| Airline | State or territory | Image | IATA | ICAO | Callsign | Hubs and focus cities | Founded | Ceased operations | Notes |
|---|
| N |
| NAA North American Airlines | California | | | | | Hollywood Burbank | 1954 | 1957 | [1] |
| Nantucket Airlines | Massachusetts | | | ACK | ACK AIR | Hyannis | 1986 | 1989 | Merged with Cape Air [2] |
| Nantucket Shuttle | Massachusetts | | | | | Hyannis | 2006 | 2011 | Founded as Horizon Air Charter. Acquired by Island Airlines [3] |
| Napier Air Service | Alabama | | | NAP | NAPIER | Dothan | 1948 | 1991 | [4] |
| Naples Airlines | Florida | | | | | Naples | 1960 | 1980 | Merged into Provincetown-Boston Airlines [5] |
| Nashville Eagle | Tennessee | | | | | Nashville | 1987 | 1991 | Acquired AVAir. Merged with Command Airways to become Flagship Airlines [6] |
| National Air Transport | Illinois | | | | | Chicago Midway | 1925 | 1934 | |
| National Airlines (1934–1980) | Florida | | NA | NA | NATIONAL | Miami | 1934 | 1980 | Merged into Pan American World Airways |
| National Airlines (1983) | | | (none) | OV (NAN) | NATION AIR | | 1983 | 1986 | |
| National Airlines (1999–2002) | Nevada | | N7 | ROK | RED ROCK | Las Vegas McCarran | 1999 | 2002 | |
| National Airlines / Private Jet Expeditions | Kansas | | 5J | PJE | Pee Jay | Atlanta | 1994 | 1995 | |
| National Airways | Massachusetts | | | | | Boston | 1931 | 1940 | Founded by Paul Collins, Sam Solomon, Amelia Earhart. Operated 2 Stinson Airliner. To Delta Air Lines [7] |
| National Commuter Airlines | Florida | | | | | Miami | 1982 | 1984 | Acquired by Air Florida |
| National Executive Flight Service | Massachusetts | | | | | Boston | 1960 | 1967 | Renamed to Executive Airlines [8] |
| National Florida Airlines | Florida | | | NFA | VOYAGER | Daytona Beach | 1981 | 1983 | |
| National Freight Service | California | | | | | Los Angeles | 1945 | 1949 | Renamed to Flying Tigers Airlines. Operated Budd Conestoga, C-46 [9] |
| National Parks Airways | Idaho | | | | | Salt Lake City | 1927 | 1937 | Bought by Western Airlines |
| National Skyway Freight Corporation | California | | | | | Los Angeles | 1945 | 1946 | Operated Budd Conestoga. Renamed to Flying Tiger Line [10] |
| Nations Air | Pennsylvania | | N5 | NAE | NATIONS EXPRESS | Pittsburgh | 1995 | 1998 | |
| Nationwide Air Transport Service | Florida | | | | | Miami | 1946 | 1951 | Cargo carrier [11] |
| Nationwide Airlines | Michigan | | | | | Detroit | 1947 | 1952 | Air mail and passenger service [12] |
| Nationwide Airlines Southeast | Georgia | | | | | Atlanta | 1969 | 1978 | Name changed to Air South (Georgia) |
| Navajo Airlines | Arizona | | | | | Winslow | 1930 | n/a | Operated Kreutzer Air Coach [13] |
| Nenana Fuel Company | Alaska | | | | | Fairbanks | 1958 | 1992 | Cargo carrier. Operated C-46, DC-3 [14] |
| Nevada Airlines | California | | | | | Los Angeles Grand Central | 1929 | 1929 | Operated four Lockheed Vega [13] |
| Nevada Airlines | Nevada | | | | | | 1963 | 1962 | Established as Blatz Airlines. Succeeded by Hawthorne-Nevada Airlines in 1964 [15] |
| New England Air Express | New Jersey | | | NEZ | ENGAIR | Teterboro | 1949 | 1954 | Acquired by Flying Tiger Line [16] |
| New England Air Transport | Maine | | | | | | 2008 | 2009 | |
| New England Central Airways | Massachusetts | | | | | Boston | 1946 | 1947 | Operated Cessna Bobcat [17] |
| New England Commuter | New Hampshire | | | | | Manchester–Boston | 1971 | 1971 | Operated Cessna 402 [18] |
| New England & Western Air Transportation Co. | Massachusetts | | | | | Westfield-Barnes | 1930 | 1930 | |
| New Haven Airways | Connecticut | | | | HAVEN AIR | Tweed New Haven | 1978 | 1980 | Renamed to NewAir [19] |
| New Jersey Airways | | | | | | | 1977 | 1980 | Merged into Merrimack Airlines [20] |
| New Mexico Airlines | Arizona | | LW | NMI | TSUNAMI | Albuquerque | 2007 | 2015 | A Pacific Wings subsidiary |
| New Orleans Air Lines | Louisiana | | | | | New Orleans Lakefront | 1931 | 1931 | [13] |
| New York & Western Airlines | New York | | | | | Newark Liberty | 1931 | n/a | Subsidiary of Pittsburgh Airlines [13] |
| New York Air | New York | | NY | NYA | APPLE | New York-LaGuardia | 1980 | 1987 | To Continental Airlines |
| New York Air Connection | | 1985 | Routes feeding New York Air [21] |
| New York Airways | New York | | NY | NYA | NEW YORK | New York-LaGuardia | 1949 | 1979 | Helicopter services |
| New York Helicopter | New York | | HD | NYH | | East 34th Street Heliport | 1980 | 1988 | |
| New York Safety Airlines | New York | | | | | Roosevelt Field | 1929 | 1930 | Established as Tri-Motor Safety Airlines. Acquired by New York, Rio, and Buenos Aires Line [22] |
| New York-Newport Air Service | New York | | | | | Newark Liberty | 1922 | 1923 | [13] |
| New York, Philadelphia & Washington Airways | New York | | | | | Newark Liberty | 1929 | 1934 | Acquired by Eastern Air Transport [13] |
| New York, Rio, and Buenos Aires Line | New York | | | | | New York Curtiss | 1929 | 1930 | To Pan American World Airways |
| NewAir | Connecticut | | | | | Tweed New Haven | 1980 | 1990 | Established as New Haven Airways [23] |
| Niemeyer Aviation | Indiana | | | | | | 1972 | 1999 | Founded by Don Neimeyer. Operated Grumman AA-5 Tiger [24] |
| Noland-Decoto Flying Service | Washington | | | | | Yakima | 1966 | 1998 | Charter, aerial photography, ambulance service [25] |
| Nomads Travel Club | Michigan | | | | | Detroit Metro | 1965 | 2011 | Oldest travel club. Operated 727-200 [26] |
| Nome Flying Service | Alaska | | | | | Nome | 1971 | 1979 | [27] |
| North American Airlines | California | | | | | Los Angeles | 1950 | 1956 | Part of North American Aircoach System. Operated C-46, DC-3, DC-4, DC-6 [28] |
| North American Airlines | Florida | | | | | Miami | 1980 | 1982 | Established as Air Miami. Operated CASA 212 [29] |
| North American Airlines | Georgia | | NA | NAO | NORTH AMERICAN | Tampa | 1989 | 2014 | Went bankrupt |
| North American Airways | Wisconsin | | | | | Appleton | 1930s | 1930s | Operated Stinson Detroiter [13] |
| North Central Airlines | Minnesota | | NC | | NORTH CENTRAL | Chicago O'Hare | 1944 | 1979 | Merged with Southern Airways to form Republic Airlines (1979-1986) |
| North Continent Airlines | California | | | | | Long Beach | 1983 | 1991 | Operated Hamilton Westwind III, Beech 1900, Twin Otter [30] |
| North Pacific Airlines | Alaska | | | | | Anchorage | 1983 | 1992 | Founded by Roy Musgrove [31] |
| North Pacific Airlines | Washington | | | | | Seattle–Tacoma | 1987 | 1991 | Merged with WestAir Commuter Airlines |
| North Slope Supply Company | Alaska | | | | | Anchorage | 1969 | 1969 | Went bankrupt [32] |
| North South Airways | Georgia | | SPK | | SPK | Statesboro | 1983 | 2003 | Founded as Diamond Aviation [33] |
| North Star Air Cargo | Alaska | | | SBX | SKY BOX | Anchorage | 1989 | 2008 | [34] |
| North Star Aircoach | New York | | | | | New York-LaGuardia | 1951 | 1952 | [35] |
| Northcoast Executive Airlines | Ohio | | 5N | NCE | TOP HAT | Dayton | 1990 | 1991 | |
| Northeast Airlines | Massachusetts | | NE | DOW | NORTHEAST | Boston | 1940 | 1972 | Founded 1931 as Boston-Maine Airways, merged into Delta Air Lines |
| Northeast Airlines | Maine | | | NEE | NORTHEAST | Portland Jetport | 1997 | 1999 | Began as Downeast Express [36] |
| Northeast Express Regional Airlines | New Hampshire | | 2V | NEE | | Manchester–Boston | 1974 | 1994 | Went bankrupt |
| Northeastern International Airways | Florida | | QS | QSA | NORTHEASTER | Fort Lauderdale-Hollywood | 1982 | 1986 | |
| Northern Air Service | Alaska | | | | | | 1930 | 1930 | [37] |
| Northern Air Transport | Alaska | | | | | | 1924 | 1926 | Renamed to Wien Airways of Alaska [38] |
| Northern Airlines | North Dakota | | | | | Minot | 1928 | 1929 | [13] |
| Northern Airlines | Ohio | | | | | St. Marys | 1968 | 1970 | Operated Beech 18, Twin Otter [39] |
| Northern Airlines | Minnesota | | | | | St. Paul Downtown | 1981 | 1982 | Filed for bankruptcy [40] |
| Northern Consolidated Airlines | Alaska | | | | | Anchorage | 1947 | 1968 | Merged into Wien Airways of Alaska. Operated DC-3, Short Skyvan |
| Northern Illinois Commuter Airlines | Illinois | | | NIC | ILLINOIS COMMUTER | | 1979 | 1980 | Operated Beech 99 [41] |
| Northern International Airlines | New York | | | | | New York Kennedy | 1954 | 1966 | Renamed to Direct Airlines [42] |
| Northern Star Airlines | Illinois | | UO | XAP | MID TOWN | Chicago Gary | 1994 | 1995 | Reorganized as Northern Star Airlines [43] |
| Northwest Airlines | Minnesota | | NW | NWA | NORTHWEST | Minneapolis–Saint Paul | 1934 | 2010 | Formed 1926 as Northwest Airways, merged into Delta Air Lines |
| Northwest Orient Airlines | | | | Renamed to Northwest Airlines |
| Northwest Airlink | | | NWX | FLAG SHIP | 1984 | 2009 | |
| Northwest Sky Ferry | Washington | | | | | Friday Harbor | 2007 | 2014 | Established as Rugby Aviation in 1999. Merged into San Juan Airlines [44] |
| O |
| Oahu & Kauai Airlines | Hawaii | | | | | Honolulu | 1976 | 1976 | Operated Cessna 402 [45] |
| Oak Harbor Airlines | Washington | | | | | Oak Harbor | 1971 | 1974 | Renamed to Harbor Airlines [46] |
| Ocean Airways | Florida | | | | | | 1980 | 1980 | [47] |
| Ocean Reef Airways | Florida | | | | | Key Largo | 1970 | 1982 | Merged into Provincetown-Boston Airlines [48] |
| Ocean Wings | Massachusetts | | | TUK | TUCKERNUCK | Nantucket | 1990 | 2002 | To Island Airlines [49] |
| Oceanair | Puerto Rico | | | TJ | | | 1970s | 1980s | To Trans Commuter Airline |
| Odyssey Transport | Nevada | | | | | Las Vegas McCarran | 1998 | 2002 | Cargo operator [50] |
| Okair (Oaha and Kauai Airlines) | Hawaii | | YQ | | | Honolulu | 1975 | 1980 | [13] |
| Oklahoma Short Line Airways | Oklahoma | | | | | Tulsa | 1930 | 1931 | Founded by L H Atkinson. Operated Ryan Brougham [13] |
| Oklahoma-Texas Air Line | Oklahoma | | | | | Oklahoma City | 1929 | 1932 | [13] |
| Olson Air Service | Alaska | | 4B | | | Nome | 1987 | 2006 | [51] |
| Omaha Aviation Commuter | Nebraska | | | | | Omaha | 1979 | 1980 | [52] |
| Omega Air Cargo | Florida | | | | | Fort Lauderdale–Hollywood | 2004 | 2004 | Renamed to Focus Air Cargo [53] |
| Omni Air Express | Oklahoma | | | | OMNI-EXPRESS | Tulsa | 1993 | 1997 | Renamed Omni Air International [54] |
| Omni Airlines | Arizona | | OE | | | Flagstaff Pulliam | 1977 | 1981 | Renamed to Arizona Pacific Airlines [55] |
| Omniflight Helicopters | Texas | | | | | Addison | 1962 | 2011 | Acquired by Air Methods [56] |
| ONAT (Orvis Nelson Air Transport Company) | California | | OE | | | Oakland | 1946 | 1946 | Renamed to Transocean Air Lines [57] |
| Oneida County Aviation | New York | | | | | Oneida County | 1975 | 1976 | Renamed to Empire Airlines [58] |
| OneJet | Pennsylvania | | J1 | | | Pittsburgh | 2015 | 2018 | Established as PrimAir [59] |
| ONG Airlines | Illinois | | | | | Chicago Meigs Field | 2015 | 2018 | Founded by William Armitage Ong. Established as PrimAir [60] |
| Orange Air | Florida | | U3 | ORN | ORANGE JET | Orlando Sanford | 2011 | 2017 | Charter operator [61] |
| Orion Air | North Carolina | | HS | TAG | TAGGE | Raleigh–Durham | 1980 | 1989 | Sold to Ryan International [62] |
| Orion Airways | Missouri | | | | | St. Louis Lambert | 1971 | 1971 | Third-level services [63] |
| Orlando Airlines | Florida | | | | | Orlando | 1943 | 1947 | Renamed to Florida Airways [64] |
