Hyoscine

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Hyoscine
L-Scopolamin.svg
Scopolamine structure.png
Clinical data
Trade names Transdermscop, Kwells, others
Other namesScopolamine, hyoscine hydrobromide, scopolamine hydrobromide [1]
AHFS/Drugs.com Monograph
MedlinePlus a682509
License data
Pregnancy
category
  • AU:B2
Routes of
administration 		By mouth, skin patch, eye drops, subcutaneous, intravenous, sublingual, rectal, buccal transmucosal, intramuscular
ATC code
Legal status
Legal status
Pharmacokinetic data
Metabolism Liver
Elimination half-life 4.5 hours [5]
Excretion Kidney
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard 100.000.083 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C17H21NO4
Molar mass 303.358 g·mol−1
3D model (JSmol)
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Hyoscine, also known as scopolamine, [6] is a medication used to treat motion sickness and postoperative nausea and vomiting. [1] It is also sometimes used before surgery to decrease saliva. [1] When used by injection, effects begin after about 20 minutes and last for up to 8 hours. [1] It may also be used by mouth and as a transdermal patch. [1]

Contents

Common side effects include sleepiness, blurred vision, dilated pupils, and dry mouth. [1] It is not recommended in people with angle-closure glaucoma or bowel obstruction. [1] Whether use during pregnancy is safe is unclear, but its use appears to be safe during breastfeeding. [7] Hyoscine is in the antimuscarinic family of medications and works by blocking some of the effects of acetylcholine within the nervous system. [1]

Hyoscine was first written about in 1881 and started to be used for anesthesia around 1900. [8] [9] It is on the World Health Organization's List of Essential Medicines. [10] Hyoscine is the main active component produced by certain plants of the nightshade family, which historically have been used as psychoactive drugs due to their hallucinogenic effects. [11] The name "scopolamine" is derived from one type of nightshade known as Scopolia , while the name "hyoscine" is derived from another type known as Hyoscyamus niger . [12] [13]

Medical use

Hyoscine has a number of uses in medicine, where it is used to treat: [14] [15]

It is sometimes used as a premedication, (especially to reduce respiratory tract secretions) in surgery, most commonly by injection. [14] [15]

Breastfeeding

Hyoscine enters breast milk by secretion. Although no human studies exist to document the safety of hyoscine while nursing, the manufacturer recommends that caution be taken if hyoscine is administered to a breastfeeding woman. [19]

Elderly

The likelihood of experiencing adverse effects from hyoscine is increased in the elderly relative to younger people. This phenomenon is especially true for older people who are also on several other medications. Hyoscine use should be avoided in this age group because of these potent anticholinergic adverse effects, which have also been linked to an increased risk for dementia. [20] [21]

Adverse effects

Adverse effect incidence: [22] [23] [24] [25]

Uncommon (0.1–1% incidence) adverse effects include:

Rare (<0.1% incidence) adverse effects include:

Unknown frequency adverse effects include:

Overdose

Physostigmine, a cholinergic drug that readily crosses the blood-brain barrier, has been used as an antidote to treat the central nervous system depression symptoms of a hyoscine overdose. [26] Other than this supportive treatment, gastric lavage and induced emesis (vomiting) are usually recommended as treatments for oral overdoses. [25] The symptoms of overdose include: [24] [25]

Interactions

Due to interactions with metabolism of other drugs, hyoscine can cause significant unwanted side effects when taken with other medications. Specific attention should be paid to other medications in the same pharmacologic class as hyoscine, also known as anticholinergics. These medications could potentially interact with the metabolism of hyoscine: analgesics/pain medications, ethanol, zolpidem, thiazide diuretics, buprenorphine, anticholinergic drugs such as tiotropium, etc.

