11 May 1720 | Haddington Burghs | u | Sir David Dalrymple | Sir David Dalrymple | Auditor of the Exchequer in Scotland |
| 13 May 1720 | Monmouth | u | William Bray | Andrews Windsor | Death |
| 21 May 1720 | Ludlow | u | Sir Robert Raymond | Sir Robert Raymond | Attorney General for England and Wales |
| 25 May 1720 | Nottingham | u* | John Plumptre | John Plumptre | Treasurer of the Ordnance |
| 7 June 1720 | Seaford | u* | Henry Pelham | Henry Pelham | Treasurer of the Chamber |
| 11 June 1720 | Corfe Castle | u | Joshua Churchill | Joshua Churchill | Victualling Commissioner |
| 11 June 1720 | Seaford | u* | Sir Gregory Page | Francis Chamberlayne | Death |
| 14 June 1720 | Old Sarum | u | Sir William Strickland | Sir William Strickland | Muster-Master General |
| 18 June 1720 | Boroughbridge | u | Sir Wilfrid Lawson | Sir Wilfrid Lawson | Groom of the Bedchamber |
| 18 June 1720 | Bossiney | u | Henry Cartwright | Henry Cartwright | Victualling Commissioner |
| 22 June 1720 | Gloucestershire | u | Matthew Moreton | Edmund Bray | Elevated to the peerage |
| 22 June 1720 | Hampshire | u* | John Wallop | Lord Nassau Powlett | Elevated to the peerage |
| 22 June 1720 | King's Lynn | u* | Robert Walpole | Robert Walpole | Paymaster of the Forces |
| Sir Charles Turner | Sir Charles Turner | Junior Lord of the Treasury |
| 23 June 1720 | Castle Rising | u* | Charles Churchill | Charles Churchill | Governor of Royal Hospital Chelsea |
| 23 June 1720 | Plympton Erle | u* | Richard Edgcumbe | Richard Edgcumbe | Junior Lord of the Treasury |
| 24 June 1720 | Brackley | u* | Paul Methuen | Paul Methuen | Comptroller of the Household |
| 24 June 1720 | Penryn | u | Hugh Boscawen | Viscount Rialton | Elevated to the peerage |
| 25 June 1720 | Lostwithiel | u | Edward Eliot | John Newsham | Resignation (Commissioner of Excise) |
| 11 July 1720 | Kingston-upon-Hull | u* | Sir William St Quintin | Sir William St Quintin | Joint Vice-Treasurer of Ireland |
| 19 July 1720 | Heytesbury | u* | Edward Ashe | Edward Ashe | Lord of Trade |
| 7 December 1720 | Boston | c* | Richard Wynn | Richard Ellys | Death |
| 14 December 1720 | Rochester | u* | Sir John Jennings | Sir John Jennings | Governor of Greenwich Hospital |
| 19 December 1720 | Cambridge University | c* | Thomas Paske | Thomas Willoughby | Death |
| 19 December 1720 | Plymouth | u | Sir George Byng | Sir George Byng | Treasurer of the Navy |
| 20 December 1720 | Dover | u* | The Lord Aylmer | George Berkeley | Death |
| Philip Papillon | Henry Furnese | Resignation (Receiver of the Stamp Duties) |
| 29 December 1720 | Elginshire | u* | James Brodie | Alexander Brodie | Death |
| 29 December 1720 | Staffordshire | u* | William Ward | William Leveson Gower | Death |
| 3 January 1721 | Lincolnshire | c* | Sir Willoughby Hickman | Sir William Massingberd | Death |
| 1 February 1721 | Cricklade | c | Jacob Sawbridge | Matthew Ducie Moreton | Expulsion (Director of the South Sea Company) |
| 8 February 1721 | Devizes | u* | Francis Eyles | Benjamin Haskins Stiles | Expulsion (Director of the South Sea Company) |
| 10 February 1721 | Yarmouth | u | Sir Theodore Janssen | William Plumer | Expulsion (Director of the South Sea Company) |
| 11 February 1721 | Great Grimsby | c | Sir Robert Chaplin | Arthur Moore | Expulsion (Director of the South Sea Company) |
| 25 February 1721 | Corfe Castle | u | Joshua Churchill | John Bond | Death |
| 6 March 1721 | Worcestershire | u* | Thomas Vernon | Sir Thomas Lyttelton | Death |