| Oscar Winchell Air Service | Alaska | | | | | Anchorage | 1931 | 1932 | Founded by Oscar Winchell [65] |
| Otis Spunkmeyer Air | California | | | | | Oakland | 1990 | 1999 | Established as Sentimental Journeys Aviation. Operated DC-3 [66] |
| Otter Air | Washington | | | | | Seattle Lake Union Seaplane Base | 1985 | 1986 | Scheduled and charter seaplane services. Acquired by Kenmore Air [67] |
| Overland Airways | Oklahoma | | | | | Alameda | 1929 | 1932 | [13] |
| Overseas International Distributors | California | | | | | Van Nuys | 1978 | 1979 | Renamed to Ginny Aviation. Operated Boeing 720 [68] |
| Overseas National Airways | New York | | OV | ONA | ONAIR | New York Kennedy | 1950 | 1978 | |
| Owensboro Aviation | Kentucky | | | | | Owensboro–Daviess | 1964 | 1974 | Founded by L.S. Cox. Renamed to Air Kentucky [69] |
| Oxnard Air Freight | California | | | | | Oxnard | 1950 | 1951 | Founded by Ross Hart and Jack Lewin. Merged into Standard Airlines. Operated DC-4 [70] |
| Ozark Air Lines | Missouri | | OZ | OZA | OZARK | Springfield–Branson | 1950 | 1986 | To Trans World Airlines |
| Ozark Air Lines (1998) | Missouri | | | OZR | | Oklahoma Will Rogers | 1998 | 2001 | To Great Plains Airlines |
| P & M Flying Services | Maine | | | PAZ | PAPA MIKE | Presque Isle | 1965 | 1968 | Founded by John C. Philbrick. Renamed to Aroostook Airways [71] |
| P & N Flight and Charter | Indiana | | | | | Marion | 1995 | 1996 | Passenger and cargo charters [72] |
| P |
| PAC Air | Massachusetts | | | PCR | PACAIR | Provincetown | 1989 | 1989 | Owned by Arthur Pearson. Sold to San Juan Airlines [73] |
| Pace Airlines | North Carolina | | Y5 | PCE | PACE | Winston-Salem Smith Reynolds | 1996 | 2002 | To Hooters Air |
| Pacific Air Charter | California | | | PRC | PACIFIC CHARTER | San Diego | 1994 | 1996 | Acquired by Airnet Express [74] |
| Pacific Air Express | Hawaii | | | PCF | PACIFIC EXPRESS | Honolulu | 1983 | 1986 | [75] |
| Pacific Air Freight | Washington | | | | | Seattle–Tacoma | 1951 | 1968 | Merged with Airborne of California to form Airbourne Freight Company [76] |
| Pacific Air Lines | California | | PC | PC | PACIFIC | San Francisco | 1946 | 1968 | Formerly Southwest Airways, renamed 1958, merged with Bonanza Air Lines and West Coast Airlines to form Air West which was then renamed Hughes Airwest |
| Pacific Air Transport | California | | | | | | 1926 | 1928 | Merged into Boeing Air Transport, but remained a separate division |
| Pacific Airways | Alaska | | 3F | | | Ketchikan | 2000 | 2020 | Operated DHC Beaver floatplane [77] |
| Pacific Alaska Airlines | Alaska | | AW | PAK | PACIFIC ALASKA | Fairbanks | 1972 | 1986 | Operated de Havilland Heron, DC-3, DC-6, Fairchild Packet, B-25 Mitchell [78] |
| Pacific Alaska Airways | Alaska | | | | | Juneau | 1932 | 1941 | Merged into Pan American World Airways |
| Pacific American Airlines | California | | | | | Burbank Hollywood | 1976 | 1979 | |
| Pacific Cal Air | California | | AX | PCC | | Oakland | 1979 | 1984 | [79] |
| Pacific Cargo | California | | | | | Los Angeles | 1985 | 1985 | Operated DC-8-50F [80] |
| Pacific Coast Airlines | | | | | SONIC | Santa Barbara | 1981 | 1985 | Established as Apollo Airways [81] |
| Pacific Corporation | Delaware | | | | | | 1950 | 1979 | Holding company Used by CIA to control aviation front organizations |
| Pacific East Airlines | California | | 6P | PCE | | Los Angeles | 1983 | 1984 | |
| Pacific Express | California | | VB | WCA | | Chico | 1982 | 1984 | |
| Pacific Inter Air | Florida | | QT | PIA | | Miami | 1985 | 1987 | Established as Pacific Interstate. Renamed to Bahamas Express [82] |
| Pacific International Airlines | Arizona | | | PIN | | Tucson | 1995 | 1996 | Established as Sportsflight Airways [83] |
| Pacific Interstate Airlines | Nevada | | | | | Las Vegas McCarran | 1984 | 1985 | Renamed Pacific Inter Air [84] |
| Pacific Island Aviation | Northern Mariana Islands | | 9J | PSA | PACIFIC ISLE | Saipan | 1988 | 2005 | |
| Pacific Marine Airways | California | | | | | Avalon | 1922 | 1928 | Operated two Curtiss HS [13] |
| Pacific National Airways | California | | | | | Burbank | 1980 | 1981 | Established as Air Tours [85] |
| Pacific Northern Airlines | Alaska | | PN | | | Anchorage | 1947 | 1967 | Established as Woodley Airways by Art Woodley in 1932. Renamed to Pacific Northern Airway. Merged into Western Airlines [86] |
| Pacific Ocean Airlines | Hawaii | | | | | Honolulu | 1946 | 1948 | [87] |
| Pacific Overseas Airlines | California | | | | | Ontario | 1946 | 1947 | Established as Industrial Air Transport. Operated C-54 Skymaster. Daily flight to Tokyo [88] |
| Pacific Seaboard Air Lines | California | | | | | Monterey | 1933 | 1935 | Renamed to Chicago and Southern Air Lines. Operated Bellanca CH-300 [13] |
| Pacific Skyway | California | | | | | | 2000 | 2003 | |
| Pacific Southwest Airlines | California | | PS | PSX | SMILEY | Los Angeles | 1949 | 1988 | To US Airways |
| Pacific Western Airways | Utah | | | | | Salt Lake City | 1968 | 1969 | [89] |
| Pacific Wings | Arizona | | LW | NMI | TSUNAMI | Albuquerque Sunport | 1974 | 2015 | See also New Mexico Airlines, Georgia Skies, TennesseeSkies, and KentuckySkies |
| Paklook Air | Alaska | | | | | Fairbanks | 2003 | 2003 | Fouded by Howard Holman and Terry Cratty. Renamed to Servant Air. Operated Cessna 207 [90] |
| Palm Springs Airlines | California | | | | | Palm Springs | 1936 | 1937 | [91] |
| Pan Alaska Airways | Alaska | | | | | Fairbanks | 1970 | 1973 | Renamed to Pacific Alaska Airlines. Acquired by Empire Airlines in 1989 [92] |
| Pan Am Air Bridge | Florida | | | | | Miami Seaplane Base | 1996 | 1999 | [93] |
| Pan American World Airways | New York | | PA | PAA | CLIPPER | New York Kennedy | 1927 | 1991 | Went bankrupt |
| Pan Am Cargo | 1963 | 1983 | Subsidiary of Pan American World Airways |
| Pan Am Express | | RZ | PXX | PAN AM | Miami | 1981 | 1991 | A flight connection code sharing service operated by several air carriers. See also Ransome Airlines |
| Pan Am Shuttle | | | | | | 1986 | To Delta Shuttle |
| Pan American Airways (1996–1998) | Florida | | PN | PAA | CLIPPER | Miami | 1996 | 1998 | Merged with Carnival Air Lines |
| Pan American Airways (1998–2004) | New Hampshire | | PA | PAA | CLIPPER | Portsmouth | 1998 | 2004 | To Boston-Maine Airways |
| Pan American-Grace Airways | Florida | | PY | PY | | | 1929 | 1969 | To Braniff International Airways |
| Panagra Airways | Florida | | 7E | PGI | PANAGRA | Fort Lauderdale-Hollywood | 1996 | 1999 | [94] |
| Panama Airways | Florida | | | | | Panama City–Bay County | 1990 | 1991 | [95] |
| Panhandle Airways | Florida | | | | | | 1976 | 1978 | Operated Beech 18, DC-3 [96] |
| Paradise Airlines | California | | | | | Oakland | 1962 | 1964 | Operated Lockheed L-049 Constellation [97] |
| Paradise Airways | Virginia | | | | | Manassas | 1995 | 1997 | Charter carrier. Renamed to Prestige Airlines [98] |
| Paradise Island Airlines | Florida | | BK | PDI | PARADISE ISLAND | Miami | 1989 | 1999 | |
| Paragon Air | Hawaii | | | | | Honolulu | 1985 | 2006 | Charter operator [99] |
| Paramount Airlines | California | | | | | Burbank | 1960 | 1962 | Established as Paul Mantz Air Service. Non-scheduled transcontinental flights. Operated DC-7C Seven Seas [100] |
| Parks College Airline | Illinois | | | | | Curtiss-Steinberg | 1935 | 1950 | Acquired by Ozark Air Lines |
| Passaat Airlines | Florida | | | | | Miami | 1965 | 1967 | Charter operator [101] |
| Patriot Air | Texas | | | | | Dallas Love Field | 2001 | 2002 | [102] |
| Patriot Airlines | California | | P7 | PAA | PATRIOTAIR | San Jose | 1991 | 1994 | [103] |
| Paul Mantz Air Service | California | | | | | Burbank | 1959 | 1960 | Renamed to Paramount Airlines. Operated DC-7C Seven Seas, L-749 Constellation [104] |
| Peak Air | Colorado | | | | | Aspen | 1995 | 1995 | Renamed to Aspen Mountain Air [105] |
| Pearson Aircraft | Washington | | YE | | | Port Angeles | 1972 | 1981 | Founded by Earl Pearson. Acquired by San Juan Airlines [106] |
| Pearson-Alaska Airlines | Alaska | | | | | Anchorage | 1948 | 1956 | Founded by Eric Pearson. Renamed to World Wide Airlines. Operated DC-4, C-46, L-749, L-1049 [107] |
| Peck & Rice Airways | Alaska | | | | | Bethel | 1930 | 1939 | Founded by John Peck and Wyman Rice. Operated Travel Air 6000B [108] |
| Pegaso Air | California | | | | | Los Angeles | 1985 | 1986 | [109] |
| Pegasus Air | Washington | | | | | Bremerton | 1985 | 1986 | Operated Cessna 172 [110] |
| Peninsula Airways | California | | | | | San Carlos | 1973 | 1973 | [111] |
| Peninsular Air Transport | Florida | | | | | Miami | 1946 | 1955 | [112] |
| Pennsylvania Air Lines | Pennsylvania | | | | | Bettis Field | 1930 | 1936 | Merged with Central Airlines to form Pennsylvania Central Airlines [113] |
| Pennsylvania Airlines | Pennsylvania | | | | | Harrisburg | 1980 | 1985 | Acquired by USAir [114] |
| Pennsylvania Central Airlines | Pennsylvania | | | | | Allegheny County | 1936 | 1948 | Formed by the merger of Central Airlines and Pennsylvania Airlines. Operated DC-3A. To Capital Airlines |
| Pennsylvania Commuter Airlines | Pennsylvania | | AL | | | Harrisburg | 1970 | 1980 | Established as Harrisburg Commuter. Became an Allegheny Commuter and renamed to Pennsylvania Airlines. [115] |
| Penobscot Airways | Maine | | | | | Millinocket Seaplane Base | 1949 | 1955 | Founded by Arthur Harjula. Renamed to Stonington Flying Service [116] |
| People Express Airlines (1980s) | New Jersey | | PE | PEX | PEOPLE EXPRESS | Newark Liberty | 1981 | 1987 | Merged into Continental Airlines |
| People Express Airlines (2010s) | Virginia | | V2 | RBY | RUBY | Newport News/Williamsburg | 2014 | 2014 | |
| Permian Airways | Texas | | | | | Midland | 1979 | 1982 | Founded by John Andrews and David Glover [117] |
| Pet Airways | Florida | | | SUB | SUB AIR | | 2009 | 2013 | |
| PHH Air | Kansas | | | | | Wichita | 1986 | 1989 | Founded by Jack P DeBoer and Ron Ryan. Established as Ryan Aviation. Renamed to Ryan International Airlines [118] |
| Philadelphia Rapid Transit | Pennsylvania | | | | | Philadelphia | 1926 | 1926 | Operated Fokker F.VII [119] |
| Phoenix Air | Georgia | | | | | Cartersville | 2002 | 2003 | [120] |
| Phoenix Airways | Georgia | | | | | DeKalb–Peachtree | 1980 | 1981 | [121] |
| Pickwick Airways | California | | | | | Los Angeles | 1929 | 1930 | Operated Bach Air Yacht |
| Piedmont Airlines (1948–1989) | North Carolina | | PI | PAI | PIEDMONT | Charlotte Douglas | 1948 | 1989 | To US Airways |
| Pilgrim Airlines | Connecticut | | PM | PMT | PILGRIM | Groton-New London | 1960 | 1986 | Acquired by Business Express Airlines |
| Pine State Airlines | Maine | | PW | PXX | | Frenchville | 1990 | 1999 | Operated Cessna 402C [122] |
| Pinehurst Airlines | Georgia | | MQ | | | Whispering Pines | 1973 | 1982 | Operated YS-11, C-47A. Went into bankruptcy due to PATCO [123] |
| Pinnacle Airlines | Michigan | | 9E | FLG | FLAGSHIP | Detroit Metro | 2002 | 2013 | Establishes as Express Airlines I. Renamed to Endeavor Air [124] |
| Pioneer Air Lines | Texas | | | | | Houston-Hobby | 1946 | 1955 | Merged into Continental Airlines [125] |
| Pioneer Airlines | Colorado | | JB | PIO | PIONEER | Denver | 1976 | 1986 | Establishes as Pioneer Airways. Operated Beech 99 [126] |
