Integrin alpha 2b

Last updated
ITGA2B
Protein ITGA2B PDB 1txv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITGA2B , BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDs OMIM: 607759 MGI: 96601 HomoloGene: 37304 GeneCards: ITGA2B
Orthologs
SpeciesHumanMouse
Entrez

3674

16399

Ensembl

ENSG00000005961

ENSMUSG00000034664

UniProt

P08514

Q9QUM0

RefSeq (mRNA)

NM_000419

NM_010575

RefSeq (protein)

NP_000410

NP_034705

Location (UCSC) Chr 17: 44.37 – 44.39 Mb Chr 11: 102.34 – 102.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. [5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [6]

Interactions

ITGA2B has been shown to interact with AUP1 [7] and CLNS1A. [8]

See also

Related Research Articles

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<span class="mw-page-title-main">Multimerin 1</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000005961 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034664 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1): 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC   6901466 . PMID   31819097.
  6. ↑ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
  7. ↑ Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. United States. 277 (32): 28934–41. doi: 10.1074/jbc.M204340200 . ISSN   0021-9258. PMID   12042322.
  8. ↑ Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. United States. 279 (26): 27286–93. doi: 10.1074/jbc.M402159200 . ISSN   0021-9258. PMID   15075326.

Further reading

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