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| Formula | C12H16FNO |
| Molar mass | 209.264 g·mol−1 |
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3-Fluoro-N-ethylbuphedrone (3F-NEB) is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug. It was first identified in Sweden in 2021. [1] [2]
Substituted cathinones, or simply cathinones, which include some stimulants and entactogens, are derivatives of cathinone. They feature a phenethylamine core with an alkyl group attached to the alpha carbon, and a ketone group attached to the beta carbon, along with additional substitutions. Cathinone occurs naturally in the plant khat whose leaves are chewed as a recreational drug.
Benzedrone (4-MBC) is a designer drug which has been found since 2010 as an ingredient in a number of "bath salt" mixes sold as recreational drugs.
Bath salts are a group of recreational designer drugs. The name derives from instances in which the drugs were disguised as bath salts. The white powder, granules, or crystals often resemble Epsom salts, but differ chemically. The drugs' packaging often states "not for human consumption" in an attempt to circumvent drug prohibition laws. Additionally, they may be described as "plant food", "powdered cleaner", or other products.
N-Ethylhexedrone (also known as α-ethylaminocaprophenone, N-ethylnorhexedrone, hexen, and NEH) is a stimulant of the cathinone class that acts as a norepinephrine–dopamine reuptake inhibitor (NDRI) with IC50 values of 0.0978 and 0.0467 μM, respectively. N-Ethylhexedrone was first mentioned in a series of patents by Boehringer Ingelheim in the 1960s which led to the development of the better-known drug methylenedioxypyrovalerone (MDPV). Since the mid-2010s, N-ethylhexedrone has been sold online as a designer drug. In 2018, N-ethylhexedrone was the second most common drug of the cathinone class to be identified in Drug Enforcement Administration seizures.
5-Methylmethiopropamine is a stimulant drug which is a ring-substituted derivative of methiopropamine. It is not a substituted cathinone derivative like mephedrone, as it lacks a ketone group at the β position of the aliphatic side chain, but instead more closely resembles substituted amphetamines. It has been sold as a designer drug, first being identified in Germany in June 2020.
Dipyanone is an opioid analgesic which has been sold as a designer drug, first identified in Germany in 2021. It is closely related to medically used drugs such as methadone, dipipanone and phenadoxone, but is slightly less potent.
3F-PiHP (3F-α-PiHP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in both Sweden and Finland in mid-2019, and was made illegal in Finland in August 2019.
4-Ethyl-alpha-Pyrrolidinovalerophenone (4-Et-PVP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Hungary in March 2019.
3F-NEH (3-Fluoro-N-Ethylhexedrone) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Sweden in October 2020.
N-Ethylhexylone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Poland in August 2019. It is illegal in Taiwan since July 2020, where it had been sold mixed with plant material under the name 彩虹菸.
MFPVP (3-Methyl-4-fluoro-α-pyrrolidinovalerophenone) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It was first identified in Sweden in April 2020 and was among the most widely encountered substituted cathinone derivatives in 2021, though it since appears to have declined in prevalence. It is illegal in Virginia.
N-Ethylheptedrone is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethcathinone, N-ethylbuphedrone and N-ethylhexedrone but with a longer pentyl side chain. It was first identified in Hungary in 2019, and has since been reported in New Zealand.
N-Ethylheptylone (HEP) is a recreational designer drug from the substituted cathinone family, with stimulant effects. It is a homologue of related drugs such as ethylone, eutylone, ephylone and N-ethylhexylone but with a longer pentyl side chain. It was first reported in Sweden in 2019.
4-Chloro-3-Methylmethcathinone (4-Cl-3-MMC) is a chemical compound from the substituted cathinone family. It has stimulant effects, and has been sold as a designer drug. It was first identified in Sweden in 2021. It is illegal in Italy and Finland, as well as under generic legislation in various other jurisdictions.
4-HO-MALT (4-hydroxy-N-methyl-N-allyltryptamine) is a tryptamine derivative which has been sold as a designer drug, first being detected in Slovenia in 2021.
2-Methyl-alpha-PVP (2-Me-PVP) is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug. It was first identified in Sweden in 2021.
3-Methylmethamphetamine (3-MMA) or Metaphedrine is an amphetamine derivative which has been sold as a designer drug, first being reported in Sweden in 2021.
Deschloroclotizolam is a thienotriazolodiazepine derivative which has been sold as a designer drug, first being identified in Sweden in 2021.
3-Fluoro-alpha-PHP (3F-PHP) is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug. It was first identified in Sweden in 2020 and continues to be detected in seized drug samples, though it appears to have been less widely used than related compounds such as 3F-PVP and 3F-PiHP.
MDPEP is a substituted cathinone derivative with stimulant effects which has been sold as a designer drug. It is the longer chain heptyl homologue of the well known stimulant designer drugs MDPV and MDPHP. It was first identified in Sweden in 2019 and has been relatively widely sold, being the most commonly encountered substituted cathinone derivative found in the US in 2020–2021, though it has still not reached the same levels of use internationally as MDPV and MDPHP.
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