| Pioneer Airways | South Dakota | | | | | | 1927 | 1928 | Founded by Oscar Winclell. Renamed to Rapid City Airlines. Operated Curtiss Jenny [127] |
| Pioneer Airways | Alaska | | | | | Ketchikan | 1931 | 1931 | Founded by Vern C. Gorst, Roy F. Jones, C.R. Wright Jones. Renamed to Ketchikan Airways. Operated Curtiss Jenny [128] |
| Pitcairn Aviation | New York | | | | | Floyd Bennett Field | 1927 | 1930 | Founded by Harold J. Pitcairn. Renamed to Eastern Air Transport [129] |
| Pittsburgh Airways | Pennsylvania | | | | | Allegheny County | 1929 | 1930 | Founded by James Condon, Ted Taney. Subsidiary of New York & Western Airlines [13] |
| Planet Airways | Florida | | | PLZ | PLANET | Orlando | 1995 | 2006 | Began as Airship Airways [130] |
| Platinum Airlines | Florida | | P2 | PLS | | Miami | 1998 | 2006 | |
| Pocono Airlines | Pennsylvania | | 4P | POC | POCONO | Wilkes-Barre/Scranton | 1965 | 1990 | Began flying as an Allegheny Commuter, switched to TWA Express in 1989. [131] |
| Polar Airways | Alaska | | PE | | | Anchorage | 1968 | 1979 | Operated Aero Commander |
| Pollack Flying Service | Alaska | | | | | Fairbanks | 1933 | 1942 | Founded by Frank Pollack. Sold to Alaska Star Airlines [132] |
| Pompano Airways | Florida | | MG | | | Fort Lauderdale Executive | 1983 | 1984 | Subcontract carrier for Air Florida Commuter [133] |
| Pomona Valley Aviation | California | | | | | Brackett Field | 1968 | 1975 | Renamed to Inland Empire Airlines. Operated Piper Navajo, Swearingen Metroliner [134] |
| Port Angeles Air Transport | Washington | | | | | Port Angeles | 1931 | 1931 | Operated Stinson Detroiter [13] |
| Potomac Air | Texas | | BK | PDC | DISTRICT | Washington National | 2001 | 2001 | Renamed to Midatlantic Airways. Operated DHC-8 [135] |
| Precision Airlines | New Hampshire | | RP | PRE | PRECISION | Manchester–Boston | 1972 | 1994 | Was an Eastern Express carrier. Acquired by Northeast Express in 1989. [136] |
| Premier Executive Transport Services | Massachusetts | | | | | | | | Alleged to be a front organization for the Central Intelligence Agency |
| President Airlines | California | | | | | Burbank | 1960 | 1962 | Operated DC-4, DC-6, DC-7 [137] |
| Presidential Air | California | | | PRD | PRESIDENTIAL | Long Beach | 1993 | 1996 | Operated Airbus A300 [138] |
| Presidential Airways (scheduled) | Virginia | | XV | | WASHINGTON EAGLE | Washington Dulles | 1985 | 1989 | |
| Presidential Express | Virginia | | CJ | CJC | COLGAN | Manassas | 1986 | 1989 | Began as Colgan Airways [139] |
| Prestige Airways | New York | | OJ | PAI | | New York Kennedy | 1995 | 1997 | Established as Paradise Airways in 1990. Operated 727-200 [140] |
| Pride Air | Louisiana | | NI | | | New Orleans | 1985 | 1985 | Went into bankruptcy |
| PrimAir | Pennsylvania | | | | | Pittsburgh | 2009 | 2014 | Rebranded OneJet [141] |
| Primaris Airlines | Nevada | | FE | WCP | WHITECAP | Las Vegas McCarran | 2002 | 2009 | |
| Prime Air | Pennsylvania | | | | | Clarksville | 1986 | 1987 | Operated Piper [142] |
| Prime Air | Illinois | | | | | Murphysboro | 1988 | 1989 | [143] |
| Prinair | Puerto Rico | | PQ | | COLORBIRD, PRU | Ponce | 1966 | 1985 | Established as Aerolíneas de Ponce (Ponce Airlines) |
| Princeton Air Link | New Jersey | | IV | PCN | PRINCETON | Princeton | 1986 | 1988 | Operated BN Islander. Went into bankruptcy [144] |
| Princeton Airways | New Jersey | | | | | Princeton | 1978 | 1979 | Operated BN Islander, GAF Nomad [145] |
| Princeton Aviation Corporation | New Jersey | | | | | Princeton | 1950 | 1979 | Founded by Webster B. Todd and Lawrence Tokash. Participated in the Metro Air Service with A.A. in 1965 [146] |
| Princeville Airways | Hawaii | | | | | Honolulu | 1980 | 1987 | Renamed to Aloha Island Air. Operated Twin Otter [147] |
| Private Jet Expeditions | Georgia | | 5J | PJE | PEE JAY | Atlanta | 1989 | 1995 | |
| Pro Air | Florida | | | | | Miami | 1981 | 1988 | [148] |
| Pro Air | Washington | | P9 | PRH | PROHAWK | Detroit Young | 1997 | 2000 | |
| Profit Express Airlines | New York | | | | | New York Kennedy | 1945 | 1985 | Operated Convair 880 [149] [150] |
| Pronto Aviation Services | Texas | | | | | El Paso | 1982 | 1983 | Renamed to Atorie Air [151] |
| Provincetown-Boston Airlines | Massachusetts | | PT | PBA | | Provincetown | 1949 | 1989 | |
| Puertorriqueña de Aviación | Puerto Rico | | | | | | 1936 | 1941 | Also known as Aerovías Nacionales de Puerto Rico |
| Puget Sound Airlines | Washington | | | | | Bellingham | 1969 | 1970 | Formed by the merger of six local airlines. To San Juan Airlines. Operated Beech Expeditor, Cherokee Six [152] |
| Purdue Airlines | Indiana | | | | | Purdue | 1968 | 1971 | Charter operator run by Purdue University [153] |
| Q |
| Quaker City Airways | California | | | | | Burbank | 1948 | 1959 | Renamed to Admiral Airlines. Operated Boeing 307 Stratoliner [154] |
| Queen City Flying Service | Ohio | | | | | Cincinnati/Northern Kentucky | 1940 | 1970 | Operated Beech 18, C-45 Expeditor [155] |
| Quicktrans | | | | | | | | | |
| R |
| Ram Air Freight | North Carolina | | | REX | RAM EXPRESS | Raleigh Durham | 1982 | 2008 | Operated Grumman Cheetah, Piper Seneca, Piper PA-32 |
| Ramp 66 | South Carolina | | | PPK | | North Myrtle Beach | 1991 | 1994 | Operated Beech Baron, Beech Bonanza, Cessna 402 [156] |
| Ranger Airlines | Texas | | | | | El Paso | 1968 | 1970 | Scheduled third-level services [157] |
| Rankin Flying Service | Oregon | | | | | Swan Island | 1927 | n/a | Founded by Tex Rankin [13] |
| Ransome Airlines | Pennsylvania | | RZ | | | Northeast Philadelphia | 1967 | 1995 | Feeder flights for Allegheny Commuter (1970-1982), Delta Connection (1984-1987), Pan Am Express (1987-1991) and Trans World Express (1991-1995) |
| Rapid Air | | | | | | | 1965 | 2006 | Cargo operator. Known as Sparta Aviation Service |
| Rapid Air Lines | South Dakota | | | | | Rapid City | 1930 | 1933 | Merged with Hanford Airlines to form Hanford-Rapid Airlines [158] |
| Rapid City Airlines | South Dakota | | | | | Rapid City | 1928 | 1929 | Established as Pioneer Airways. Operated Curtiss Jenny [159] |
| Raritan Valley Air | New Jersey | | | | | Manville | 1966 | 1968 | Operated Beech 18, Beech Baron, Piper Apache [160] |
| Rasmark Jet Charter | Texas | | | | | El Paso | 1984 | 2000 | Operated Learjet 25, Falcon 20 [161] |
| Raven Air | Alaska | | | | | Anchorage | 1987 | 1992 | Operated Cessna aircraft [162] |
| Ravn Alaska | Alaska | | 7H | RVF | RAVN FLIGHT | Anchorage | 2014 | 2020 | Shutdown due to travel disruptions caused by the COVID-19 pandemic |
| Ray Petersen Flying Service | Alaska | | | | | Bethel | 1937 | 1945 | Acquired Bristol Bay Air Service and Jim Dodson Air Service [163] |
| RCR Air | North Carolina | | | | | Lexington | 2007 | 2014 | Operated Embraer ERJ 145 [164] |
| Reading Aviation Service | Pennsylvania | | | | | Reading | 1966 | 1966 | Operated de Havilland Dove, Beech D18S [165] |
| Rectrix Aviation | Massachusetts | | | | | Nantucket | 2005 | 2019 | |
| Red Arrow Flying Service | Florida | | | | | Miami | 1917 | 1919 | Renamed to Chalk's Flying Service Operated Stinson Voyager with floats [166] [167] |
| Red Baron Airlines | Florida | | | | | Palm Beach | 1979 | 1980 | Renamed to Florida Commuter Airlines |
| Red Carpet Airlines | Florida | | | RED | | Clearwater | 1978 | 1981 | Renamed Aerosun International. Operated Convair 340, DC-3 [168] |
| Red Wing Flying Service | Massachusetts | | | | | Ware | 1929 | 1929 | Air taxi [13] |
| Rediske Air | Alaska | | | | | Soldotna | 1991 | 2017 | |
| Redline Air Charters | Alaska | | | | | Ruby | 1996 | 2010 | [169] |
| Reeve Aleutian Airways | Alaska | | RV | RVV | REEVE | Anchorage | 1932 | 2001 | |
| Regent Air | California | | | | | Los Angeles | 1983 | 1986 | Established as First Air. Operated B-727 [170] |
| Regina Airlines | Florida | | | | | Miami | 1948 | 1960 | Operated C-46 [171] |
| RegionsAir | Tennessee | | 3C | CEA | CORP-X | Smyrna | 1996 | 2007 | |
| Reilly Air Service | California | | | | | Los Angeles | 1968 | 1971 | Operated Beech 18 [172] |
| Reliant Airlines | Michigan | | | RLT | | | 1984 | 2002 | |
| Reno Air | Nevada | | QQ | ROA | RENO AIR | Reno–Tahoe | 1992 | 1999 | Merged into American Airlines |
| Reno Air Express | California | | | | | San Jose | 1994 | 1995 | [173] |
| Renown Aviation | California | | RG | RGS | | Santa Maria | 1980 | 2000 | Established as Western Aircraft Salvage [174] |
| Republic Airlines | Minnesota | | RC | REP | REPUBLIC | Minneapolis–Saint Paul | 1979 | 1986 | Merged into Northwest Airlines |
| Resort Air | Missouri | | | | | St. Louis Lambert | 1983 | 1989 | Renamed to Trans States Airlines. Operated Swearingen Metro [175] |
| Resort Air | Rhode Island | | | | | Block Island | 1990s | 1990s | Charter carrier [176] |
| Resort Air | Oregon | | | | | Sunriver | 1992 | 1992 | Scenic tours [177] |
| Resort Airlines | California | | | | | Oakland | 1949 | 1961 | [178] |
| Resort Airlines | Florida | | | | | Miami | 1949 | 1949 | [179] |
| Resort Airlines | Maryland | | | | | Baltimore–Washington | 1982 | 1986 | Operated Piper aircraft [180] |
| Resort Airways | Hawaii | | | | | Honolulu | 1960 | 1971 | Absorbed by HATS Hawaiian Air Tour Service. Operated Aero Commander 500 [181] |
| Resort Commuter | California | | | | | Orange County | 1988 | 1995 | Operated Convair 580 [182] |
| Resort Commuter Airlines | South Carolina | | | | | | 1975 | 1979 | Renamed to Mid-South Airlines [183] |
| Resort Commuter Airlines | California | | XK | | | Orange County | 1984 | 1989 | Established as Catalina Commuter [184] |
| Rhoades International | Indiana | | | RDS | | Columbus | 1989 | 2006 | Renamed to Rhoades Aviation. Operated Convair C-131, Convair 240, DC-3, Douglas DC-6 [185] |
| Rich International Airways | Florida | | JN | RIA | RICHAIR | Miami | 1969 | 1996 | |
| Richmond Aviation | Virginia | | | | | Richmond | 1963 | 1971 | Operated Piper Twin Comanche, Twin Bonanza, Mitsubishi MU-2 [186] |
| Riddle Airlines | Florida | | | | | Miami | 1945 | 1965 | Rebranded as Airlift International |
| Rio Airways | Texas | | XO | REO | RIO | Skylark Field | 1967 | 1986 | Began as Hood Airlines |
| RKO General | Massachusetts | | | | | | 1968 | 1970 | Helicopter air taxi. Operated Bell 47, Bell 206 [187] |
| Robertson Aircraft Corporation | Missouri | | | | | Lambert Field | 1925 | 1929 | [188] |
| Robin Airlines | California | | | | | Long Beach | 1950 | 1951 | Renamed to North Continent Airlines [189] |
| Robinson Airlines | New York | | | | | Ithaca | 1945 | 1952 | Renamed to Mohawk Airlines [190] |
| Roblex Aviation | Puerto Rico | | | ROX | | San Juan | 1997 | 2013 | Cargo operator [191] |
| Rochester Aviation | Minnesota | | | | | Rochester | 1969 | 1971 | Operated Cessna 206 [192] |
| Rockford Air Charter | Illinois | | | | | Chicago Rockford | 1964 | 1971 | Operated Cessna 206, Beech 18, Piper Twin Comanche [193] |
| Rocky Mountain Airways | Colorado | | JC | RMA | ROCKY MOUNTAIN | Denver Stapleton | 1965 | 1991 | Began as Vail Airways. Merged into Continental Express |
| Rogers Heavy Lift Helicopters | California | | | | | Fresno Yosemite | 1994 | 1998 | Operated Sikorsky CH-54 Tarhe [194] |
| Roscoe Turner Aeronautical Corporation | Georgia | | | | | Candler Field | 1925 | 1928 | Operated Sikorsky S-29-A |
