Melanotransferrin

MELTF
Identifiers
Aliases	MELTF , CD228, MAP97, MTF1, MTf, MFI2, melanotransferrin
External IDs	OMIM: 155750 MGI: 1353421 HomoloGene: 4335 GeneCards: MELTF
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q29 Start 196,980,590 bp [1] End 197,029,835 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16|16 B2 Start 31,697,628 bp [2] End 31,717,838 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia parotid gland renal medulla parietal pleura endothelial cell amniotic fluid germinal epithelium sperm seminal vesicula nipple Top expressed in stria vascularis trachea utricle intercostal muscle ankle joint condyle fossa sexually immature organism ileum yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function iron ion binding protein binding metal ion binding Cellular component cell surface anchored component of plasma membrane anchored component of membrane integral component of plasma membrane extracellular exosome membrane extracellular region extracellular space plasma membrane endoplasmic reticulum lumen Biological process positive regulation of extracellular matrix disassembly iron ion homeostasis negative regulation of substrate adhesion-dependent cell spreading regulation of cell population proliferation positive regulation of plasminogen activation ion transport regulation of cell growth C-terminal protein lipidation post-translational protein modification transport iron ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4241 30060 Ensembl ENSG00000163975 ENSMUSG00000022780 UniProt P08582 Q9R0R1 RefSeq (mRNA) NM_005929 NM_033316 NM_013900 RefSeq (protein) NP_005920 NP_201573 NP_038928 Location (UCSC) Chr 3: 196.98 – 197.03 Mb Chr 16: 31.7 – 31.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Melanotransferrin is a protein that in humans is encoded by the MFI2 gene. MFI2 has also recently been designated CD228 (cluster of differentiation 228).

The protein encoded by this gene is a cell-surface glycoprotein found on melanoma cells. The protein shares sequence similarity and iron-binding properties with members of the transferrin superfamily. The importance of the iron binding function has not yet been identified. This gene resides in the same region of chromosome 3 as members of the transferrin superfamily. Alternative splicing results in two transcript variants. ^[5] It is part of neural crest tissue, often present in melanotic neuroectodermal tumor of infancy.

References

1. GRCh38: Ensembl release 89: ENSG00000163975 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022780 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5".

Further reading

• Suryo Rahmanto Y, Dunn LL, Richardson DR (2007). "The melanoma tumor antigen, melanotransferrin (p97): a 25-year hallmark--from iron metabolism to tumorigenesis". Oncogene. 26 (42): 6113–24. doi:10.1038/sj.onc.1210442. PMID   17452986.
• Baker EN, Baker HM, Smith CA, et al. (1992). "Human melanotransferrin (p97) has only one functional iron-binding site". FEBS Lett. 298 (2–3): 215–8. doi:10.1016/0014-5793(92)80060-T. PMID   1544447. S2CID   21022972.
• Garratt RC, Jhotí H (1992). "A molecular model for the tumour-associated antigen, p97, suggests a Zn-binding function". FEBS Lett. 305 (1): 55–61. doi: 10.1016/0014-5793(92)80654-Y . PMID   1633859. S2CID   23569786.
• Rose TM, Plowman GD, Teplow DB, et al. (1986). "Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence" (PDF). Proc. Natl. Acad. Sci. U.S.A. 83 (5): 1261–5. Bibcode:1986PNAS...83.1261R. doi: 10.1073/pnas.83.5.1261 . PMC   323055 . PMID   2419904.
• Furukawa KS, Furukawa K, Real FX, et al. (1989). "A unique antigenic epitope of human melanoma is carried on the common melanoma glycoprotein gp95/p97". J. Exp. Med. 169 (2): 585–90. doi:10.1084/jem.169.2.585. PMC   2189208 . PMID   2463331.
• Sciot R, de Vos R, van Eyken P, et al. (1989). "In situ localization of melanotransferrin (melanoma-associated antigen P97) in human liver. A light- and electronmicroscopic immunohistochemical study". Liver. 9 (2): 110–9. doi:10.1111/j.1600-0676.1989.tb00387.x. PMID   2540389.
• Seligman PA, Butler CD, Massey EJ, et al. (1986). "The p97 antigen is mapped to the q24-qter region of chromosome 3; the same region as the transferrin receptor". Am. J. Hum. Genet. 38 (4): 540–8. PMC   1684788 . PMID   3010712.
• Le Beau MM, Diaz MO, Plowman GD, et al. (1986). "Chromosomal sublocalization of the human p97 melanoma antigen". Hum. Genet. 72 (4): 294–6. doi:10.1007/BF00290951. PMID   3754536. S2CID   38961040.
• Plowman GD, Brown JP, Enns CA, et al. (1983). "Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3". Nature. 303 (5912): 70–2. Bibcode:1983Natur.303...70P. doi:10.1038/303070a0. PMID   6843660. S2CID   4332107.
• Kennard ML, Richardson DR, Gabathuler R, et al. (1995). "A novel iron uptake mechanism mediated by GPI-anchored human p97". EMBO J. 14 (17): 4178–86. doi:10.1002/j.1460-2075.1995.tb00091.x. PMC   394500 . PMID   7556058.
• Food MR, Rothenberger S, Gabathuler R, et al. (1994). "Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein". J. Biol. Chem. 269 (4): 3034–40. doi: 10.1016/S0021-9258(17)42043-6 . PMID   8300636.
• Rothenberger S, Food MR, Gabathuler R, et al. (1996). "Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium". Brain Res. 712 (1): 117–21. doi:10.1016/0006-8993(96)88505-2. PMID   8705293. S2CID   45470799.
• Chi DD, Merchant RE, Rand R, et al. (1997). "Molecular detection of tumor-associated antigens shared by human cutaneous melanomas and gliomas". Am. J. Pathol. 150 (6): 2143–52. PMC   1858329 . PMID   9176405.
• Richardson DR (2000). "The role of the membrane-bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell". Eur. J. Biochem. 267 (5): 1290–8. doi:10.1046/j.1432-1327.2000.01079.x. PMID   10691965.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and characterization of the potential promoter regions of 1031 kinds of human genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC   311086 . PMID   11337467.
• Sekyere E, Food MR, Richardson DR (2002). "A second melanotransferrin gene (MTf2) and a novel protein isoform: explanation for the membrane-bound and soluble forms of melanotransferrin?". FEBS Lett. 512 (1–3): 350–2. doi:10.1016/S0014-5793(02)02248-2. PMID   11852110. S2CID   38104056.
• Food MR, Sekyere EO, Richardson DR (2002). "The soluble form of the membrane-bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein". Eur. J. Biochem. 269 (18): 4435–45. doi: 10.1046/j.1432-1033.2002.03140.x . PMID   12230555.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Guo J, Wen DR, Huang RR, et al. (2003). "Detection of multiple melanoma-associated markers in melanoma cell lines by RT in situ PCR". Exp. Mol. Pathol. 74 (2): 140–7. doi:10.1016/S0014-4800(03)00012-1. PMID   12710945.

External links

• MFI2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.