BTS 74,398

BTS 74,398

Identifiers
IUPAC name 1-([1-(3,4-dichlorophenyl)cyclobutyl]-2-(3-diaminethylaminopropylthio)ethanone
CAS Number	548491-50-5
PubChem CID	24838024
ChemSpider	26325181  Y
UNII	I3W0WCC63A
CompTox Dashboard (EPA)	DTXSID801027130
Chemical and physical data
Formula	C19H29Cl2N3OS
Molar mass	418.42 g·mol−1
3D model (JSmol)	Interactive image Interactive image
SMILES NCCN(CCN)CCCSCC(=O)C2(CCC2)c(cc1Cl)ccc1Cl c1cc(c(cc1C2(CCC2)C(=O)CSCCCN(CCN)CCN)Cl)Cl
InChI InChI=1S/C19H29Cl2N3OS/c20-16-4-3-15(13-17(16)21)19(5-1-6-19)18(25)14-26-12-2-9-24(10-7-22)11-8-23/h3-4,13H,1-2,5-12,14,22-23H2 Y Key:OLQJWCYRPYGTJI-UHFFFAOYSA-N Y
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BTS 74,398 is a centrally acting stimulant drug which was developed for the treatment of Parkinson's disease. It inhibits the synaptic reuptake of dopamine, serotonin and noradrenaline, making it a triple reuptake inhibitor. ^[1] It was effective in animal models of Parkinson's disease, ^{[2] [3]} but was unsuccessful in human trials. ^[4]

References

1. Lane EL, Cheetham S, Jenner P (March 2005). "Dopamine uptake inhibitor-induced rotation in 6-hydroxydopamine-lesioned rats involves both D1 and D2 receptors but is modulated through 5-hydroxytryptamine and noradrenaline receptors". The Journal of Pharmacology and Experimental Therapeutics. 312 (3): 1124–31. doi:10.1124/jpet.104.076554. PMID   15542624. S2CID   8208352.
2. Hansard MJ, Smith LA, Jackson MJ, Cheetham SC, Jenner P (January 2004). "The monoamine reuptake inhibitor BTS 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in MPTP-treated primates". Movement Disorders. 19 (1): 15–21. doi:10.1002/mds.10596. PMID   14743355. S2CID   26120965.
3. Lane EL, Cheetham SC, Jenner P (January 2005). "Repeated administration of the monoamine reuptake inhibitor BTS 74 398 induces ipsilateral circling in the 6-hydroxydopamine lesioned rat without sensitizing motor behaviours". The European Journal of Neuroscience. 21 (1): 179–86. doi:10.1111/j.1460-9568.2004.03834.x. PMID   15654855. S2CID   22417785.
4. Lane EL, Cheetham S, Jenner P (2008). "Striatal output markers do not alter in response to circling behaviour in 6-OHDA lesioned rats produced by acute or chronic administration of the monoamine uptake inhibitor BTS 74 398". Journal of Neural Transmission. 115 (3): 423–9. doi:10.1007/s00702-007-0854-x. PMID   18250952. S2CID   195993.