Route of administration

Hyoscine can be taken by mouth, subcutaneously, ophthalmically, and intravenously, as well as via a transdermal patch. [27] The transdermal patch (e.g., Transderm Scōp) for prevention of nausea and motion sickness employs hyoscine base, and is effective for up to three days. [28] The oral, ophthalmic, and intravenous forms have shorter half-lives and are usually found in the form hyoscine hydrobromide (for example in Scopace, soluble tablets or Donnatal).

NASA is currently developing a nasal administration method. With a precise dosage, the NASA spray formulation has been shown to work faster and more reliably than the oral form. [29]

Pharmacodynamics

The muscarinic antagonism of scopolamine remains the standard method for inducing cognitive deficits in animals and in healthy volunteers. Thus, it used as a relevant preclinical model for pharmacological profiling of new therapeutics. [30] Methyllycaconitine- and scopolamine-induced cognitive dysfunction: differential reversal effect by cognition-enhancing drugs

Scopolamine is a nonspecific muscarinic antagonist at all four muscarinic acetylcholine receptors (M1, M2, M3, and M4)., [31] [32]

Biosynthesis in plants

Hyoscine is among the secondary metabolites of plants from Solanaceae (nightshade) family of plants, such as henbane (Hyoscyamus niger), jimson weed ( Datura ), angel's trumpets ( Brugmansia ), and corkwood ( Duboisia ). [33] [12]

The biosynthesis of hyoscine begins with the decarboxylation of L-ornithine to putrescine by ornithine decarboxylase. Putrescine is methylated to N-methylputrescine by putrescine N-methyltransferase. [34]

A putrescine oxidase that specifically recognizes methylated putrescine catalyzes the deamination of this compound to 4-methylaminobutanal, which then undergoes a spontaneous ring formation to N-methyl-pyrrolium cation. In the next step, the pyrrolium cation condenses with acetoacetic acid yielding hygrine. No enzymatic activity could be demonstrated to catalyze this reaction. Hygrine further rearranges to tropinone. [34]

Subsequently, tropinone reductase I converts tropinone to tropine, which condenses with phenylalanine-derived phenyllactate to littorine. A cytochrome P450 classified as Cyp80F1 [35] oxidizes and rearranges littorine to hyoscyamine aldehyde. In the final step, hyoscyamine undergoes epoxidation catalyzed by 6beta-hydroxyhyoscyamine epoxidase yielding hyoscine. [34]

Scopolamine biosynthesis.svg

History

One of the earlier alkaloids isolated from plant sources, hyoscine has been in use in its purified forms (such as various salts, including hydrochloride, hydrobromide, hydroiodide, and sulfate), since its isolation by the German scientist Albert Ladenburg in 1880, [36] and as various preparations from its plant-based form since antiquity and perhaps prehistoric times. Following the description of the structure and activity of hyoscine by Ladenburg, the search for synthetic analogues, and methods for total synthesis, of hyoscine and/or atropine in the 1930s and 1940s resulted in the discovery of diphenhydramine, an early antihistamine and the prototype of its chemical subclass of these drugs, and pethidine, the first fully synthetic opioid analgesic, known as Dolantin and Demerol amongst many other trade names.

In 1899, a Dr. Schneiderlin recommended the use of hyoscine and morphine for surgical anaesthesia, and it started to be used sporadically for that purpose. [8] [37] The use of this combination in obstetric anesthesiology was first proposed by Richard von Steinbuchel in 1902 and was picked up and further developed by Carl Gauss in Freiburg, Germany starting in 1903. [38] The method came to be known as Dämmerschlaf ("twilight sleep") or the "Freiburg method". [37] [38] It spread rather slowly, and different clinics experimented with different dosages and ingredients; in 1915, the Canadian Medical Association Journal reported, "the method [was] really still in a state of development". [37] It remained widely used in the US until the 1960s, when growing chemophobia and a desire for more natural childbirth led to its abandonment. [39]

Society and culture

Names

Hyoscine hydrobromide is the international nonproprietary name, and scopolamine hydrobromide is the United States Adopted Name. Other names include levo-duboisine, devil's breath, and burundanga. [40] [41]