| Rose Aviation | California | | | | | Hawthorne | 1968 | 1969 | Operated Piper Apache, Aero Commander 500 [195] |
| Rosenbalm Aviation | Massachusetts | | | RAX | ROSIE | Willow Run | 1973 | 1991 | Became Flagship Express Services. Operated Consolidated PBY Catalina, DC-6, DC-8-63F [196] |
| Roseswift Air Service | Michigan | | | | | Grand Rapids | 1920 | 1920 | Founded by Arthur Rosenthal and Thomas Swift. Operated Curtiss Jenny [197] |
| Roswell Airlines | New Mexico | | | | | Roswell | 1976 | 1981 | Founded by Dick Callens. Operated Piper Seneca [198] |
| Roust Airways | Alaska | | | | | Nome | 1930 | 1935 | Founded by Thomas Pedersen Roust [199] |
| Royal Air | Missouri | | | | | Kansas City | 1978 | 1980 | Operated Embraer Bandeirante [200] |
| Royal American Airlines | Arizona | | | | | Tucson | 1977 | 1986 | Operated Vickers Viscount [201] [202] |
| Royal American Airways | | | | RLM | | | 1981 | 1993 | Operated Convair 240, Convair 600, Vickers Viscount [203] |
| Royal Hawaiian Air Service | Hawaii | | ZH | | | | 1971 | 1986 | Established as Hawaii Wings in 1963. Operated Cessna 402C [204] |
| Royal Hawaiian Airlines | Hawaii | | | | | Honolulu | 1985 | 1986 | [205] |
| Royal West Airlines | Nevada | | | | | Las Vegas McCarran | 1981 | 1982 | Operated DC-3 [206] |
| Royal West Airlines | Colorado | | | RWE | ROYAL WEST | Colorado Springs | 1981 | 1987 | Merged with Aero West Airlines in 1982. Operated DC-3, BAe 146 [207] |
| Royal West Airlines | Nevada | | | | | Las Vegas McCarran | 1986 | 1987 | [208] |
| Royal-Air | Arkansas | | | | | Goodwin Field | 1982 | 1982 | Established as Jamaire. Renamed to Sunbelt Airlines [209] |
| Royale Airlines | Louisiana | | OQ | RAY | ROYALE AIR | New Orleans Armstrong | 1968 | 1989 | |
| Rugby Aviation | Washington | | | | | Seattle-Tacoma | 2002 | 2007 | Renamed to Northwest Sky Ferry [210] |
| Russia Jet Direct | Washington | | RD | RYN | | Seattle–Tacoma | 2005 | 2005 | |
| Ryan Air | Alaska | | | | | Anchorage | 1979 | 1988 | Established as Unalakleet Air Taxi. Renamed to Arctic Transportation Services [211] |
| Ryan Airline Company | California | | | | | San Diego | 1925 | 1926 | |
| Ryan International Airlines | Illinois | | RD | RYN | RYAN | Chicago Rockford | 1972 | 2013 | |
| S |
| S.I. Airways | Texas | | | | | Amarillo | 1974 | 1975 | [212] |
| S.S. Airways | Kansas | | | | | Amarillo | 1972 | 1972 | Renamed to Century Airlines [213] |
| Saber Aviation | | | SP | SBR | | | 1978 | 1991 | [214] |
| Safeway Airlines | Alaska | | | | | Fairbanks | 1964 | 1968 | Operated Piper Apache, Piper Comanche, Cherokee Six [215] |
| Sair | New York | | | | | Syracuse | 1961 | 1999 | [216] |
| Salair | Alaska | | | 8S | SIR | Anchorage | 1980 | 1997 | Operated DC-3, Convair 440. Renamed to Air Alaska Cargo |
| Salmon Air | Idaho | | S6 | MBI | | Boise | 1968 | 2009 | Merged into McCall Aviation |
| Samoa Air | American Samoa | | | | | Pago Pago | 1987 | 2003 | |
| San Diego Sky Freight | California | | | | | San Diego | 1950 | 1952 | Cargo operator [217] |
| San Francisco and Oakland Helicopter Airlines | California | | OH | | SFO AIRLINES | San Francisco | 1961 | 1986 | |
| San Juan Airlines | Washington | | | | | Port Angeles | 1947 | 1989 | Commuter operator [218] |
| San Juan Airlines | | | YS | | | | 1970 | 1989 | Merged into Alaska Airlines [219] |
| San Marino Taxi Aereo | California | | | | | Long Beach | 1999 | 2003 | [220] |
| Santa Fe Airline Company | New Mexico | | | | | Santa Fe | 1972 | 1972 | Intrastate air carrier [221] |
| Santa Fe Skyway | | | | | | | 1946 | 1947 | [222] |
| Santa Maria Airlines | California | | | | | Hancock Field | 1928 | 1935 | Founded by George Allan Hancock [223] |
| SAT-Air | Texas | | | | | San Antonio | 1983 | 1995 | Renamed to Merlin Express [224] |
| Satellite Aero | Wyoming | | | | | Jackson Hole | 1990 | 1995 | Operated Cessna 206, Cessna 402C, Piper Navajo [225] |
| Saturn Airways | California | | KS | | | Oakland | 1961 | 1976 | Absorbed into Trans International Airlines |
| Sawyer Aviation | Arizona | | | | | Phoenix Sky Harbor | 1961 | 1998 | Operated Cessna 182, Cessna 425C, Cessna Citation [226] |
| SB Air | Texas | | | | | Dallas Love Field | 1999 | 2019 | Established as Seven Bar Flying Services. Renamed to SevenBar Aviation. Medical transport operator. [227] |
| Scanderbeg Air | New York | | P1 | | | New York Kennedy | 2009 | 2009 | Charter carrier [228] |
| SCAT South Central Air Transport | Arkansas | | | | | Fayetteville | 1946 | 1948 | Operated Cessna UC-78 [229] |
| Scenic Air | California | | | | | Columbia | 1994 | 1995 | [230] |
| Scenic Air Tours Hawaii | Hawaii | | | | | Honolulu | 1992 | 1996 | [231] |
| Scenic Airlines | Nevada | | YR | YRR | | North Las Vegas | 1967 | 2007 | Acquired by Grand Canyon Airlines and renamed to Grand Canyon Scenic Airlines [232] |
| Scenic Airways | Arizona | | | | | Grand Canyon | 1927 | 1930 | Renamed to Grand Canyon Airlines [233] |
| Scheduled Skyways | Arkansas | | | | | Fayetteville | 1953 | 1972 | Merged into Air Midwest |
| Scheerer Air | Florida | | | | | Palm Beach | 1979 | 1980 | Merged into Florida Commuter Airlines [234] |
| Seaboard & Western Airlines | New York | | | | | New York Kennedy | 1947 | 1961 | Renamed to Seaboard World Airlines [235] |
| Seaboard World Airlines | New York | | SB | SEW | SEABOARD | New York Kennedy | 1946 | 1980 | As Seaboard & Western Airlines, merged into Flying Tiger Line |
| Seaco Airlines | Michigan | | | | | Detroit Metro | 1976 | 1980 | Operated Cessna 402, Piper Aztec [236] |
| Seacoast Air Transport | Massachusetts | | | | | New Bedford | 1937 | 1939 | [237] |
| SeaCoast Airlines | Florida | | | SCC | SEA-COASTER | St. Pete–Clearwater | 2002 | 2012 | |
| Seagull Air | Alaska | | | | | Bethel | 1988 | 1989 | Founded by J. Timothy Cracie [238] |
| Seagull Air Lines | Utah | | | | | Salt Lake City | 1929 | 1930 | Operated Curtiss Robin [239] |
| Seair Alaska Airlines | Alaska | | | | | Anchorage | 1980 | 1986 | Established as Sea Airmotive. Operated Convair 440, Twin Otter [240] |
| Seaplanes of Key West | Florida | | | | | Key West | 2004 | 2006 | [241] |
| SeaPort Airlines | Oregon | | K5 | SQH | SASQUATCH | Portland | 2008 | 2016 | Went into bankruptcy [242] |
| Seattle Air Charter | Washington | | | | | Seattle-Tacoma | 1947 | 1949 | [243] |
| Seattle Commuter Airlines | Washington | | | | | Seattle-Tacoma | 1965 | 1968 | Scheduled commuter air services [244] |
| Seattle Flying Services | Washington | | | | | Seattle | 1930 | 1930 | Founded by Vern Gorst [245] |
| Seattle-Victoria Airmail Line | Washington | | | | | Seattle | 1919 | 1919 | Established as Hubbard Air Transport [246] |
| Sentinel Airlines | Texas | | | | | Abilene | 1971 | 1971 | Operated Cessna 402 [247] |
| Seven Bar Flying Services | Texas | | | | | Dallas Love Field | 1947 | 1999 | Medical transport operator. Renamed SB Air [248] |
| Seven Seas Airlines | California | | | | | Burbank | 1957 | 1961 | Operated C-46, DC-4 [249] |
| Severson Air Activities | Montana | | | | | Great Falls | 1964 | 1971 | Operated Cessna 182, Cessna 320 [250] |
| Seward Airways | Alaska | | | | | Seward | 1937 | 1939 | Founded by John Littley [251] |
| Shalkow Air Cargo Express | Ohio | | | | | Cleveland Hopkins | 1982 | 1989 | Established as Ace Air Cargo Express. Operated C-47 [252] |
| Shasta Air | California | | | | | Yreka Rohrer Field | 1968 | 1983 | Operated Piper Navajo [253] |
| Shavano Air | Colorado | | | SHV | SHAVANO | Harriet Alexander Field | 1960 | 2002 | |
| Shawnee Airlines | Florida | | XW | SHW | SHAWNEE | Orlando Executive | 1968 | 1975 | Acquired by Florida Airlines [254] |
| Shawnee Airways | Ohio | | | | | Akron–Canton | 1961 | 1972 | Founded by Ernest Stadvec [255] |
| Sheffield P. Wilds | South Carolina | | | | | | 196 | 1971 | Operated Aero Commander 500, Piper Apache [256] |
| Shelby Sky Haven | Ohio | | | | | Mansfield | 1948 | 1963 | Renamed to GCS Air Service [257] |
| Shelter Charter Services | Georgia | | | | | Atlanta | 2017 | 2017 | Operated Cessna Citation I [258] |
| Shelton-Jefferson Airways | Missouri | | | | | St. Louis Lambert | 1930 | 1931 | Operated Ogden Osprey [13] |
| Shenandoah Airlines | Virginia | | | | | Charlottesville–Albemarle | 1968 | 1970 | Operated Beech E18S [259] |
| Shoreline Aviation | Connecticut | | | | | Tweed New Haven | 1980 | 2020 | Operated Cessna Caravan seaplane [260] |
| Shorter Airlines | Michigan | | | | | Pellston Regional | 1968 | 1975 | Operated Beech E18S, DC-3 [261] |
| Shuttle Air Lines | California | | | | | Glendale Grand Central | 1931 | 1932 | Operated Ogden Osprey [13] |
| Shuttle America | Indiana | | S5 | TCF | MERCURY | Chicago O'Hare | 1995 | 2017 | Republic Airways Holdings merged into another subsidiary |
| Shuttle by United | California | | UA | UAL | UNITED | San Francisco | 1994 | 2001 | Subsidiary of United Airlines, renamed United Shuttle |
| Sidles Airways | Nebraska | | | | | Lincoln | 1930 | n/a | Operated Stinson Detroiter (NC7474) [13] |
| Siemans Air Transport | Pennsylvania | | | | | Uniontown | 1927 | n/a | Founded by Charles L. Siemans [13] |
| Sierra Expressway | California | | | SRX | SIERRA EX | Oakland | 1994 | 1996 | [262] |
| Sierra Mountain Airways | California | | | | | Oakland | 1987 | 1989 | [263] |
| Sierra Nevada Airways | Nevada | | ZS | | | Las Vegas McCarran | 1984 | 1997 | Operated Beech Baron, Cessna 402C [264] |
| Sierra Pacific Airlines | California | | | | | Oakland | 1965 | 1966 | Operated Beech 18 [265] |
| Sierra Pacific Airlines | Arizona | | | | | Tucson | 1976 | 1982 | [266] |
| Sierra West Airlines | California | | | | | Van Nuys | 1974 | 1975 | Operated Beech Queen Air [267] |
| Silver State Airlines | Nevada | | | | | Las Vegas McCarran | 1979 | 1982 | Charter carrier [268] |
| Silver State Helicopters | Nevada | | | | | Henderson Executive | 1999 | 2008 | |
| Silver Wings Aviation | South Dakota | | | | | Rapid City | 1975 | 1976 | [269] |
| Simmons Airlines | Michigan | | MQ | SYM | SIMMONS | Marquette | 1978 | 1998 | Merged into American Eagle Airlines |
| Sis-Q Flying Service | California | | | | | Sonoma County | 1962 | 1979 | Aerial fire fighting. Operated Grumman Tigercat [270] |
| Sisk Aviation Activities | Illinois | | | | | St. Louis Downtown | 1964 | 1977 | Third-level services [271] |
| Sizer Airways | North Dakota | | | | | Fargo-Hector Field | 1970 | 1979 | Established as Luthi Aviation. Operated Beech 18, Riley Rocket [272] |
| Skagway Air Service | Alaska | | 7J | SGY | | | 1964 | 2007 | [273] |
| Sky Bus Public Charter | Florida | | | | | Fort Lauderdale | 1993 | 1993 | Operated Boeing 727-200 [274] |
| Sky Courier | | | | | | | 1988 | 1988 | To Airborne Express [275] |
| Sky Harbor Air Service | Nebraska | | NE | SKD | SKY DAWG | Omaha | 1954 | 1970 | [276] |
| Sky Harbor Air Services | Wyoming | | WY | SHC | SKY HARBOR CHEYENNE | Cheyenne | 1988 | | [277] |
| Sky King | Florida | | 5K | SGB | SONGBIRD | Miami | 1990 | 2015 | Rebranded as Songbird Airways |
| Sky Tours | Massachusetts | | | | | | 1947 | 1953 | Established as Erie Isle Airways. Renamed to Island Airlines [278] |
| Sky Tours Hawaii | Hawaii | | | | | | 1965 | 1971 | [279] |
| Sky Trek International Air Lines | Virginia | | | | | Richmond | 1996 | 2000 | Renamed Discovery Airways in 1999 |
| Sky Trucks International | Florida | | | | | Fort Lauderdale | 1972 | 1975 | [280] |
