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The design of experiments (DOE or DOX), also known as experiment design or experimental design, is the design of any task that aims to describe and explain the variation of information under conditions that are hypothesized to reflect the variation. The term is generally associated with experiments in which the design introduces conditions that directly affect the variation, but may also refer to the design of quasi-experiments, in which natural conditions that influence the variation are selected for observation.
In its simplest form, an experiment aims at predicting the outcome by introducing a change of the preconditions, which is represented by one or more independent variables, also referred to as "input variables" or "predictor variables." The change in one or more independent variables is generally hypothesized to result in a change in one or more dependent variables, also referred to as "output variables" or "response variables." The experimental design may also identify control variables that must be held constant to prevent external factors from affecting the results. Experimental design involves not only the selection of suitable independent, dependent, and control variables, but planning the delivery of the experiment under statistically optimal conditions given the constraints of available resources. There are multiple approaches for determining the set of design points (unique combinations of the settings of the independent variables) to be used in the experiment.
Main concerns in experimental design include the establishment of validity, reliability, and replicability. For example, these concerns can be partially addressed by carefully choosing the independent variable, reducing the risk of measurement error, and ensuring that the documentation of the method is sufficiently detailed. Related concerns include achieving appropriate levels of statistical power and sensitivity.
Correctly designed experiments advance knowledge in the natural and social sciences and engineering, with design of experiments methodology recognised as a key tool in the successful implementation of a Quality by Design (QbD) framework. [1] Other applications include marketing and policy making. The study of the design of experiments is an important topic in metascience.
A theory of statistical inference was developed by Charles S. Peirce in "Illustrations of the Logic of Science" (1877–1878) [2] and "A Theory of Probable Inference" (1883), [3] two publications that emphasized the importance of randomization-based inference in statistics. [4]
Charles S. Peirce randomly assigned volunteers to a blinded, repeated-measures design to evaluate their ability to discriminate weights. [5] [6] [7] [8] Peirce's experiment inspired other researchers in psychology and education, which developed a research tradition of randomized experiments in laboratories and specialized textbooks in the 1800s. [5] [6] [7] [8]
Charles S. Peirce also contributed the first English-language publication on an optimal design for regression models in 1876. [9] A pioneering optimal design for polynomial regression was suggested by Gergonne in 1815. In 1918, Kirstine Smith published optimal designs for polynomials of degree six (and less). [10] [11]
The use of a sequence of experiments, where the design of each may depend on the results of previous experiments, including the possible decision to stop experimenting, is within the scope of sequential analysis, a field that was pioneered [12] by Abraham Wald in the context of sequential tests of statistical hypotheses. [13] Herman Chernoff wrote an overview of optimal sequential designs, [14] while adaptive designs have been surveyed by S. Zacks. [15] One specific type of sequential design is the "two-armed bandit", generalized to the multi-armed bandit, on which early work was done by Herbert Robbins in 1952. [16]
A methodology for designing experiments was proposed by Ronald Fisher, in his innovative books: The Arrangement of Field Experiments (1926) and The Design of Experiments (1935). Much of his pioneering work dealt with agricultural applications of statistical methods. As a mundane example, he described how to test the lady tasting tea hypothesis, that a certain lady could distinguish by flavour alone whether the milk or the tea was first placed in the cup. These methods have been broadly adapted in biological, psychological, and agricultural research. [17]
This example of design experiments is attributed to Harold Hotelling, building on examples from Frank Yates. [21] [22] [14] The experiments designed in this example involve combinatorial designs. [23]
Weights of eight objects are measured using a pan balance and set of standard weights. Each weighing measures the weight difference between objects in the left pan and any objects in the right pan by adding calibrated weights to the lighter pan until the balance is in equilibrium. Each measurement has a random error. The average error is zero; the standard deviations of the probability distribution of the errors is the same number σ on different weighings; errors on different weighings are independent. Denote the true weights by
We consider two different experiments:
The question of design of experiments is: which experiment is better?
The variance of the estimate X1 of θ1 is σ2 if we use the first experiment. But if we use the second experiment, the variance of the estimate given above is σ2/8. Thus the second experiment gives us 8 times as much precision for the estimate of a single item, and estimates all items simultaneously, with the same precision. What the second experiment achieves with eight would require 64 weighings if the items are weighed separately. However, note that the estimates for the items obtained in the second experiment have errors that correlate with each other.
