Calmodulin-regulated spectrin-associated protein 3

CAMSAP3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1UGJ
Identifiers
Aliases	CAMSAP3 , KIAA1543, NEZHA, PPP1R80, calmodulin regulated spectrin associated protein family member 3
External IDs	OMIM: 612685; MGI: 1916947; HomoloGene: 18966; GeneCards: CAMSAP3; OMA:CAMSAP3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19p13.2 Start 7,595,863 bp [1] End 7,618,304 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A1.1 Start 3,587,293 bp [2] End 3,609,075 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of abdomen skin of leg mucosa of transverse colon right lobe of liver body of pancreas right hemisphere of cerebellum duodenum right lobe of thyroid gland salivary gland minor salivary glands Top expressed in secondary oocyte lip primary oocyte submandibular gland lacrimal gland zygote epiblast duodenum zone of skin epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function microtubule binding spectrin binding calmodulin binding protein binding actin filament binding microtubule minus-end binding Cellular component cytoplasm zonula adherens adherens junction cell junction centrosome microtubule cytoskeleton microtubule minus-end Biological process negative regulation of phosphatase activity regulation of microtubule cytoskeleton organization microtubule anchoring epithelial cell-cell adhesion neuron projection development zonula adherens maintenance regulation of cell migration regulation of focal adhesion assembly regulation of Golgi organization microtubule cytoskeleton organization embryo development ending in birth or egg hatching establishment or maintenance of microtubule cytoskeleton polarity regulation of microtubule polymerization regulation of organelle organization establishment of epithelial cell apical/basal polarity protein transport along microtubule negative regulation of microtubule depolymerization cytoplasmic microtubule organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57662 69697 Ensembl ENSG00000076826 ENSMUSG00000044433 UniProt Q9P1Y5 Q80VC9 RefSeq (mRNA) NM_001080429 NM_020902 NM_001163749 NM_027171 NM_001347111 NM_001347112 NM_001347113 RefSeq (protein) NP_001073898 NP_065953 NP_001157221 NP_001334040 NP_001334041 NP_001334042 NP_081447 NP_001350168 NP_001350169 NP_001350170 NP_001350171 NP_001350172 NP_001350173 NP_001350174 NP_001350175 NP_001350176 NP_001350177 NP_001350178 Location (UCSC) Chr 19: 7.6 – 7.62 Mb Chr 8: 3.59 – 3.61 Mb PubMed search [3] [4]
Wikidata
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Calmodulin-regulated spectrin-associated protein family member 3 (CAMSAP3) is a human protein encoded by the gene CAMSAP3. The protein is commonly referred to as Nezha.

Function

CAMSAP3 acts as a minus-end anchor of microtubules, and binds to them through its CKK domain. ^[5]

In epithelial cells, it anchors microtubules to the apical cortex, causing them to grow in an apical-to-basal direction. ^[6] This gives the epithelial cells their rectangular shape.

In other species

In early mouse embryogenesis, the interphase bridge linking sister cells is enriched with CAMSAP3. ^[7]

See also

• CAMSAP1
• CAMSAP2

References

1. GRCh38: Ensembl release 89: ENSG00000076826 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000044433 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Baines, A. J.; Bignone, P. A.; King, M. D.A.; Maggs, A. M.; Bennett, P. M.; Pinder, J. C.; Phillips, G. W. (2009-09-01). "The CKK Domain (DUF1781) Binds Microtubules and Defines the CAMSAP/ssp4 Family of Animal Proteins". Molecular Biology and Evolution. 26 (9): 2005–2014. doi: 10.1093/molbev/msp115 . ISSN   0737-4038. PMID   19508979. Archived from the original on 2022-06-15. Retrieved 2022-09-29.
6. Toya M, Kobayashi S, Kawasaki M, Shioi G, Kaneko M, Ishiuchi T, et al. (January 2016). "CAMSAP3 orients the apical-to-basal polarity of microtubule arrays in epithelial cells". Proceedings of the National Academy of Sciences of the United States of America. 113 (2): 332–337. Bibcode:2016PNAS..113..332T. doi: 10.1073/pnas.1520638113 . PMC   4720291 . PMID   26715742.
7. Zenker J, White MD, Templin RM, Parton RG, Thorn-Seshold O, Bissiere S, Plachta N (September 2017). "A microtubule-organizing center directing intracellular transport in the early mouse embryo". Science. 357 (6354): 925–928. Bibcode:2017Sci...357..925Z. doi: 10.1126/science.aam9335 . PMID   28860385. S2CID   206658036.