| Skybus Airlines | Ohio | | SX | SKB | SKYBUS | Columbus | 2004 | 2008 | |
| Skybus Express | Georgia | | | | | Atlanta | 1991 | 1992 | Operated GAF Nomad |
| Skycoach Express | California | | | | | | 1953 | 1954 | Founded by Irving E. Herman. Operated C-46 [281] |
| Skyfreighters | Texas | | | | | Grand Prairie | 1984 | 1991 | Established as Coker Airfreight. Acquired by Kitty Hawk Airways. Operated Douglas C-117D [282] |
| Skyfreight Airlines | Florida | | | | | Miami | 1981 | 1984 | Operated DC-3 [283] |
| Skyline Air Service | Washington | | | | | Seattle-Tacoma | 1967 | 1969 | Founded by Tom Wilson. To Puget Sound Airlines [284] |
| Skyline Motors Aviation Services | Ohio | | | | | Youngstown–Warren | 1979 | 1981 | Renamed to B.A.S Airlines [285] |
| Skylink Airways | Maryland | | | | | Washington Dulles | 2003 | 2005 | Rebranded as MAXjet Airways |
| Skymark Airlines | California | | | | | Sacramento Executive | 1968 | 1969 | [286] |
| Skymaster Air Taxi | New Hampshire | | 8M | SDD | SKY DANCE | Laconia | 1989 | 1993 | Renamed Atlantic North Airlines [287] |
| Skyservice USA | Colorado | | | | | Chicago Rockford | 1998 | 2000 | |
| Skystar International | Virginia | | | SSK | | Washington National | 1984 | 1987 | International pilgrimage [288] |
| Skystream Airlines | Illinois | | DN | | | Chicago Meigs Field | 1973 | 1980 | Founded by Cecil Pond. Acquired Hub Airlines [289] |
| SkyValue | Florida | | XP | CXP | RUBY MOUNTAIN | Fort Lauderdale-Hollywood | 2006 | 2007 | |
| SkyValue Airways | Michigan | | 4A | DYN | | Oakland County | 2018 | 2018 | [290] |
| Skyvan Airways | | | | | | | 1963 | 1964 | Operated C-46 [291] |
| Skyway Airlines (Skyway Aviation) | Missouri | | ZY | | | Forney Field | 1960 | 1979 | Air taxi operator [292] |
| Skyway Airlines | | | | | | | 1968 | 1980 | Known as Skyway Commuter. Operated Beech E18S [293] |
| Skyway Airlines | Wisconsin | | AL | SYX | SKYWAY-EX | Milwaukee Mitchell | 1994 | 2008 | |
| Skyway Commuter | Florida | | | | | Ocala | 1984 | 1985 | Established ad Skyway of Ocala [294] |
| Skyway of Ocala | Florida | | | | | Ocala | 1981 | 1984 | Operated as Air Florida Commuter [295] |
| Skyways International | Florida | | | | | Miami | 1946 | 1951 | Operated C-46, DC-3, Lockheed Lodestar [296] |
| Skyways International | Florida | | | | | Miami | 1969 | 1972 | Renamed to Transair Cargo [297] |
| Skyways International | Texas | | | | | Houston Bush | 1978 | | [298] |
| Skyworld Airlines | Colorado | | PC | SPC | | Denver | 1986 | 1992 | Formerly Denver Ports of Call |
| Slick Airways | Texas | | | | | Hollywood Burbank | 1946 | 1966 | To Airlift International |
| Slocum Airlines | Florida | | | SLO | SLOCUM | Miami | 1981 | 1984 | Operated as Air Florida Commuter [299] |
| Small Community Airlines | Florida | | | | | Dallas Love Field | 2007 | 2009 | Operated BAE Jetstream [300] |
| SMB Stage Lines | Texas | | MJ | STG | STAGE | Dallas Fort Worth | 1967 | 1990 | Operated Convair 580, Convair 600, DC-3 [301] |
| Smokers Express | Florida | | | | | Orlando Melbourne | 1993 | 1993 | Not launched |
| Smyer Aircraft | Kansas | | | | | Strother Field | 1968 | 1972 | Operated Cessna 206, Cherokee Six [302] |
| Solar Airlines | New Mexico | | | | | Roswell | 1964 | 1971 | Operated Beech 18, Dumod Infinité I, PacAero Tradewind [303] |
| Soldotna Air Service | Alaska | | | | | Soldotna | 1978 | 1979 | [304] |
| Song | Georgia | | DL | DAL | DELTA | Atlanta | 2003 | 2006 | Merged back in with its parent company, Delta Air Lines |
| Songbird Airways | Florida | | 6K | SGB | SONGBIRD | Orlando | 1990 | 2017 | Began as Sky King Inc. [305] |
| Sonora Air Lines | Nevada | | | | | Reno–Tahoe | 1967 | 1971 | Operated Cessna 150, Cessna 172, Piper PA-23 [306] |
| Sourdough Air Transport | Alaska | | | | | Fairbanks | 1953 | 1962 | [307] |
| South Atlantic Airlines | South Carolina | | | | | Myrtle Beach | 1968 | 1969 | Operated Aero Commander 500, Turbo Commander 690 [308] |
| South Bend Airways | Indiana | | | | | Cadet Field | 1927 | n/a | Founded by Stephen Darius, Carl G Jordan. Operated Pheasant H-10 [13] |
| South Central Air | Alaska | | | SCA | | Kenai | 1967 | 2001 | Founded by Harold and Irene Andersen. Operated BAe Jetstream 31, BN Islander, Cessna [309] |
| South Central Air Transport (SCAT) | Mississippi | | | | | Natchez–Adams | 1971 | 1977 | [310] |
| South Central Airlines | Florida | | | | | Ocala | 1963 | 1964 | [311] |
| South East Airline | | | | | | | | | |
| South Pacific Air Lines | California | | | | | | 1960 | | |
| South Pacific Island Airways | Hawaii | | HK | SPI | SOUTH PACIFIC | Honolulu | 1973 | 1987 | |
| South Winds Cargo | Florida | | WE | SWC | | Miami | 2002 | 2005 | Merged into Centurion Cargo. Operated DC-10 |
| Southcentral Air | Alaska | | XE | SCA | SOUTH CENTRAL | Kenai | 1975 | 1999 | [312] |
| Southeast Airlines | Tennessee | | SL | | SOUTHEAST | Tri-Cities | 1956 | 1959 | [313] |
| Southeast Airlines | Florida | | NS | SEA | SOUTHEAST AIR | Miami | 1966 | 1981 | Originally known as Cat Cay Airlines [311] |
| Southeast Airlines | Florida | | Sl | SNK | | Youngstown–Warren | 1999 | 2004 | |
| Southeast Airlines (Southeastern Aviation) | Tennessee | | | | | Jackson | 1960 | 1979 | Operated de Havilland Dove [314] |
| Southeast Skyways | Alaska | | SE | | | Juneau | 1968 | 1983 | Founded by Dean Williams and Billy Bernhardt. Operated Cessna 207, DHC Beaver [315] |
| Southeastern Commuter Airlines | Georgia | | | | | Atlanta | 1973 | 1983 | Acquired by Atlantic Southeast Airlines |
| Southern Air Transport (1929) | Texas | | | | | | 1929 | 1929 | Controlled by Avco, the company that organized American Airlines |
| Southern Air Transport | Florida | | SJ | SJM | SOUTHERN AIR | Miami | 1947 | 1998 | To Southern Air |
| Southern Airlines | Florida | | | | | | 1981 | 1981 | Rebranding Florida Commuter Airlines [316] |
| Southern Airlink | Mississippi | | | | | Bay Springs | 1996 | 1997 | [317] |
| Southern Airways | Georgia | | SO | SO | SOUTHERN | Atlanta | 1949 | 1979 | Merged with North Central Airlines to form Republic Airlines (1979–1986) |
| Southern Airways | Mississippi | | | | | Jackson–Medgar | 1985 | 1987 | Established a Flight Line [318] |
| Southern Aviation | Oklahoma | | | | | Lawton | 1964 | 1974 | Operated Cessna 182, Cessna 206 [319] |
| Southern Cross Airways | | | | | | | 1959 | 1960 | Operated C-46 [320] |
| Southern Express | Florida | | | | | | 1984 | 1986 | Formerly known as Finair Express [321] |
| Southern International Airways | Florida | | | | | | 1981 | 1981 | Successor of Florida Airlines operated as Air Florida Commuter [322] |
| Southern Jersey Airways | New Jersey | | 6J | ALC | ACOM | Cape May | 1946 | 1991 | Established as Atlantic City Airlines operating as Allegheny Commuter [323] |
| Southern Jersey Resorts Airways | New Jersey | | | | | Atlantic City | 1965 | 1990 | Operated Twin Otter, Dash-8 [324] |
| Southern Maryland Aviation | Maryland | | SF | | | St. Mary's County | 1977 | 1979 | [325] |
| Southern Nevada Airlines | Nevada | | | | | | 1980 | 1981 | [326] |
| Southern Skyways | Georgia | | | | | Atlanta | 1980 | | A virtual airline (economics) which markets air travel branding |
| Southwest Air Fast Express | Oklahoma | | | | | St. Louis Lambert | 1928 | 1929 | Acquired by American Airlines |
| Southwest Airlines | Texas | | | | | San Antonio | 1965 | 1967 | Established as Wild Goose Flying Service [327] |
| Southwest Airways | California | | | | | San Francisco | 1941 | 1958 | Renamed to Pacific Air Lines |
| Southwest Ryan Airlines | Indiana | | | | | McIntyre Field | 1928 | n/a | Operated Ryan Brougham [13] |
| Special Aviation Systems | Michigan | | | | | | 2001 | 2004 | Cargo carrier. Operated Embraer Bandeirante [328] |
| Speed Star Express | California | | | | | | 1968 | 2005 | Operated Twin Otter [329] |
| Spirit Air | Alaska | | | | | | 2005 | 2009 | Commuter and package carrier [330] |
| Spirit Aviation | California | | | | | Van Nuys | 1994 | 1995 | Charter operator [331] |
| Spirit Lake Airways | Iowa | | | | | Spencer | 1977 | 1979 | Renamed to Great Lakes Airlines [332] |
| Spirit of America Airlines | California | | IM | IAS | BOXHALUER | Los Angeles | 1959 | 1989 | Established as IASCO [333] |
| Spokane Airways | Washington | | | | | Spokane | 1990 | 2012 | [334] |
| Sports Air Travel | Oregon | | | WCC | WEST COAST | Portland–Troutdale | 1982 | 1999 | [335] |
| Sports Air Travel | California | | | | | Burbank | 1997 | 1997 | To Ameriflight [336] |
| Sports by Air | South Carolina | | | | | Hilton Head | 1968 | 1971 | Operated Aero Commander 680 [337] |
| Sportsflight Airways | Arizona | | | | | Tucson | 1993 | 1995 | Renamed to Pacific International Airlines [338] |
| St. Germain Aviation | Illinois | | | | | Meigs Field | 1964 | 1971 | Operated Piper Twin Comanche [339] |
| St. Petersburg–Tampa Airboat Line | Florida | | | | | St. Petersburg | 1914 | 1914 | |
| Stadvec Aviation | Illinois | | | | | Akron–Canton | 1958 | 1961 | Founded by Ernest Stadvec. Operated Piper PA-22 Tri-Pacer [340] |
| Stagecoach Airways | Texas | | | | | San Antonio | 1958 | 1961 | Operated Beech Twin Bonanza, Lockheed L.12 Electra [341] |
| Standard Air Cargo | California | | | | | San Diego | 1946 | 1953 | Renamed to Standard Airways [342] |
| Standard Air Lines | California | | | | | Los Angeles | 1927 | 1930 | Subsidiary of Aero Corporation of California. In 1930 acquired by Western Air Express |
| Standard Air Lines | California | | | | | Oakland | 1945 | 1957 | Established as Fireball Air Express [343] |
| Standard Airways | California | | FD | | | San Diego | 1953 | 1968 | Established as Standard Air Cargo [344] |
| Standard Airways | Michigan | | | | | Pontiac | 1966 | 1969 | Operated Beech 18, Piper Navajo [345] |
| Star Air Service | Alaska | | | | | Anchorage | 1932 | 1944 | Renamed to Alaska Airlines |
| Starflight | Nevada | | | | | Reno–Tahoe | 1975 | 1975 | Operated BAC One-Eleven [346] |
| Starlight Express | | | | | | | 1987 | 1991 | Cargo feeder for FedEx Express [347] |
| Starflite | New York | | | | | White Plains | 1965 | 1966 | Contract service operator [348] |
| Starship Airlines | Arizona | | | | | Tucson | 1991 | 2000 | Operated Convair 240C, Convair 440F [349] |
| Starstruck Jet | Tennessee | | | | | Nashville | 1998 | 1998 | [350] |
| State Airlines | South Carolina | | | | | Charlotte Douglas | 1940 | 1940 | Operated Lockheed Lodestar, Bellanca Cruisair [13] |
| State Airlines | Florida | | | | | Ft. Lauderdale | 1981 | 1984 | [351] |
| StatesWest Airlines | Arizona | | YW | SWJ | STATES | Phoenix Sky Harbor | 1986 | 1993 | |
| Stateswide Airline | New Hampshire | | | | | Manchester–Boston | 1964 | 1965 | Operated de Havilland Dove [352] |
| Stearns Air Alaska | Alaska | | | | | Anchorage | 1992 | 2001 | [353] |
| Stewart Air Service | California | | | | | Los Angeles | 1946 | 1971 | [354] |
| Stol Air Commuter | California | | VB | | | Fresno Yosemite | 1972 | 1978 | Renamed WestAir Commuter Airlines [355] |
| Stout Air Services | Michigan | | | | | Ford Airport | 1925 | 1930 | Purchased by National Air Transport |
| Strachan Skyways | Georgia | | | | | Hunter Field | 1936 | 1938 | [356] |
| Streamline Air | Massachusetts | | | SRY | STINGRAY | Hanscom Field | 2010 | 2012 | |