Many problems of the design of experiments involve combinatorial designs, as in this example and others. [23]
False positive conclusions, often resulting from the pressure to publish or the author's own confirmation bias, are an inherent hazard in many fields. [24]
Use of double-blind designs can prevent biases potentially leading to false positives in the data collection phase. When a double-blind design is used, participants are randomly assigned to experimental groups but the researcher is unaware of what participants belong to which group. Therefore, the researcher can not affect the participants' response to the intervention. [25]
Experimental designs with undisclosed degrees of freedom [ jargon ] are a problem, [26] in that they can lead to conscious or unconscious "p-hacking": trying multiple things until you get the desired result. It typically involves the manipulation – perhaps unconsciously – of the process of statistical analysis and the degrees of freedom until they return a figure below the p<.05 level of statistical significance. [27] [28]
P-hacking can be prevented by preregistering researches, in which researchers have to send their data analysis plan to the journal they wish to publish their paper in before they even start their data collection, so no data manipulation is possible. [29] [30]
Another way to prevent this is taking a double-blind design to the data-analysis phase, making the study triple-blind, where the data are sent to a data-analyst unrelated to the research who scrambles up the data so there is no way to know which participants belong to before they are potentially taken away as outliers. [25]
Clear and complete documentation of the experimental methodology is also important in order to support replication of results. [31]
An experimental design or randomized clinical trial requires careful consideration of several factors before actually doing the experiment. [32] An experimental design is the laying out of a detailed experimental plan in advance of doing the experiment. Some of the following topics have already been discussed in the principles of experimental design section:
The independent variable of a study often has many levels or different groups. In a true experiment, researchers can have an experimental group, which is where their intervention testing the hypothesis is implemented, and a control group, which has all the same element as the experimental group, without the interventional element. Thus, when everything else except for one intervention is held constant, researchers can certify with some certainty that this one element is what caused the observed change. In some instances, having a control group is not ethical. This is sometimes solved using two different experimental groups. In some cases, independent variables cannot be manipulated, for example when testing the difference between two groups who have a different disease, or testing the difference between genders (obviously variables that would be hard or unethical to assign participants to). In these cases, a quasi-experimental design may be used.
In the pure experimental design, the independent (predictor) variable is manipulated by the researcher – that is – every participant of the research is chosen randomly from the population, and each participant chosen is assigned randomly to conditions of the independent variable. Only when this is done is it possible to certify with high probability that the reason for the differences in the outcome variables are caused by the different conditions. Therefore, researchers should choose the experimental design over other design types whenever possible. However, the nature of the independent variable does not always allow for manipulation. In those cases, researchers must be aware of not certifying about causal attribution when their design doesn't allow for it. For example, in observational designs, participants are not assigned randomly to conditions, and so if there are differences found in outcome variables between conditions, it is likely that there is something other than the differences between the conditions that causes the differences in outcomes, that is – a third variable. The same goes for studies with correlational design (Adér & Mellenbergh, 2008).
It is best that a process be in reasonable statistical control prior to conducting designed experiments. When this is not possible, proper blocking, replication, and randomization allow for the careful conduct of designed experiments. [33] To control for nuisance variables, researchers institute control checks as additional measures. Investigators should ensure that uncontrolled influences (e.g., source credibility perception) do not skew the findings of the study. A manipulation check is one example of a control check. Manipulation checks allow investigators to isolate the chief variables to strengthen support that these variables are operating as planned.
One of the most important requirements of experimental research designs is the necessity of eliminating the effects of spurious, intervening, and antecedent variables. In the most basic model, cause (X) leads to effect (Y). But there could be a third variable (Z) that influences (Y), and X might not be the true cause at all. Z is said to be a spurious variable and must be controlled for. The same is true for intervening variables (a variable in between the supposed cause (X) and the effect (Y)), and anteceding variables (a variable prior to the supposed cause (X) that is the true cause). When a third variable is involved and has not been controlled for, the relation is said to be a zero order relationship. In most practical applications of experimental research designs there are several causes (X1, X2, X3). In most designs, only one of these causes is manipulated at a time.
Some efficient designs for estimating several main effects were found independently and in near succession by Raj Chandra Bose and K. Kishen in 1940 at the Indian Statistical Institute, but remained little known until the Plackett–Burman designs were published in Biometrika in 1946. About the same time, C. R. Rao introduced the concepts of orthogonal arrays as experimental designs. This concept played a central role in the development of Taguchi methods by Genichi Taguchi, which took place during his visit to Indian Statistical Institute in early 1950s. His methods were successfully applied and adopted by Japanese and Indian industries and subsequently were also embraced by US industry albeit with some reservations.