Australian bush medicine

A bush medicine developed by Aboriginal peoples of the eastern states of Australia from the soft corkwood tree ( Duboisia myoporoides ) was used by the Allies in World War II to stop soldiers from getting seasick when they sailed across the English Channel on their way to France during the Invasion of Normandy. Later, the same substance was found to be usable in the production of scopolamine and hyoscyamine, which are used in eye surgery, and a multimillion dollar industry was built in Queensland based on this substance. [42]

Recreational and religious use

While it has been occasionally used recreationally for its hallucinogenic properties, the experiences are often unpleasant, mentally and physically. It is also physically dangerous and formally classified as a deliriant drug, so repeated use is rare. [43] In June 2008, more than 20 people were hospitalized with psychosis in Norway after ingesting counterfeit rohypnol tablets containing hyoscine. [44] In January 2018, 9 individuals were hospitalized in Perth, Western Australia, after reportedly ingesting hyoscine. [45]

Historically, the various plants that produce hyoscine have been used psychoactively for spiritual purposes. [46] [47] When entheogenic preparations of these plants were used, hyoscine was considered to be the main psychoactive compound and was largely responsible for the hallucinogenic effects, particularly when the preparation was made into a topical ointment (most notably flying ointment). [48] Hyoscine is reported to be the only active alkaloid within these plants that can effectively be absorbed through the skin to cause effects. [49] Different recipes for these ointments were explored in European witchcraft at least as far back as the Early Modern period and included multiple ingredients to help with the transdermal absorption of hyoscine (such as animal fat), as well as other possible ingredients to counteract its noxious and dysphoric effects. [48]

Interrogation

The effects of hyoscine were studied for use as a truth serum in interrogations in the early 20th century, [50] but because of the side effects, investigations were dropped. [51] In 2009, the Czechoslovak state security secret police were proven to have used hyoscine at least three times to obtain confessions from alleged antistate dissidents. [52]

Crime

A travel advisory published by the United States Department of State in 2012 stated: "One common and particularly dangerous method that criminals use in order to rob a victim is through the use of drugs. The most common [in Colombia] has been hyoscine. Unofficial estimates put the number of annual hyoscine incidents in Colombia at approximately 50,000. Hyoscine can render a victim unconscious for 24 hours or more. In large doses, it can cause respiratory failure and death. It is most often administered in liquid or powder form in foods and beverages. The majority of these incidents occur in night clubs and bars, and usually men, perceived to be wealthy, are targeted by young, attractive women. It is recommended that, to avoid becoming a victim of hyoscine, a person should never accept food or beverages offered by strangers or new acquaintances, nor leave food or beverages unattended in their presence. Victims of hyoscine or other drugs should seek immediate medical attention." [53]

Between 1998 and 2004, 13% of emergency-room admissions for "poisoning with criminal intentions" in a clinic of Bogotá, Colombia have been attributed to hyoscine, and 44% to benzodiazepines. [40] Most commonly, the person has been poisoned by a robber who gave the victim a scopolamine-laced beverage, in the hope that the victim would become unconscious or unable to effectively resist the robbery. [40]

Beside robberies, it is also allegedly involved in express kidnappings and sexual assault. [54] The Hospital Clínic in Barcelona introduced a protocol in 2008 to help medical workers identify cases, while Madrid hospitals adopted a similar working document in February 2015. [54] Hospital Clínic has found little scientific evidence to support this use and relies on the victims' stories to reach any conclusion. [54] Although poisoning by hyoscine appears quite often in the media as an aid for raping, kidnapping, killing, or robbery, the effects of this drug and the way it is applied by criminals (transdermal injection, on playing cards and papers, etc.) are often exaggerated, [55] [56] [57] especially skin exposure, as the dose that can be absorbed by the skin is too low to have any effect. [54] Hyoscine transdermal patches must be used for hours to days. [27] Certain other aspects of the usage of hyoscine in crimes have equally been described as "exaggerated" or even implausible. [58] Powdered hyoscine, in a form referred to as "devil's breath", does not brainwash or control people into being defrauded by their attackers; these alleged effects are most likely urban legends. [59] Nevertheless, the drug is known to produce loss of memory following exposure and sleepiness, similar to the effect of benzodiazepines or alcohol poisoning.

