Integrin alpha 2b

Last updated

ITGA2B
Protein ITGA2B PDB 1txv.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITGA2B , BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3, PPP1R93, integrin subunit alpha 2b, GT1
External IDs OMIM: 607759; MGI: 96601; HomoloGene: 37304; GeneCards: ITGA2B; OMA:ITGA2B - orthologs
Orthologs
SpeciesHumanMouse
Entrez

3674

16399

Ensembl

ENSG00000005961

ENSMUSG00000034664

UniProt

P08514

Q9QUM0

RefSeq (mRNA)

NM_000419

NM_010575

RefSeq (protein)

NP_000410

NP_034705

Location (UCSC) Chr 17: 44.37 – 44.39 Mb Chr 11: 102.34 – 102.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Integrin alpha-IIb is a protein that in humans is encoded by the ITGA2B gene. ITGA2B, also known as CD41, encodes integrin alpha chain 2b. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes post-translational cleavage to yield disulfide-linked light and heavy chains that join with beta 3 to form a fibrinogen receptor expressed in platelets that plays a crucial role in coagulation. Mutations that interfere with this role result in thrombasthenia. At least 38 disease-causing mutations in this gene have been discovered. [5] In addition to adhesion, integrins are known to participate in cell-surface mediated signalling. [6]

Interactions

ITGA2B has been shown to interact with AUP1 [7] and CLNS1A. [8]

See also

Related Research Articles

<span class="mw-page-title-main">Coagulation</span> Process of formation of blood clots

Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot. It results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The process of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin.

<span class="mw-page-title-main">Glanzmann's thrombasthenia</span> Medical condition

Glanzmann's thrombasthenia is an abnormality of the platelets. It is an extremely rare coagulopathy, in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to other platelets can occur, and the bleeding time is significantly prolonged.

In medicine, glycoprotein IIb/IIIa inhibitors, also GpIIb/IIIa inhibitors, is a class of antiplatelet agents.

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CD11c, also known as Integrin, alpha X (ITGAX), is a gene that encodes for CD11c.

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<span class="mw-page-title-main">Apolipoprotein H</span> Protein-coding gene in humans

β2-glycoprotein 1, also known as beta-2 glycoprotein 1 and Apolipoprotein H (Apo-H), is a 38 kDa multifunctional plasma protein that in humans is encoded by the APOH gene. One of its functions is to bind cardiolipin. When bound, the structure of cardiolipin and β2-GP1 both undergo large changes in structure. Within the structure of Apo-H is a stretch of positively charged amino acids, Lys-Asn-Lys-Glu-Lys-Lys, are involved in phospholipid binding.

<span class="mw-page-title-main">Integrin alpha 2</span> Mammalian protein found in Homo sapiens

Integrin alpha-2, or CD49b, is a protein which in humans is encoded by the CD49b gene.

<span class="mw-page-title-main">Integrin beta 3</span> Mammalian protein found in Homo sapiens

Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.

<span class="mw-page-title-main">Fibrinogen gamma chain</span> Protein-coding gene in the species Homo sapiens

Fibrinogen gamma chain, also known as fibrinogen gamma gene (FGG), is a human gene found on chromosome 3.

<span class="mw-page-title-main">Integrin alpha V</span> Mammalian protein found in Homo sapiens

Integrin alpha-V is a protein that in humans is encoded by the ITGAV gene.

<span class="mw-page-title-main">Integrin alpha 5</span> Protein

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene.

Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis. When the blood vessel wall is damaged, platelet membrane glycoproteins interact with the extracellular matrix.

<span class="mw-page-title-main">GP1BA</span> Protein-coding gene in the species Homo sapiens

Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b, is a protein that in humans is encoded by the GP1BA gene.

<span class="mw-page-title-main">F2RL3</span> Protein-coding gene in the species Homo sapiens

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.

<span class="mw-page-title-main">GP1BB</span> Protein-coding gene in the species Homo sapiens

Glycoprotein Ib (platelet), beta polypeptide (GP1BB) also known as CD42c, is a protein that in humans is encoded by the GP1BB gene.

<span class="mw-page-title-main">Glycoprotein IX</span> Protein-coding gene in the species Homo sapiens

Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene.

<span class="mw-page-title-main">GP5 (gene)</span> Protein-coding gene in the species Homo sapiens

Glycoprotein V (platelet) (GP5) also known as CD42d (Cluster of Differentiation 42d), is a human gene.

<span class="mw-page-title-main">Multimerin 1</span> Protein-coding gene in the species Homo sapiens

Multimerin 1, also known as elastin microfibril interfacer 4 (EMILIN-4), is a protein that, in humans, is encoded by the MMRN1 gene.

Ellinor Peerschke was an American scientist specializing in coagulation, complement, and platelet biology.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000005961 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034664 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Šimčíková D, Heneberg P (December 2019). "Refinement of evolutionary medicine predictions based on clinical evidence for the manifestations of Mendelian diseases". Scientific Reports. 9 (1): 18577. Bibcode:2019NatSR...918577S. doi:10.1038/s41598-019-54976-4. PMC   6901466 . PMID   31819097.
  6. ↑ "Entrez Gene: ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)".
  7. ↑ Kato A, Kawamata Norihiko, Tamayose Kenji, Egashira Motoki, Miura Rika, Fujimura Tsutomu, Murayama Kimie, Oshimi Kazuo (Aug 2002). "Ancient ubiquitous protein 1 binds to the conserved membrane-proximal sequence of the cytoplasmic tail of the integrin alpha subunits that plays a crucial role in the inside-out signaling of alpha IIbbeta 3". J. Biol. Chem. 277 (32). United States: 28934–41. doi: 10.1074/jbc.M204340200 . ISSN   0021-9258. PMID   12042322.
  8. ↑ Larkin D, Murphy Derek, Reilly Dermot F, Cahill Martha, Sattler Ellen, Harriott Pat, Cahill Dolores J, Moran Niamh (Jun 2004). "ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation". J. Biol. Chem. 279 (26). United States: 27286–93. doi: 10.1074/jbc.M402159200 . ISSN   0021-9258. PMID   15075326.

Further reading

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