In 1950, Gertrude Mary Cox and William Gemmell Cochran published the book Experimental Designs, which became the major reference work on the design of experiments for statisticians for years afterwards.
Developments of the theory of linear models have encompassed and surpassed the cases that concerned early writers. Today, the theory rests on advanced topics in linear algebra, algebra and combinatorics.
As with other branches of statistics, experimental design is pursued using both frequentist and Bayesian approaches: In evaluating statistical procedures like experimental designs, frequentist statistics studies the sampling distribution while Bayesian statistics updates a probability distribution on the parameter space.
Some important contributors to the field of experimental designs are C. S. Peirce, R. A. Fisher, F. Yates, R. C. Bose, A. C. Atkinson, R. A. Bailey, D. R. Cox, G. E. P. Box, W. G. Cochran, W. T. Federer, V. V. Fedorov, A. S. Hedayat, J. Kiefer, O. Kempthorne, J. A. Nelder, Andrej Pázman, Friedrich Pukelsheim, D. Raghavarao, C. R. Rao, Shrikhande S. S., J. N. Srivastava, William J. Studden, G. Taguchi and H. P. Wynn. [34]
The textbooks of D. Montgomery, R. Myers, and G. Box/W. Hunter/J.S. Hunter have reached generations of students and practitioners. [35] [36] [37] [38] [39]
Some discussion of experimental design in the context of system identification (model building for static or dynamic models) is given in [40] and. [41]
Laws and ethical considerations preclude some carefully designed experiments with human subjects. Legal constraints are dependent on jurisdiction. Constraints may involve institutional review boards, informed consent and confidentiality affecting both clinical (medical) trials and behavioral and social science experiments. [42] In the field of toxicology, for example, experimentation is performed on laboratory animals with the goal of defining safe exposure limits for humans. [43] Balancing the constraints are views from the medical field. [44] Regarding the randomization of patients, "... if no one knows which therapy is better, there is no ethical imperative to use one therapy or another." (p 380) Regarding experimental design, "...it is clearly not ethical to place subjects at risk to collect data in a poorly designed study when this situation can be easily avoided...". (p 393)
In statistics, maximum likelihood estimation (MLE) is a method of estimating the parameters of an assumed probability distribution, given some observed data. This is achieved by maximizing a likelihood function so that, under the assumed statistical model, the observed data is most probable. The point in the parameter space that maximizes the likelihood function is called the maximum likelihood estimate. The logic of maximum likelihood is both intuitive and flexible, and as such the method has become a dominant means of statistical inference.
In vector calculus, the Jacobian matrix of a vector-valued function of several variables is the matrix of all its first-order partial derivatives. When this matrix is square, that is, when the function takes the same number of variables as input as the number of vector components of its output, its determinant is referred to as the Jacobian determinant. Both the matrix and the determinant are often referred to simply as the Jacobian in literature.
Experimental psychology refers to work done by those who apply experimental methods to psychological study and the underlying processes. Experimental psychologists employ human participants and animal subjects to study a great many topics, including sensation, perception, memory, cognition, learning, motivation, emotion; developmental processes, social psychology, and the neural substrates of all of these.
In the statistical theory of the design of experiments, blocking is the arranging of experimental units that are similar to one another in groups (blocks) based on one or more variables. These variables are chosen carefully to minimize the impact of their variability on the observed outcomes. There are different ways that blocking can be implemented, resulting in different confounding effects. However, the different methods share the same purpose: to control variability introduced by specific factors that could influence the outcome of an experiment. The roots of blocking originated from the statistician, Ronald Fisher, following his development of ANOVA.
This is a table of orthonormalized spherical harmonics that employ the Condon-Shortley phase up to degree . Some of these formulas are expressed in terms of the Cartesian expansion of the spherical harmonics into polynomials in x, y, z, and r. For purposes of this table, it is useful to express the usual spherical to Cartesian transformations that relate these Cartesian components to and as
Random assignment or random placement is an experimental technique for assigning human participants or animal subjects to different groups in an experiment using randomization, such as by a chance procedure or a random number generator. This ensures that each participant or subject has an equal chance of being placed in any group. Random assignment of participants helps to ensure that any differences between and within the groups are not systematic at the outset of the experiment. Thus, any differences between groups recorded at the end of the experiment can be more confidently attributed to the experimental procedures or treatment.
