CD82 (gene)

Last updated

CD82
Identifiers
Aliases CD82 , 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27, CD82 molecule
External IDs OMIM: 600623; MGI: 104651; HomoloGene: 20512; GeneCards: CD82; OMA:CD82 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3732

12521

Ensembl

ENSG00000085117

ENSMUSG00000027215

UniProt

P27701

P40237

RefSeq (mRNA)

NM_001024844
NM_002231

RefSeq (protein)

NP_001020015
NP_002222

Location (UCSC) Chr 11: 44.56 – 44.62 Mb Chr 2: 93.25 – 93.29 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

CD82 (Cluster of Differentiation 82), or KAI1, is a human protein encoded by the CD82 gene. [5]

Contents

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the tetraspanin/transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [5]

Interactions

CD82 (gene) has been shown to interact with CD19, [6] [7] CD63 [8] and CD234. [9]

CD82 plays a key role in the development of endometriosis. [10]

See also

Related Research Articles

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A metastasis suppressor is a protein that acts to slow or prevent metastases from spreading in the body of an organism with cancer. Metastasis is one of the most lethal cancer processes. This process is responsible for about ninety percent of human cancer deaths. Proteins that act to slow or prevent metastases are different from those that act to suppress tumor growth. Genes for about a dozen such proteins are known in humans and other animals.

<span class="mw-page-title-main">TSPAN4</span> Protein-coding gene in humans

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<span class="mw-page-title-main">PTGFRN</span> Protein-coding gene in the species Homo sapiens

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. PTGFRN has also been designated as CD315.

<span class="mw-page-title-main">IGSF8</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">CD160</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000085117 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000027215 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 "Entrez Gene: CD82 CD82 molecule".
  6. ↑ Imai T, Kakizaki M, Nishimura M, Yoshie O (August 1995). "Molecular analyses of the association of CD4 with two members of the transmembrane 4 superfamily, CD81 and CD82". Journal of Immunology. 155 (3): 1229–39. doi:10.4049/jimmunol.155.3.1229. PMID   7636191. S2CID   32942467.
  7. ↑ Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (November 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi: 10.1074/jbc.273.46.30537 . PMID   9804823.
  8. ↑ Hammond C, Denzin LK, Pan M, Griffith JM, Geuze HJ, Cresswell P (October 1998). "The tetraspan protein CD82 is a resident of MHC class II compartments where it associates with HLA-DR, -DM, and -DO molecules". Journal of Immunology. 161 (7): 3282–91. doi: 10.4049/jimmunol.161.7.3282 . PMID   9759843.
  9. ↑ Hur J, Choi JI, Lee H, Nham P, Kim TW, Chae CW, et al. (April 2016). "CD82/KAI1 Maintains the Dormancy of Long-Term Hematopoietic Stem Cells through Interaction with DARC-Expressing Macrophages". Cell Stem Cell. 18 (4): 508–21. doi: 10.1016/j.stem.2016.01.013 . PMID   26996598.
  10. ↑ Timologou A, Zafrakas M, Grimbizis G, Miliaras D, Kotronis K, Stamatopoulos P, Tarlatzis B (February 2016). "Immunohistochemical expression pattern of metastasis suppressors". European Journal of Obstetrics & Gynecology and Reproductive Biology. 199: 110–115. doi:10.1016/j.ejogrb.2016.02.004. PMID   26918694.

Further reading

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