| Suburban Airlines | | | AL | | | DuBois | 1968 | 1989 | To Allegheny Airlines |
| Suburban Airways | California | | | | | | | | |
| Summit Airlines | Pennsylvania | | DU | SMM | SUMMITAIR | Philadelphia | 1966 | 1986 | Established as Del Air Cargo Airlines [357] |
| Summit Airways | Colorado | | | | | Denver | 1946 | 1947 | Established as Challenger Airlines [358] |
| Summit Aviation | Florida | | | | | Miami | 1999 | 1999 | Charter operator [359] |
| Sumo Airlines | New York | | SM | | | New York Kennedy | 1988 | 1996 | Cargo operator. Operated Piper Lance [360] |
| Sun Air Express | Florida | | | | | Fort Lauderdale | 2014 | 2016 | Acquired by Southern Airways Express [361] |
| Sun Air International | Florida | | | | | Fort Lauderdale-Hollywood | 2011 | 2014 | Rebranded as Sun Air Express |
| Sun Aire Lines | California | | OO | | | Palm Springs | 1968 | 1984 | Established as Borrego Springs Airlines. Merged into SkyWest Airlines |
| Sun Airlines | Missouri | | | | | St. Louis Lambert | 1967 | 1970 | Founded by George Caleshu. Operated Beech 18, Twin Otter, de Havilland Heron [362] |
| Sun Airlines | Florida | | YX | | | | 1969 | 1978 | [363] |
| Sun Jet International | Florida | | JX | SJI | SUNJET | St. Pete–Clearwater | 1993 | 1997 | Founded by Tom Kolfenbach. Renamed to Southeast Airlines [364] |
| Sun Land Airlines | Nevada | | RF | | | Reno | 1980 | 1981 | Operated single Boeing 737-200 [365] |
| Sun Pacific International | Arizona | | | SNP | | Tucson | 1995 | 1999 | Operated Boeing 727-200 [366] |
| Sun Valley Airlines | Utah | | | | | Salt Lake City | 1964 | 1972 | Established as Janss Airways in 1964. Acquired by Key Airlines [367] |
| Sun Valley Key Airlines | Idaho | | | | | Friedman Memorial | 1968 | 1972 | Formerly Sun Valley Airlines renamed to Key Airlines |
| Sun West Airlines | Arizona | | KY | SNW | SUN WEST | Phoenix Sky Harbor | 1980 | 1985 | |
| Sunaire Express | Virgin Islands | | OY | SUA | SUNBIRD | Saint Croix Rohlsen | 1982 | 1994 | Went in bankrupt [368] |
| Sunbelt Airlines | Arkansas | | JM | BTR | | Harrell Field | 1979 | 1984 | Known as Jamaire until March 1982 [369] |
| Sunbird Air | Florida | | | | | Fort Lauderdale | 1984 | 1989 | Operated Convair 440 [370] |
| Sunbird Airlines | North Carolina | | ED | SBD | SUNBIRD | Charlotte Douglas | 1979 | 1987 | Absorbed by Atlanta Express. Became CCAir in 1986. [371] |
| Sunbird Airlines | Tennessee | | | | | Nashville | 1980 | 1980 | Operated Piper Cherokee Six [372] |
| Sunbird Airways | Florida | | B6 | | | Orlando | 1993 | 1996 | [373] |
| SunCoast Airlines | Florida | | WS | | | | 1987 | 1988 | Went in bankrupt |
| Sunjet Aviation | Florida | | | | | Orlando Sanford | 1997 | 1999 | Operated Cessna Citation V, Learjet 35 [374] |
| Sunrise Airlines | Nevada | | OQ | SDC | SUNDANCE | Las Vegas McCarran | 1967 | 2000 | Established as Lake Powell Air Service [375] |
| Sunwest International | | | | | | | | | |
| Sunworld International Airlines | Kentucky | | SM | SWI | SUNWORLD | Cincinnati/Northern Kentucky | 1996 | 2004 | |
| Sunworld International Airways | Nevada | | JK | SWI | SUNWORLD | Las Vegas McCarran | 1983 | 1988 | Established as Jetwest International Airways |
| Supair | California | | | | | Buchanan Field | 1950 | 1953 | Operated DC-3 [376] |
| Superior Air | West Virginia | | | | | Fairmont | 1972 | 1973 | Operated BN Islander [377] |
| Superior Airlines | Georgia | | | | | Atlanta | 1960 | 1963 | Operated de Havilland Dove, Aero Commander [378] |
| Superior Airlines | Indiana | | | | | | 1961 | 1962 | |
| Superior Airlines | Arizona | | | | | Columbus Glenn | 1994 | 2003 | To Mesa Airlines |
| Susquehanna Airways | New York | | | | | Sidney | 1979 | 1985 | Established as Forde-Aire. Operated Riley Turbo Skyliner, Piper Aztec [379] |
| Swift Air | Florida | | WQ | SWQ | SWIFTFLIGHT | Miami | 1997 | 2019 | Renamed to iAero Airways |
| Swift Aire Lines | California | | WI | | | San Luis Obispo | 1969 | 1981 | Merged with Golden Gate Airlines |
| Swissjets | Florida | | | | | Fort Lauderdale | 2000 | 2001 | Renamed to Tourjets [380] |
| T |
| T & G Aviation | Arizona | | | | | Buckeye | 1990 | 2000 | Renamed to International Air Response. Operated Douglas DC-6, Douglas DC-7B [381] |
| TAB Express Airlines | Florida | | | TBI | TAB | Orlando Melbourne | 1992 | 2005 | Operated Beech 1900 [382] |
| TAG Airlines | Michigan | | | | | Detroit City | 1959 | 1970 | Shut down following crash |
| Tahoe Air | California | | XP | CXP | CASINO EXPRESS | Lake Tahoe | 1999 | 1999 | |
| Taku Glacier Air Gold | Alaska | | | | | Juneau | 1984 | 1994 | Operated Cessna Stationair, DHC Beaver [383] |
| Talkeetna Air Service | Alaska | | | | | Talkeetna | 1947 | 1948 | Renamed to Talkeetna Air Taxi [384] |
| Tamgass Aviation | Alaska | | | | | | 1964 | 1969 | Renamed to Southcoast Airways [385] |
| Tanana Air Taxi | Alaska | | | | | Tanana | 1972 | 1974 | Renamed to Alaska Central Airways [386] |
| Tanner Airlines | California | | | | | Los Angeles | 1930s | 1930s | Operated Stinson Detroiter [13] |
| TapJets | North Dakota | | | | | Fargo Hector | 2016 | 2018 | [387] |
| Taquan Air Service | Alaska | | | | | Ketchikan | 1977 | 2000 | Renamed to Taquan Air. Operated DHC Beaver [388] |
| Tar Heel Aviation | North Dakota | | | THC | TARHEEL | Jacksonville Ellis | 1975 | 2000 | [389] |
| Tatonduk Flying Service | Alaska | | | | | Eagle | 1977 | 1980 | Renamed to Everts Air Alaska. Operated Cessna 180 [390] |
| Taxi Air Group | Ohio | | | | | Cleveland Burke Lakefront | 1955 | 1957 | Founded by William Knight. Renamed to TAG Airlines. Operated DHC Otter [391] |
| Ted | Illinois | | UA | UAL | UNITED | Denver | 2004 | 2009 | Merged back into parent company United Airlines |
| Tejas Airlines | Texas | | TB | | | San Antonio | 1976 | 1980 | Filed for Chapter 11 bankruptcy [392] |
| Telair International | | | | | | | | | |
| Telford Aviation | Maine | | | | | | 1995 | 2004 | [393] |
| Tempelhof Airways | Florida | | | TEH | TEMPELHOF | Fort Lauderdale | 1981 | 1990 | Operated from West Berlin |
| Temple Airlines | | | | | | | 1968 | 1968 | [394] |
| Tempus Jets | South Carolina | | | | | Greenville–Spartanburg | 2007 | 2018 | Executive jet charter. Went in bankrupt [395] |
| TEMSCO Airlines | Alaska | | | | | Ketchikan | 1986 | 1991 | The helicopter division continue to operate as TEMSCO Helicopters Inc. [396] |
| Tennessee Airways | Tennessee | | ZN | TEN | TENNESSEE | Knoxville McGhee | 1978 | 1990 | Operated Embraer Bandeirante [397] |
| TennesseeSkies | Tennessee | | | | | Nashville | 2009 | 2012 | A Pacific Wings subsidiary |
| Tepper Aviation | Florida | | | | | Crestview | 1987 | 2006 | [398] |
| Texas International Airlines | Texas | | TI | TIA | TEXAS | Houston-Hobby | 1944 | 1982 | Formed as Aviation Enterprises, became Trans-Texas Airways (1947), merged into Continental Airlines |
| Texas National Airlines | Texas | | | TXN | TEXAS NATIONAL | San Antonio | 1986 | 1988 | Established as Border Airlines [399] |
| The Air-Oasis Co | California | | | | | Long Beach | 1963 | 1963 | Operated DC-3 [400] |
| The Gulf Coast Airline | Louisiana | | | | | New Orleans | 1923 | 1932 | Renamed to Johnson Airways [401] |
| The Hagerstown Commuter | Maryland | | | | | Hagerstown | 1962 | 1983 | Operated as an Allegheny Commuter [402] |
| The Hawaii Express | Hawaii | | LP | HEA | | Los Angeles | 1982 | 1983 | |
| The Lord's Airline | Florida | | 5Q | | | Miami | 1986 | 1987 | |
| The Maui Commuter | Hawaii | | | | | Kahului | 1975 | 1978 | Founded by Jack Holzman and Robert Frost. Established as Ananda Air [403] |
| Thompson Aeronautical Corporation | Ohio | | | | | Cleveland | 1928 | 1932 | Renamed to Transamerican Airlines [13] |
| Thor Solberg Aviation | New York | | | | | Curtiss Field | 1929 | 1930 | Operated Great Lakes 2-T-1, Bellanca CH-200 [404] |
| Thunderbird Airlines | Utah | | | | | Ogden-Hinckley | 1964 | 1969 | Renamed to Key Airlines. Operated Twin Otter [405] |
| Tibben Flight Lines | Iowa | | | | | Cedar Rapids | 1992 | 1996 | Charter operator [406] |
| TMA Trans-Michigan Airlines | Michigan | | | | | Traverse City | 1969 | 1972 | Cargo carrier [407] |
| TMC Airlines | Michigan | | | TMM | WILLOW RUN | Willow Run | 1994 | 2005 | Cargo carrier. Operated L-188, DC-8 [408] |
| Tol Air | Puerto Rico | | TI | TOL | TOL AIR | | 1983 | 2006 | Acquired by Four Star Air Cargo |
| Tourjets | Florida | | | | | Fort Lauderdale | 2001 | 2002 | Established as Swissjets [409] |
| Tower Air | New York | | FF | TOW | TEE AIR | New York Kennedy | 1983 | 2000 | |
| TPA-The Aloha Airline | Hawaii | | | | | Honolulu | 1950 | 1958 | Established as Trans-Pacific Airlines [410] |
| TPI International Airways | Georgia | | UF | | | Brunswick Golden Isles | 1989 | 1996 | [411] |
| Tradewinds Airlines | North Carolina | | WI | TDX | TRADEWINDS EXPRESS | Piedmont Triad | 1991 | 2010 | |
| Trans Air | Florida | | GO | TRA | TRANS ISLAND | Fort Lauderdale–Hollywood | 1982 | 1986 | Established as Trans Island Airways [412] |
| Trans Air Lines | Louisiana | | | | | New Orleans Armstrong | 1962 | 1963 | Renamed to Air Lines. Operated Aero Commanders [413] |
| Trans Air Link | Florida | | | | | Miami | 1986 | 1989 | [414] |
| Trans Alaskan Airlines | Alaska | | | | | Anchorage | 1955 | 1963 | Operated DC-4, DC-6A, PBY-5A Catalina [415] |
| Trans American Charter | Illinois | | | ECQ | | Chicago O'Hare | 1992 | 1995 | [416] |
| Trans Caribbean Airways | New York | | TR | TCA | | | 1945 | 1971 | Acquired by American Airlines |
| Trans Continental Airlines | Michigan | | TD | TCN | TRANSCOM | Willow Run | 1974 | 1992 | Established as International Airlines Academy. Rebranded as Express.Net Airlines |
| Trans East Airlines | New Hampshire | | | | | Manchester–Boston | 1963 | 1972 | Formed as Statewide Airlines |
| Trans East International | New York | | | | | Farmingdale | 1982 | 1984 | Established as New York Air. Renamed to Island Air. Operated Twin Otter, Embraer Bandeirante [417] |
| Trans Global Airlines | California | | | | | Long Beach | 1957 | 1961 | Founded by Donald Rich [418] |
| Trans Global Airlines | New Jersey | | | | | Newark Liberty | 1979 | 1984 | Charter carrier [419] |
| Trans Global Vacations | | | | | | | 2002 | 2003 | [420] |
| Trans International Airlines | California | | TV | | TRANSAMERICA | Oakland | 1960 | 1986 | Formed as Los Angeles Air Service (1946), rebranded as Transamerica Airlines |
| Trans International Express | | | | BAP | BIG APPLE | | 1998 | 2002 | [421] |
| Trans Island Airways | Florida | | GO | TRA | TRANS ISLAND | Fort Lauderdale–Hollywood | 1977 | 1982 | Sold and renamed to Trans Air [422] |
| Trans Magic Airlines | Idaho | | | | | Boise | 1969 | 1974 | Merged into Air Idaho [423] |
| Trans National Airlines | California | | | | | Oakland | 1973 | 1979 | [424] |
| Trans Ocean Airways | Florida | | | | | Arcadia | 1989 | 1990 | Established as Gulf Air International [425] |
| Trans Penn Airlines | Pennsylvania | | | | | Reedsville | 1971 | 1980 | Operated Piper Navajo [426] |
| Trans Regional Airlines | Texas | | | | | Big Spring | 1975 | 1977 | Founded by Louis Rosembaum. Established as El Paso Transport [427] |
| Trans Sierra Airlines | Arizona | | | TSI | | Tucson | 1970 | 1971 | Founded by Chris Condon and Allan Silliphant. Renamed to Sierra Pacific Airlines [428] |