Research

Hyoscine is used as a research tool to study memory encoding. Initially, in human trials, relatively low doses of the muscarinic receptor antagonist, scopolamine, were found to induce temporary cognitive defects. [60] Since then, scopolamine has become a standard drug for experimentally inducing cognitive defects in animals. [61] [62] Results in primates suggest that acetylcholine is involved in the encoding of new information into long-term memory. [63]

Hyoscine produces detrimental effects on short-term memory, memory acquisition, learning, visual recognition memory, visuospatial praxis, visuospatial memory, visuoperceptual function, verbal recall, and psychomotor speed. [64] [61] [62] It does not seem to impair recognition and memory retrieval, though. [62] Acetylcholine projections in hippocampal neurons, which are vital in mediating long-term potentiation, are inhibited by scopolamine. [62] [65] Hyoscine also inhibits cholinergic-mediated glutamate release in hippocampal neurons, which assist in depolarization, potentiation of action potential, and synaptic suppression. Hyoscine's effects on acetylcholine and glutamate release in the hippocampus favor retrieval-dominant cognitive functioning. [62] Hyoscine has been used to model the defects in cholinergic function for models of Alzheimer's, dementia, fragile X syndrome, and Down syndrome. [62] [66] [67] [68]

Hyoscine has also been investigated as a rapid-onset antidepressant, with a number of small studies finding positive results. [69] [70] [71] [72]

See also

Related Research Articles

Nicotine Mild chemical stimulant naturally found in some plants

Nicotine is a chiral alkaloid that is naturally produced in the nightshade family of plants and is widely used as a stimulant. As a pharmaceutical drug, it is used for smoking cessation to relieve withdrawal symptoms. Nicotine acts as a receptor agonist at most nicotinic acetylcholine receptors (nAChRs), except at two nicotinic receptor subunits where it acts as a receptor antagonist.

Acetylcholine Organic chemical and neurotransmitter

Acetylcholine (ACh) is an organic chemical that functions in the brain and body of many types of animals as a neurotransmitter—a chemical message released by nerve cells to send signals to other cells, such as neurons, muscle cells and gland cells. Its name is derived from its chemical structure: it is an ester of acetic acid and choline. Parts in the body that use or are affected by acetylcholine are referred to as cholinergic. Substances that increase or decrease the overall activity of the cholinergic system are called cholinergics and anticholinergics, respectively.

Atropine pharmaceutical drug

Atropine is a medication used to treat certain types of nerve agent and pesticide poisonings as well as some types of slow heart rate, and to decrease saliva production during surgery. It is typically given intravenously or by injection into a muscle. Eye drops are also available which are used to treat uveitis and early amblyopia. The intravenous solution usually begins working within a minute and lasts half an hour to an hour. Large doses may be required to treat some poisonings.

Benzatropine

Benzatropine (INN), known as benztropine in the United States and Japan, is a medication used to treat a type of movement disorder due to antipsychotics known as dystonia and parkinsonism. It is not useful for tardive dyskinesia. It is taken by mouth or by injection into a vein or muscle. Benefits are seen within two hours and last for up to ten hours.

<i>Atropa belladonna</i> Species of toxic flowering plant in the nightshade family.

Atropa belladonna, commonly known as belladonna or deadly nightshade, is a poisonous perennial herbaceous plant in the nightshade family Solanaceae, which also includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States.

Hyoscyamine Pharmaceutical drug

Hyoscyamine is a naturally occurring tropane alkaloid and plant toxin. It is a secondary metabolite found in certain plants of the family Solanaceae, including henbane, mandrake, angel's trumpets, jimsonweed, tomato, the sorcerers' tree, and deadly nightshade. It is the levorotary isomer of atropine and thus sometimes known as levo-atropine.

