Integrin alpha 2

Last updated
ITGA2
Protein ITGA2 PDB 1aox.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITGA2 , BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2, integrin subunit alpha 2
External IDs OMIM: 192974 MGI: 96600 HomoloGene: 1662 GeneCards: ITGA2
Orthologs
SpeciesHumanMouse
Entrez

3673

16398

Ensembl

ENSG00000164171

ENSMUSG00000015533

UniProt

P17301

Q62469

RefSeq (mRNA)

NM_002203

NM_008396

RefSeq (protein)

NP_002194

NP_032422

Location (UCSC) Chr 5: 52.99 – 53.09 Mb Chr 13: 114.97 – 115.07 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-2, or CD49b (cluster of differentiation 49b), is a protein which in humans is encoded by the CD49b gene.

Contents

The CD49b protein is an integrin alpha subunit. It makes up half of the α2β1 integrin duplex. Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They are found on a wide variety of cell types including T cells (the NKT cells), NK cells, fibroblasts and platelets. Integrins are involved in cell adhesion and also participate in cell-surface-mediated signalling. [5]

Expression of CD49b in conjunction with LAG-3 has been used to identify type 1 regulatory (Tr1) cells. [6]

The DX5 monoclonal antibody recognizes mouse CD49b. [7]

Interactions

CD49b has been shown to interact with MMP1. [8] [9]

Related Research Articles

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<span class="mw-page-title-main">Integrin alpha-1</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">Integrin beta 3</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">Integrin alpha 2b</span> Mammalian protein found in Homo sapiens

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

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<span class="mw-page-title-main">Integrin alpha 5</span>

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<span class="mw-page-title-main">Laminin, alpha 5</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">GP1BB</span> Protein-coding gene in the species Homo sapiens

Glycoprotein Ib (platelet), beta polypeptide (GP1BB) also known as CD42c, is a protein that in humans is encoded by the GP1BB gene.

<span class="mw-page-title-main">Collagen, type XIV, alpha 1</span> Protein found in humans

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<span class="mw-page-title-main">GP5 (gene)</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Integrin alpha 9</span> Protein-coding gene in the species Homo sapiens

Integrin alpha-9 is a protein that in humans is encoded by the ITGA9 gene. Cytogenetic location: 3p22.2

<span class="mw-page-title-main">Laminin subunit gamma-3</span> Protein-coding gene in the species Homo sapiens

Laminin subunit gamma-3 also known as LAMC3 is a protein that in humans is encoded by the LAMC3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000164171 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000015533 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ "Entrez Gene: ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)".
  6. ↑ Gagliani N, Magnani CF, Huber S, Gianolini ME, Pala M, Licona-Limon P, Guo B, Herbert DR, Bulfone A (2013-06-01). "Coexpression of CD49b and LAG-3 identifies human and mouse T regulatory type 1 cells". Nature Medicine. 19 (6): 739–746. doi:10.1038/nm.3179. ISSN   1546-170X. PMID   23624599. S2CID   21305032.
  7. ↑ Arase H, Saito T, Phillips JH, Lanier LL (August 2001). "Cutting edge: the mouse NK cell-associated antigen recognized by DX5 monoclonal antibody is CD49b (alpha 2 integrin, very late antigen-2)". Journal of Immunology. 167 (3): 1141–4. doi: 10.4049/jimmunol.167.3.1141 . PMID   11466327.
  8. ↑ Stricker TP, Dumin JA, Dickeson SK, Chung L, Nagase H, Parks WC, Santoro SA (Aug 2001). "Structural analysis of the alpha(2) integrin I domain/procollagenase-1 (matrix metalloproteinase-1) interaction". J. Biol. Chem. 276 (31): 29375–81. doi: 10.1074/jbc.M102217200 . PMID   11359774.
  9. ↑ Dumin JA, Dickeson SK, Stricker TP, Bhattacharyya-Pakrasi M, Roby JD, Santoro SA, Parks WC (Aug 2001). "Pro-collagenase-1 (matrix metalloproteinase-1) binds the alpha(2)beta(1) integrin upon release from keratinocytes migrating on type I collagen". J. Biol. Chem. 276 (31): 29368–74. doi: 10.1074/jbc.M104179200 . PMID   11359786.

Further reading


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