Prazitone

Prazitone

Clinical data
Other names	AGN-511; 5-Phenyl-5-(2-piperidylmethyl)barbituric acid
ATC code	none
Identifiers
IUPAC name 5-phenyl-5-(piperidin-2-ylmethyl)pyrimidine-2,4,6(1H,3H,5H)-trione
CAS Number	2409-26-9  Y
PubChem CID	3050417
ChemSpider	2312482  N
UNII	6DZB018428
CompTox Dashboard (EPA)	DTXSID80862926
Chemical and physical data
Formula	C16H19N3O3
Molar mass	301.346 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CCNC(C1)CC2(C(=O)NC(=O)NC2=O)C3=CC=CC=C3
InChI InChI=1S/C16H19N3O3/c20-13-16(11-6-2-1-3-7-11,14(21)19-15(22)18-13)10-12-8-4-5-9-17-12/h1-3,6-7,12,17H,4-5,8-10H2,(H2,18,19,20,21,22) N Key:UGZAKKMLMJITLL-UHFFFAOYSA-N N
NY  (what is this?)    (verify)

Prazitone (INN Tooltip International Nonproprietary Name, BAN Tooltip British Approved Name; developmental code name AGN-511) is a barbiturate derivative described as an antidepressant which was developed in the 1960s. ^{[1] [2]} Unlike most barbiturates, it has little or no sedative effects, instead acting as a non-sedating anxiolytic and antidepressant. ^{[3] [1]} The dosage range in humans is around 200–600 mg, although higher doses have been used in trials for the treatment of depression associated with Parkinson's disease.^{[ citation needed ]}

References

1. Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 1011. ISBN   978-1-4757-2085-3 . Retrieved 20 October 2024.
2. DE 1645911,Wiggins LF, Gittos MW, James JW,"Process for the preparation of derivatives of barbituric acid",issued 30 May 1973, assigned to Aspro Nicholas Ltd. 
3. US 3806596,Langlands R,"Method for imparting anti-depressant and/or anxiolytic effects to animals.",issued 23 March 1974, assigned to Aspro Nicholas Ltd.