TRPP3

PKD2L2
Identifiers
Aliases	PKD2L2 , TRPP5, polycystin 2 like 2, transient receptor potential cation channel
External IDs	OMIM: 604669; MGI: 1858231; HomoloGene: 22812; GeneCards: PKD2L2; OMA:PKD2L2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	137,942,747 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	34,577,169 bp
RNA expression pattern
	Top expressed in
	tendon of biceps brachii; ; buccal mucosa cell; ; testicle; ; left testis; ; right testis; ; sperm; ; internal globus pallidus; ; gonad; ; muscle of thigh; ; Achilles tendon;
	Top expressed in
	zygote; ; primary oocyte; ; secondary oocyte; ; spermatocyte; ; spermatid; ; granulocyte; ; seminiferous tubule; ; egg cell; ; supraoptic nucleus; ; muscle of thigh;
	More reference expression data
	n/a
Gene ontology
Molecular function	calcium ion binding ; calcium channel activity ;
Cellular component	integral component of membrane ; membrane ;
Biological process	ion transport ; detection of mechanical stimulus ; calcium ion transmembrane transport ; biological process ;
	Sources:Amigo / QuickGO
Orthologs
	27039
	53871
	ENSG00000078795
	ENSMUSG00000014503
	Q9NZM6
	Q9JLG4
	NM_001258448 ; NM_001258449 ; NM_001300921 ; NM_014386
	NM_001163004 ; NM_016927
	NP_001245377 ; NP_001245378 ; NP_001287850 ; NP_055201
	NP_001156476 ; NP_058623
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 17, 2024

Polycystic kidney disease 2-like 2 protein (PKD2L2) also known as transient receptor potential polycystic 5 (TRPP5) is a protein that in humans is encoded by the PKD2L2 gene.^[5]

Related Research Articles

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Polycystin 1 (PC1) is a protein that in humans is encoded by the PKD1 gene. Mutations of PKD1 are associated with most cases of autosomal dominant polycystic kidney disease, a severe hereditary disorder of the kidneys characterised by the development of renal cysts and severe kidney dysfunction.

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<span class="mw-page-title-main">Polycystin 2</span> Protein and coding gene in humans

Polycystin-2(PC2) is a protein that in humans is encoded by the PKD2 gene.

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Transducin beta-like protein 3 is a protein that in humans is encoded by the TBL3 gene.

Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by this gene is both a receptor for inositol triphosphate and a calcium channel.

<span class="mw-page-title-main">MCOLN3</span> Protein-coding gene in the species Homo sapiens

Mucolipin-3 also known as TRPML3 is a protein that in humans is encoded by the MCOLN3 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels.

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SEC14 and spectrin domains 1, also known as SEC14 domain and spectrin repeat-containing protein 1 and Solo, is a protein that in humans is encoded by the SESTD1 gene.

Polycystin 1 like 1, transient receptor potential channel interacting is a protein that in humans is encoded by the PKD1L1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi: 10.1038/sj.ejhg.5200383 . PMID 10602361.

Li Q, Liu Y, Zhao W, Chen XZ (2002). "The calcium-binding EF-hand in polycystin-L is not a domain for channel activation and ensuing inactivation". FEBS Lett. 516 (1–3): 270–8. Bibcode:2002FEBSL.516..270L. doi: 10.1016/S0014-5793(02)02513-9 . PMID 11959145. S2CID 1812119.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Stayner C, Zhou J (2001). "Polycystin channels and kidney disease". Trends Pharmacol. Sci. 22 (11): 543–6. doi:10.1016/S0165-6147(00)01832-0. PMID 11698076.
Guo L, Schreiber TH, Weremowicz S, et al. (2000). "Identification and characterization of a novel polycystin family member, polycystin-L2, in mouse and human: sequence, expression, alternative splicing, and chromosomal localization". Genomics. 64 (3): 241–51. doi:10.1006/geno.2000.6131. PMID 10756092.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000078795 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10602361-5] Veldhuisen B, Spruit L, Dauwerse HG, Breuning MH, Peters DJ (December 1999). "Genes homologous to the autosomal dominant polycystic kidney disease genes (PKD1 and PKD2)". Eur. J. Hum. Genet. 7 (8): 860–72. doi: 10.1038/sj.ejhg.5200383 . PMID 10602361.

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TRPP3

Contents

See also

Related Research Articles

References

Further reading