| Trans Southern Airways | South Carolina | | | | | Florence | 1976 | 1985 | Established as Pee Dee Air Express Inc. [429] |
| Trans Southern Aieways | Georgia | | | | | | 1984 | 1985 | Routes that had been dropped by Piedmont Airlines [430] |
| Trans States Airlines | Missouri | | AX | LOF | WATERSKI | Chicago–O'Hare Denver | 1989 | 2020 | Shutdown due to travel disruptions caused by the COVID-19 pandemic |
| Trans Tropic Airlines | Florida | | | | | Miami | | | |
| Trans World Airlines | Missouri | | TW | TWA | TWA | New York Kennedy | 1925 | 2001 | Merged into American Airlines. |
| Trans World Connection | | | New York Kennedy Los Angeles | | |
| Trans World Express | | RZ | Philadelphia Northeast | 1987 | 1995 | |
| Trans-Air-Link | Florida | | | GJB | SKY TRUCK | Opa Locka | 1977 | ? | |
| Trans-Cal Airlines | California | | | | | Long Beach | 1968 | 1971 | Operated Beech Queen Air, Beech Bonanza [431] |
| Trans-Central Airlines | Oklahoma | | ZM | ACN | | Oklahoma City | 1980 | 1984 | [432] |
| Trans-Colorado Airlines | Colorado | | VJ | TCE | TRANS COLORADO | Gunnison–Crested Butte | 1980 | 1988 | Became a Continental Express carrier |
| Trans-Florida Airlines | Florida | | | TFA | TRANS FLORIDA | Daytona Beach | 1966 | 2006 | Established as Daytona Aviation in 1962 [433] |
| Trans-Marine Airways | New York | | | | | Daytona Beach | 1945 | 1946 | Charter services [434] |
| Trans-Michigan Airlines | Michigan | | | | | Traverse City | 1969 | 1970 | Operated Beech 99, Cherokee Six [435] |
| Trans-Mo Airlines | Missouri | | XU | | | | 1966 | 1986 | |
| Trans-Nebraska Airlines | Nebraska | | | | | | 1971 | 1973 | Founded by Tom Brown. Operated Cessna 402A [436] |
| Trans-Nevada Air Service | Nevada | | | | | Las Vegas McCarran | 1968 | 1971 | Commuter services. Operated Beech C-45 Expeditor [437] |
| Trans-Pacific Airlines | Hawaii | | | | | Honolulu | 1946 | 1950 | Renamed to TPA-The Aloha Airline. Operated C-47 [438] |
| Trans-Texas Airways | Texas | | TT | | | Dallas Fort Worth | 1947 | 1968 | Renamed to Texas International Airlines. Operated DC-3, Convair 240 [439] |
| Transair | New York | | | | | New York-LaGuardia | 1946 | 1946 | [440] |
| Transair Airlines | Florida | | | | | St. Pete–Clearwater | 1946 | 1949 | Operated DC-3, DC-4, Lockheed Super Electra, Lockheed Lodestar [441] |
| Transair Cargo | Florida | | | | | Miami | 1972 | 1977 | Established as Skyways International in 1962 [442] |
| Transair Hawaii | Hawaii | | | | | Honolulu | 1946 | 1948 | Operated C-46 [13] |
| Transamerica Airlines | California | | TV | TVA | TRANS-AMERICA | Oakland | 1979 | 1986 | Established in 1948 as Los Angeles Air Services |
| Transcontinental & Western Air | New York | | | | | New York-LaGuardia | 1930 | 1950 | Became TWA, Operated DC-1, DC-2 [443] |
| Transcontinental Air Transport | | | | | | | 1928 | 1929 | Merged with Maddux Air Lines |
| TransMeridian Airlines | Georgia | | T9 | TRZ | TRANS MERIDIAN | Orlando Sanford | 1995 | 2005 | Established as Prime Air |
| Transocean Air Lines | California | | TL | | TALOA | Oakland | 1946 | 1960 | Went bankrupt [444] |
| TransOcean Airways | Louisiana | | QG | GAT | GULFTRANS | New Iberia | 1989 | 1990 | Established as Gulf Air Transport. Charter operator |
| Transtar Airlines | Florida | | | TRH | TRANSTAR | Orlando | 1992 | 1993 | [445] |
| TranStar Airlines | Texas | | MC | TST | TRANSTAR | Houston-Hobby | 1986 | 1987 | Shut down by parent company Southwest Airlines |
| Transtate Airlines | New York | | | | | New York-LaGuardia | 1963 | n/a | Operated Lockheed L-1049 [446] |
| Transwest Air Express | California | | | ACW | | Oakland | 1977 | 1981 | Established as Zoom Zoom Air in 1973. Renamed to Air Charter West. Operated DC-3 [447] |
| Transwestern Airlines | Utah | | WZ | TRW | TRANS WEST | Logan-Cache | 1977 | 1983 | Acquired by Horizon Air |
| Travel Air Aviation | | | | | | | 1969 | 1972 | As part of Allegheny Commuter. Operated Beech 99 [448] |
| Tri-Motor Safety Airlines | New York | | | | | Garden City | 1929 | 1929 | Rename to New York Safety Airlines. Operated Ford Trimotor (NC1780) [449] |
| Tri-State Airlines | Iowa | | | | | Rickenbacker | 1930 | 1936 | Renamed to Hanford Tri-State Airlines [450] |
| Tri-State Flying Service | West Virginia | | | | | Huntington Tri-State | 1971 | 1972 | Established as Air Enterprises in 1969 [451] |
| Tricon International Airlines | Texas | | RI | | | Dallas Love Field | 1967 | 1978 | Operated Beech 18, DC-3 [452] |
| Trinity Air Bahamas | Florida | | | | | Fort Lauderdale–Hollywood | 1993 | 1993 | [453] |
| TriStar Airlines | Nevada | | T3 | TRY | TRISTAR AIR | Las Vegas McCarran | 1995 | 1997 | |
| Tropic Air | Hawaii | | | | | Honolulu | 1980 | 1989 | Associated with Air Molokai [454] |
| Tropic Air | California | | | | | Burbank | 1988 | 1988 | [455] |
| Tropical Airways | New York | | | | | New York Kennedy | 1986 | 1989 | [456] |
| Tropics International | Florida | | | | | Miami | 1968 | 1971 | Operated Beech 18 [457] |
| Trump Shuttle | New York | | TB | TPS | TRUMP | New York-LaGuardia | 1989 | 1992 | To US Airways Shuttle |
| Tulip City Executive Express | Minnesota | | | | | Holland | 1995 | 1995 | Operated Beech 18 [458] |
| Tulsa-Oklahoma City Airline | Oklahoma | | | | | Tulsa | 1928 | 1929 | Ownership transferred to Universal Aviation Corporation [459] |
| Turbo Air | Idaho | | | | | Boise | 1995 | 1995 | Charter carrier [460] |
| Turks Air Cargo | Florida | | | | | Miami | 1972 | 2015 | Founded by Robert Caravan [461] |
| Turner Airlines | Indiana | | | | | Indianapolis | 1947 | 1950 | Renamed to Lake Central Airlines [462] |
| Twentieth Century Airlines | North Carolina | | | | | Charlotte Douglas | 1946 | 1963 | Founded by Glen Shave and Christopher Bachman. Operated DC-3, DC-4. To North American Airlines [463] |
| Tyee Airlines | Alaska | | OF | | | Ketchikan | 1975 | 1986 | Operated DHC Beaver [464] |
| Tyme Airlines | Ohio | | | | | Cleveland Burke | 1965 | 1967 | Merged into Wright Airlines [465] |
| U |
| U Fly Air Freighters | Texas | | | | | Dallas Fort Worth | 1973 | 1975 | Cargo operator [466] |
| U.S. Airlines | New York | | | | | New York-LaGuardia | 1945 | 1952 | Non-scheduled services [467] |
| U.S. Aviation | Wyoming | | BH | | | Riverton | 1977 | 1979 | Renamed to Air U.S. [468] |
| UltrAir | New York | | | ULT | ULTRAIR | New York Kennedy | 1993 | 1994 | [469] |
| UltrAir | Texas | | RL | ULT | | Houston Bush | 1993 | 1994 | Operated 727-200 [470] |
| Unalakleet Air Taxi | Alaska | | | | | Unalakleet | 1953 | 1979 | Renamed to Ryan Air [471] |
| United Couriers | California | | | | | Burbank | 1971 | 1971 | Merged with California Air Charter [472] |
| United Feeder Service | Illinois | | U2 | UFS | FEEDER EXPRESS | Chicago O'Hare | 1993 | 2000 | [473] |
| United Shuttle | California | | UA | UAL | UNITED | San Francisco | 1994 | 2001 | Subsidiary of United Airlines, formerly Shuttle by United |
| United States Air Transport | New York | | | | | New York Curtis | 1929 | 1930 | Operated Ryan Brougham [13] |
| United States Overseas Airlines | New Jersey | | | | | Cape May | 1946 | 1964 | Carrier operating primarily for the US Military [474] |
| United Union Airways | Washington | | | | | Felts Field | 1929 | 1929 | Founded by W R Frentzel, C M Baker & Francis Baker [475] |
| Universal Air Lines Corporation | Missouri | | | | | St. Louis Lambert | 1928 | 1934 | To American Airlines |
| Universal Airlines | Michigan | | UV | UTQ | | Willow Run | 1966 | 1972 | Established as Zantop Air Transport. To Saturn Airways |
| Universal Airlines | Michigan | | | | | Willow Run | 1990 | 1992 | Cargo operator [476] |
| Universal Aviation Corporation | Missouri | | | | | | 1929 | | An airline holding company |
| Upper Valley Aviation | Texas | | | | | McAllen Miller | 1964 | 1975 | Operated Beech 99, Beech E18S [477] |
| Uraba, Medellin & Central Airways | New York | | | | | New York-LaGuardia | 1955 | n/a | [13] |
| US Aircoach Airlines | California | | | | | Hollywood Burbank | 1949 | 1956 | Founded by Louis Powell and Wyman Reynolds [478] |
| US Airways | Arizona | | US | USA | US AIR | Phoenix Sky Harbor | 1997 | 2015 | Founded as All American Aviation (1937), renamed All American Airways (1949), renamed Allegheny Airlines (1953), renamed USAir (1979), merged into American Airlines |
| US Airways Express | | Phoenix Sky Harbor | 1967 | Merged with American Eagle |
| US Airways Shuttle | Virginia | | Washington National | 1961 | Founded as Eastern Air Lines Shuttle, merged with American Eagle |
| US Check Airlines | Ohio | | | | | | 1974 | 1974 | Delivery of documents and small packages [479] |
| US Helicopter | New York | | UH | USH | US HELI | Downtown Manhattan Heliport | 2004 | 2009 | |
| USA3000 Airlines | Pennsylvania | | US | GWY | GETAWAY | Philadelphia | 2001 | 2012 | |
| USAfrica Airways | Virginia | | | | | Washington Dulles | 1994 | 1995 | |
| USAir | Arizona | | | | | Phoenix Sky Harbor | 1979 | 1997 | Established as All American Aviation (1937). Renamed to: All American Airways (1949), Allegheny Airlines (1953), USAir (1979), US Airways (1997) |
| Utah Pacific Airways | Utah | | | | | Ogden | 1931 | n/a | [13] |
| Uvalde Aero Service | Texas | | | | | Uvalde | 1965 | 1977 | Operated Lockheed L-12 Electra Junior, Piper Navajo, Piper Twin Comanche [480] |
| V |
| Vagabond Air Travel Club | Ohio | | | | | | 1970 | 1974 | Operated DC-6B, L-188 Electra [481] |
| Vail Airways | Colorado | | | | | | 1966 | 1968 | Founded by Gordon Autry [482] |
| Val-Air Lines | Texas | | | | | Mercedes | 1950 | n/a | Feeder service. Operated Beech Bonanza, Ryan Navion [13] |
| Valdez Airlines | Alaska | | | | | Anchorage | 1980 | 1984 | Merged with Air North to form Liberty Air [483] |
| Valdosta Phoenix Airlines | Georgia | | | | | Valdosta | 1972 | 1973 | [484] |
| Vale International Airlines | Tennessee | | | VIN | | Nashville | 1979 | 1980 | [485] |
| Valley Airlines | California | | | | | Oakland | 1968 | 1974 | Merged with Ram Airways to form Pacific Northwest Airways [486] |
| Valley Airlines | Maine | | | | | Fort Kent | 1981 | 1989 | Renamed to Northeast Express [487] |
| Valley Airpark Commuter Service | Colorado | | | | | Denver | 1975 | 1977 | [488] |
| Valley Catalina Airlines | California | | | | | Van Nuys | 1981 | 1981 | [489] |
| Valley Isle Aviation | Hawaii | | | | | Kahului | 1965 | 1967 | [490] |
| ValuJet Airlines | Georgia | | J7 | VJA | CRITTER | Atlanta | 1993 | 1997 | Merged into AirTran Airways |
| Vance Air Services | Montana | | | | | Great Falls | 1928 | n/a | Founded by Clare Vance. Operated Stinson Detroiter [13] |
| Vance International Airways | Washington | | | | | Boeing Field | 1949 | 1970 | Became McCulloch International Airlines |
| Vanguard Airlines | Missouri | | NJ | VGD | VANGUARD AIR | Kansas City | 1994 | 2002 | Low cost /low fare airline |
| Varney Air Lines | Idaho | | | | | Salt Lake City | 1926 | 1934 | Merged into United Airlines |
| Vee Neal Airlines | Pennsylvania | | | | | Latrobe | 1980 | 1983 | renamed to Jetstream International Airlines [491] |
| Vercoa Air Service | Illinois | | | | | Danville | 1964 | 1975 | Renamed to Britt Airways [492] |
| Vero Monmouth Airlines | Georgia | | VM | VMA | VERO MAMMOUTH | Vero Beach | 1973 | 1975 | Operated de Havilland Heron, Martin 4-0-4 [493] |
| Veterans Air Lines | New Jersey | | | | | Newark | 1945 | n/a | Operated DC-3, DC-4 [494] |