The GOST hash function, defined in the standards GOST R 34.11-94 and GOST 34.311-95 is a 256-bit cryptographic hash function. It was initially defined in the Russian national standard GOST R 34.11-94 Information Technology – Cryptographic Information Security – Hash Function. The equivalent standard used by other member-states of the CIS is GOST 34.311-95.
Bootstrapping is any test or metric that uses random sampling with replacement, and falls under the broader class of resampling methods. Bootstrapping assigns measures of accuracy to sample estimates. This technique allows estimation of the sampling distribution of almost any statistic using random sampling methods.
The interaction information is a generalization of the mutual information for more than two variables.
In the design of experiments and analysis of variance, a main effect is the effect of an independent variable on a dependent variable averaged across the levels of any other independent variables. The term is frequently used in the context of factorial designs and regression models to distinguish main effects from interaction effects.
The Y class is a class of diesel locomotives built by the Tasmanian Government Railways between 1961 and 1971.
In Euclidean geometry, the intersection of a line and a line can be the empty set, a point, or another line. Distinguishing these cases and finding the intersection have uses, for example, in computer graphics, motion planning, and collision detection.
The average treatment effect (ATE) is a measure used to compare treatments in randomized experiments, evaluation of policy interventions, and medical trials. The ATE measures the difference in mean (average) outcomes between units assigned to the treatment and units assigned to the control. In a randomized trial, the average treatment effect can be estimated from a sample using a comparison in mean outcomes for treated and untreated units. However, the ATE is generally understood as a causal parameter that a researcher desires to know, defined without reference to the study design or estimation procedure. Both observational studies and experimental study designs with random assignment may enable one to estimate an ATE in a variety of ways.
In the design of experiments, completely randomized designs are for studying the effects of one primary factor without the need to take other nuisance variables into account. This article describes completely randomized designs that have one primary factor. The experiment compares the values of a response variable based on the different levels of that primary factor. For completely randomized designs, the levels of the primary factor are randomly assigned to the experimental units.
Lu AA-33810 is a drug developed by Lundbeck, which acts as a potent and highly selective antagonist for the Neuropeptide Y receptor Y5, with a Ki of 1.5nM and around 3300x selectivity over the related Y1, Y2 and Y4 receptors. In animal studies it produced anorectic, antidepressant and anxiolytic effects, and further research is now being conducted into its possible medical application in the treatment of eating disorders.
The Mandelbulb is a three-dimensional fractal, constructed for the first time in 1997 by Jules Ruis and in 2009 further developed by Daniel White and Paul Nylander using spherical coordinates.
Y Records was a British independent record label set up in 1980 by Dick O'Dell in the United Kingdom, and distributed by Rough Trade.
The Silverton Tramway Y class was a class of 2-6-0 and 2-6-2T steam locomotives of the Silverton Tramway Company, operating between Broken Hill, New South Wales, and the border of South Australia.
In computer science, merge-insertion sort or the Ford–Johnson algorithm is a comparison sorting algorithm published in 1959 by L. R. Ford Jr. and Selmer M. Johnson. It uses fewer comparisons in the worst case than the best previously known algorithms, binary insertion sort and merge sort, and for 20 years it was the sorting algorithm with the fewest known comparisons. Although not of practical significance, it remains of theoretical interest in connection with the problem of sorting with a minimum number of comparisons. The same algorithm may have also been independently discovered by Stanisław Trybuła and Czen Ping.
The Georgia Avenue–Maryland Line, designated Route Y2, Y7, Y8, is a daily bus route operated by the Washington Metropolitan Area Transit Authority between Silver Spring station of the Red Line of the Washington Metro and MedStar Montgomery Medical Center in Olney or the Georgia Ave – ICC Park & Ride Lot (Y7). The line operates every 20 minutes during the weekday peak hour and weekend late nights, 30 minutes all other times on weekdays, and 40–45 minutes on weekends. Y2 trips are roughly 55 minutes long, Y7 trips are roughly 62 minutes long, and Y8 trips are roughly 70 minutes long. This route provides service along Georgia Avenue in Maryland providing service to multiple communities.
Indeed, Pierce's work contains one of the earliest explicit endorsements of mathematical randomization as a basis for inference of which I am aware (Peirce, 1957, pages 216–219
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