| 13 March 1721 | Grampound | u | Charles Cooke | Richard West | Death |
| 17 March 1721 | Truro | u* | John Selwyn | Thomas Wyndham | Resignation (Receiver General and Comptroller of Customs) |
| 18 March 1721 | Edinburgh | u* | Sir George Warrender | John Campbell | Death |
| 23 March 1721 | Tregony | u | James Craggs the Younger | Daniel Pulteney | Death |
| 24 March 1721 | Leominster | u | George Caswall | William Bateman | Expulsion |
| 1 April 1721 | Ripon | u* | John Aislabie | William Aislabie | Expulsion |
| 5 April 1721 | Rutland | u | Marquess of Granby | Sir Thomas Mackworth | Succeeded to a peerage |
| 10 April 1721 | King's Lynn | u* | Robert Walpole | Robert Walpole | First Lord of the Treasury and Chancellor of the Exchequer |
| 10 April 1721 | Seaford | u | Henry Pelham | Henry Pelham | Junior Lord of the Treasury |
| 12 April 1721 | Carlisle | c* | Thomas Stanwix | Henry Aglionby | Governor of Kingston-upon-Hull |
| 29 April 1721 | Bere Alston | c(*) | Edward Carteret | Philip Cavendish | Resignation (Joint-Postmaster General) |
| Philip Cavendish | St John Brodrick | By-election results reversed on petition 6 June 1721 |
| 1 May 1721 | Lostwithiel | u* | Galfridus Walpole | Marquess of Hartington | Resignation (Joint-Postmaster General) |
| 6 May 1721 | Salisbury | u* | Francis Swanton | Anthony Duncombe | Death |
| 11 May 1721 | Launceston | u* | Edward Herle | Alexander Pendarves | Death |
| 17 May 1721 | Oxfordshire | u* | James Herbert | Henry Perrot | Death |
| 25 May 1721 | Whitchurch | c(*) | Thomas Vernon | Frederick Tylney | Expulsion for attempting to influence a member of a committee on the South Sea Bubble |
| Frederick Tylney | John Conduitt | By-elections results reversed 26 June 1721 |
| 10 June 1721 | Flint Boroughs | u* | Sir John Conway | Thomas Eyton | Death |
| 12 June 1721 | Horsham | u* | Arthur Ingram | Charles Eversfield | Became a Scottish Peer |
| 20 July 1721 | Cockermouth | u | Lord Percy Seymour | Anthony Lowther | Death |
| 24 July 1721 | Surrey | u | Denzil Onslow | Sir William Scawen | Death |
| 2 August 1720 | Newport I.o.W. | u | Sir Tristram Dillington | Thomas Stanwix | Death |
| 30 August 1721 | Breconshire | u* | Edward Williams | William Gwyn Vaughan | Death |
| 2 September 1721 | Ayr Burghs | u | Thomas Kennedy | Duncan Forbes | Resignation (Baron of the Scottish Exchequer) |
| 25 October 1721 | Tewkesbury | c* | Nicholas Lechmere | The Viscount Gage | Elevated to the peerage |
| 27 October 1721 | New Woodstock | u | Sir Thomas Wheate | Charles Crisp Clayton | Death |
| 31 October 1721 | Plymouth | u | Sir George Byng | Pattee Byng | Elevated to the peerage |
| 1 November 1721 | St Ives | c* | Sir John Hobart | Sir John Hobart | Lord of Trade |
| 6 November 1721 | Midhurst | u | William Woodward Knight | Sir Richard Mill | Death |
| 7 November 1721 | Hedon | u* | Hugh Cholmley | Daniel Pulteney | Resignation (Victualling Commissioner) |
| 7 November 1721 | Tregony | u* | Daniel Pulteney | John Merrill | Lord of the Admiralty |
| 22 November 1721 | Barnstaple | u* | John Basset | Sir Hugh Acland | Death |
| 18 December 1721 | Minehead | c(*) | James Milner | Sir Richard Lane | Death |
| Sir Richard Lane | Robert Mansel | By-election results reversed on petition 9 January 1722 |
| 29 December 1721 | Orford | c | Sir Edward Turnor | Sir Edward Duke | Death |
| 5 January 1722 | Haddington Burghs | u* | Sir David Dalrymple | Sir James Dalrymple | Death |
| 8 February 1722 | Chipping Wycombe | u | Sir John Wittewrong | John Neale | Death |