| Via Airlines | Florida | | VC | SRY | | Orlando | 2015 | 2019 | Established as Charter Air Transport. Operated Embraer Brasilia, Embraer ERJ 145 [495] |
| Viair | New jersey | | | | | Newark | 1935 | 1935 | Charter and resort air service [496] |
| ViaAir | Florida | | VC | SRY | STINGRAY | Beckley Raleigh County | 1997 | 2019 | Went bankrupt |
| Victory Aviation Services International | New York | | | | | New York-LaGuardia | 1995 | 1999 | [497] |
| Viking Air Lines | California | | | | | Hollywood Burbank | 1945 | 1949 | Established as Aero-Van Express [498] |
| Viking International Airlines | Minnesota | | VO | VIK | VIKING | Minneapolis–Saint Paul | 1969 | 1994 | Acquired by Eagle Air International [499] |
| Vintage Airways | Florida | | | | | Kissimmee | 1992 | 1995 | Founded by Richard Branson operated in 1940s livery [500] |
| Vintage Props and Jets | Florida | | VQ | VPP | VINTAGE | New Smyrna Beach | 1992 | 2008 | Went bankrupt |
| Virgin America | California | | VX | VRD | REDWOOD | San Francisco | 2004 | 2018 | Acquired by Alaska Airlines |
| Virgin Islands Seaplane Shuttle | US Virgin Islands | | | VSS | WATERBIRD | Saint Croix | 1982 | 1989 | [501] |
| Virginia Air Cargo | Maryland | | | | | Baltimore–Washington | 1974 | 1979 | Operated BN islander, Short Skyvan [502] |
| Visco Flying Service | California | | | | | Los Angeles | 1964 | 1967 | Operated shuttle service. Renamed to Imperial Airlines [503] |
| Viscount Air Service | Arizona | | | VCT | VISCOUNT AIR | Tucson | 1992 | 1996 | Operated B-727, B-737 |
| Vision Airlines | Nevada | | V2 | RBY | RUBY | North Las Vegas | 1994 | 2017 | Established as Vision Air. Incorporated in Virginia. Revoked by State |
| VQ Airlines | Florida | | | | | Daytona Beach | 1970 | 1973 | Airline division of Volusia Aviation Service [504] |
| Vroman Aviation | Texas | | | | | | 1965 | 1972 | Established as Champs Aviation [505] |
| W |
| Walatka Air Service | Alaska | | | | | | 1930 | 1930 | [506] |
| Walker's International | Florida | | XW | WRC | | Fort Lauderdale | 1982 | 2003 | Established as Jet Hansa Corporation in 1967 [507] |
| Warsaw Aviation | Indiana | | | | | Warsaw | 1971 | 1971 | Third-level services. Operated Piper Twin Comanche, Piper Apache [508] |
| Waterman Airlines | Alabama | | | | | Mobile | 1946 | 1948 | Operated Lockheed Lodestar, DC-3 [509] |
| Washington Airlines | Maryland | | | | | Baltimore–Washington | 1968 | 1969 | STOL operation [510] |
| Washington Flying Service | Virginia | | | | | Washington | 1928 | 1929 | Scenic flights [511] |
| Washington-Baltimore Airways | Maryland | | | | | Baltimore–Washington | 1961 | 1971 | Operated Beech 18, Piper Apache [512] |
| Watermakers Air | Florida | | | | | Fort Lauderdale | 1999 | 2018 | Operated Cessna Grand Caravan [513] |
| Waterman Airlines | Alabama | | | | | | 1945 | 1947 | Intrastate carrier [514] |
| Watertown Airways | South Dakota | | | | | Watertown | 1935 | 1936 | [13] |
| Webber Airlines | Alaska | | | | | Ketchikan Harbor Seaplane Base | 1970 | 1979 | Founded by Jim Webber. Merged with Flair Air to form Southeast Alaska Airlines. Operated DHC Beaver], Grumman Goose [515] |
| Wedekind-Schmidlapp Flying Service | Ohio | | | | | Hook Field | 1932 | 1961 | Founded by Larry Schmidlapp and George "Pappy" Wedekind. Operated Waco VKS-7 [516] |
| Wedell-Williams Air Service Corporation | Louisiana | | | | | Patterson | 1929 | 1936 | Founded by Jimmy Wedell and Harry Palmerston Williams. Acquired by Eastern Air Lines. Operated Lockheed Vega 5B [517] |
| Wes-Tex Aircraft | Texas | | | | | Lubbock Airport | 1964 | 1971 | Operated Piper Navajo, Piper Twin Comanche, Piper Cherokee [518] |
| West Central Airlines | Nebraska | | | | | Omaha | 1966 | 1971 | Operated de Havilland Dove, Cherokee Six, Cessna 182 [519] |
| West Coast Air Cargo | Oregon | | | WCC | WEST COAST | Portland–Troutdale | 1982 | 1999 | Cargo carrier [520] |
| West Coast Airlines | Washington | | WC | | | Seattle–Tacoma | 1941 | 1968 | Merged with Pacific Air Lines and Bonanza Air Lines to form Air West which was then renamed Hughes Airwest in 1970 |
| WestAir Airlines | California | | | | | Fresno Yosemite | 1978 | 1986 | Established as Stol Air Commuter. Renamed to WestAir Commuter Airlines [521] |
| WestAir Commuter Airlines | California | | OE | SDU | SUNDANCE | Fresno Yosemite | 1978 | 1992 | Formerly Stol Air Commuter, to Mesa Air Group |
| Westair Transport | California | | | | | | 1947 | 1960 | [522] |
| Westates Airlines | California New Jersey | | WS | WSA | WESTATES | Los Angeles Atlantic City | 1984 | 1995 | Renamed to Gray Line Air [523] |
| Western Air Express | California | | | | | Los Angeles | 1926 | 1930 | Operated Douglas M-2, Fokker F-10 [524] |
| Western Air Express Texas | Texas | | | | | Midland | 2004 | 2016 | Operated Beech Queen Air 70 [525] |
| Western Air Industries | California | | | | | Redding | 1960 | 1960 | Aerial firefighting carrier. Renamed to Aero Union. Operated B-25 Mitchell [526] |
| Western Air Service | Nebraska | | | | | Eppley Airfield | 1930 | 1930 | Operated Ford Trimotor [13] |
| Western Air Stages | Colorado | | | | | Grand Junction | 1972 | 1976 | Operated Beech Queen Air, Riley Dove 400 [527] |
| Western Aircraft | Idaho | | | | | Gooding | 1964 | 1971 | Operated Beech 18, Piper Apache [528] |
| Western Aircraft Salvage | California | | | | | Santa Maria | 1974 | 1980 | Operated Beech 18, Piper Apache [529] |
| Western Airlines | California | | WA | WAL | WESTERN | Los Angeles | 1941 | 1987 | Merged into Delta Air Lines |
| Western Airlines (2007) | Washington | | XP | CXP | RUBY MOUNTAIN | Bellingham | 2007 | 2007 | |
| Western Alaska Airlines | Alaska | | | | | Kodiak | 1940 | 1973 | Merged with Kodiak Airways to form Kodiak Western Alaska [530] |
| Western Express Air | Arizona | | | | | Laughlin/Bullhead | | 2007 | |
| Western Pacific Airlines | Colorado | | W7 | KMR | KOMSTAR | Colorado Springs | 1995 | 1998 | |
| Westflight Aviation | Alaska | | | | | Ketchikan | 1981 | 1986 | Acquired by Temsco Airlines [531] |
| WestJet Express | Nevada | | | | | Fresno Yosemite | 1998 | 1999 | Renamed to Allegiant Air [532] |
| Westward Airways | Nebraska | | CN | WWD | WESTWARD | Western Nebraska | 2004 | 2005 | |
| Wheeler Airlines | North Carolina | | | | | Raleigh–Durham | 1969 | 1991 | Established as Wheeler Flying Service [533] |
| Whidbey Flying Service | Washington | | | | | Oak Harbor | 1964 | 1969 | Founded by Wes Luipen. To Puget Sound Airlines [534] |
| Wien | Alaska | | | | | Anchorage | 1982 | 1984 | [535] |
| Wien Air Alaska | | WC | WAA | | 1973 | 1982 | Several name changes over the years, final name Wien [536] |
| Wien Airways of Alaska | | | | | 1926 | 1935 | Established as Northern Air Transport [537] |
| Wien Alaska Airways | | | | | 1935 | 1968 | Merged with Northern Consolidated Airlines to form Wien Consolidated Airlines [538] |
| Wien Consolidated Airlines | | | | | 1968 | 1973 | Formed by the merger of Wien Alaska Airlines and Northern Consolidated Airlines [539] |
| Wilbur’s Inc. | Alaska | | | | | Anchorage | 1984 | 1992 | [540] |
| Wild Goose Flying Service | Texas | | | | | San Antonio | 1984 | 1992 | [541] |
| Wildblue Yonder-Aero Taxi | Idaho | | | | | Lemhi County | 1998 | 1998 | [542] |
| Williams Air | New Jersey | | | | | | 1981 | 1983 | Operated BN Islander [543] |
| Wilmington Catalina Airlines | California | | | | | Catalina | 1931 | 1941 | [544] |
| WinAir Airlines | Utah | | | WNA | WINAIR | Salt Lake City | 1997 | 1999 | |
| Winged Cargo Company | Pennsylvania | | | | | Northeast Philadelphia | 1931 | 1946 | Freight service. Operated DC-3 towing Waco CG-4 [545] |
| Wings Air | Georgia | | | WAI | | Atlanta | 2008 | 2010 | [546] |
| Wings Airways | Pennsylvania | | WQ | WAW | WING SHUTTLE | Blue Bell Wings Field | 1977 | 1991 | |
| Wings Express | California | | | | | Burbank | 1993 | 1993 | Cargo carrier. Acquired by Ameriflight [547] |
| Wings of Alaska | Alaska | | K5 | SQH | SASQUACH | Juneau | 1982 | 2017 | Founded by Dean Williams and Billy Bernhardt. Established as Southeast Skyways. Operated Cessna 207, DHC-3 Otter |
| Wings West Airlines | California | | RM | WWM | WINGS WEST | McChesney Field | 1979 | 1998 | Later operated as American Eagle, then merged into Simmons Airlines |
| Winkys Fish Airlines | Alaska | | | | | Anchorage | 1990 | 1990 | Operated Boeing 727. Salmon transport [548] |
| Winnipesaukee Airlines | Florida | | | | | Tampa | 1976 | 1977 | [549] |
| Wisconsin Central Airlines | Wisconsin | | | | | Clintonville | 1946 | 1952 | Renamed to North Central Airlines [550] |
| Wise Airlines | Texas | | 4W | | | San Angelo | 1983 | 1985 | Operated Beech 99, Twin Otter. Went bankrupt [551] |
| Woodley Airways | Alaska | | | | | Merrill Field | 1932 | 1945 | Renamed to Pacific Northern Airlines [552] |
| Woods Air Service | Alaska | | | | | Palmer | 1961 | 2000 | [553] |
| World Airways | Georgia | | WO | WOA | WORLD | Atlanta | 1948 | 2014 | |
| World American Airlift | California | | | | | Fresno Yosemite | 1968 | 1970 | [554] |
| World Wide Airlines | Alaska | | | | | Anchorage | 1956 | 1962 | Established as Pearson-Alaska Airlines in 1948. Operated DC-4, C-46, L-749, L-1049 [555] |
| Worldwide Airlines | Illinois | | | | | Chicago Midway | 1983 | 1986 | Subsidiary of Carefree Vacations Inc. [556] |
| Wrangler Aviation | North Carolina | | | | | Piedmont Triad | 1973 | 1991 | Established as Bluebell Aviation in 1969. Renamed to Tradewinds Airlines [557] |
| Wright Airlines | Ohio | | FW | WRT | WRIGHT | Cleveland Burke | 1966 | 1983 | Went bankrupt |
| WTC Air Freight | New Jersey | | | | | | 1967 | 1987 | Acquired by BAX Global [558] [559] |
| Wyoming Air Service | Wyoming | | | | | Cheyenne | 1930 | 1937 | Renamed to Inland Air Lines. Operated Stinson Junior, Boeing 247D [560] |
| Wyoming-Montana Air Lines | Wyoming | | | | | Casper–Natrona | 1930 | 1938 | Renamed to Inland Air Lines in 1938 [561] |
| X |
| Y |
| Yankee Airlines | Massachusetts | | | | | Pittsfield | 1962 | 1968 | Acquired by Executive Airlines. Operated de Havilland Dove [562] |
| Yosemite Airlines | California | | JE | | | Columbia | 1975 | 1981 | [563] |
| Yukon Air Service | Alaska | | | | | Fairbanks | 1967 | 1973 | Founded by Roger Dowding. Renamed to Air North [564] |
| Yutana Airlines | Alaska | | | | | Anchorage | 1987 | 1994 | Renamed to Alaska Central Express [565] |
| Yute Air | Alaska | | 4Y | UYA | | Bethel | 2004 | 2017 | [566] |
| Yute Air Alaska | Alaska | | | | | Bethel | 1974 | 2000 | Established as Bob Harris Flying Service. Renamed to Flight Alaska [567] |
| Z |
| Zantop Air Transport | Michigan | | | | | Willow Run | 1962 | 1966 | To Universal Airlines |
| Zantop Flying Service | Michigan | | | | | Willow Run | 1946 | 1962 | Became Zantop Air Transport |
| Zantop International Airlines | Michigan | | VK | ZAN | ZANTOP | Willow Run | 1972 | 2005 | |
| Zetta Jet | California | | | | | Burbank | 2015 | 2017 | Established as Advanced Air Management [568] |
| Zia Airlines | New Mexico | | | | | Las Cruces | 1972 | 1980 | Renamed to Air New Mexico. Air ambulance services [569] |
| Zimmerly Air Lines | Idaho | | | | | Boise | 1942 | 1946 | Renamed Empires Airlines [570] |
| Zoom Zoom Air | California | | | | | Oakland | 1973 | 1974 | Renamed to Air Charter West. Operated Basler BT-67 [571] |