Anticholinergics are a group of substances that blocks the action of the neurotransmitter called acetylcholine (ACh) at synapses in the central and peripheral nervous system.

Chlorphenamine

Chlorphenamine, also known as chlorpheniramine, is an antihistamine used to treat the symptoms of allergic conditions such as allergic rhinitis. It is taken by mouth. The medication takes effect within 6 hours and lasts for about a day.

A parasympathomimetic drug, sometimes called a cholinomimetic drug or cholinergic receptor stimulating agent, is a substance that stimulates the parasympathetic nervous system (PSNS). These chemicals are also called cholinergic drugs because acetylcholine (ACh) is the neurotransmitter used by the PSNS. Chemicals in this family can act either directly by stimulating the nicotinic or muscarinic receptors, or indirectly by inhibiting cholinesterase, promoting acetylcholine release, or other mechanisms.

Muscarinic acetylcholine receptor Acetylcholine receptors named for their selective binding of muscarine

Muscarinic acetylcholine receptors, or mAChRs, are acetylcholine receptors that form G protein-coupled receptor complexes in the cell membranes of certain neurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibers in the parasympathetic nervous system.

Galantamine

Galantamine,, is used for the treatment of cognitive decline in mild to moderate Alzheimer's disease and various other memory impairments. It is an alkaloid that has been isolated from the bulbs and flowers of Galanthus nivalis, Galanthus caucasicus, Galanthus woronowii, and some other members of the family Amaryllidaceae, such as Narcissus (daffodil), Leucojum aestivum (snowflake), and Lycoris including Lycoris radiata. It can also be produced synthetically.

Deliriant Class of psychoactive drugs

Deliriants are a class of hallucinogen. The term was introduced by David F. Duncan and Robert S. Gold to distinguish these drugs from psychedelics and dissociatives, such as LSD and ketamine respectively, due to their primary effect of causing delirium, as opposed to the more lucid states produced by such other hallucinogens as those represented by psychedelics and dissociatives. The term is generally used to refer to anticholinergic drugs which are substances that inhibit the function of the neurotransmitter acetylcholine. Common examples of deliriants include plants of the genus Datura as well as higher than recommended dosages of Diphenhydramine (Benadryl).

Hyoscine butylbromide

Hyoscine butylbromide, also known as scopolamine butylbromide and sold under the brandname Buscopan among others, is an anticholinergic medication used to treat crampy abdominal pain, esophageal spasms, renal colic, and bladder spasms. It is also used to improve respiratory secretions at the end of life. Hyoscine butylbromide can be taken by mouth, injection into a muscle, or into a vein.

Methacholine

Methacholine is a synthetic choline ester that acts as a non-selective muscarinic receptor agonist in the parasympathetic nervous system.

A cholinergic crisis is an over-stimulation at a neuromuscular junction due to an excess of acetylcholine (ACh), as a result of the inactivity of the AChE enzyme, which normally breaks down acetylcholine.

Oxybutynin Bladder medication

Oxybutynin, sold as under the brand names Ditropan among others, is a medication used to treat overactive bladder. It works similar to tolterodine. While used for bed wetting in children, evidence to support this use is poor. It is taken by mouth or applied to the skin.

Muscarinic agonist

A muscarinic agonist is an agent that activates the activity of the muscarinic acetylcholine receptor. The muscarinic receptor has different subtypes, labelled M1-M5, allowing for further differentiation.

Methylscopolamine bromide

Methylscopolamine or methscopolamine, usually provided as the bromide or nitrate salt, is an oral medication used along with other medications to treat peptic ulcers by reducing stomach acid secretion. Proton pump inhibitors and antihistamine medications have made this use obsolete. It can also be used for stomach or intestinal spasms, to reduce salivation, and to treat motion sickness. Methscopolamine is also commonly used as a drying agent, to dry up post-nasal drip, in cold, irritable bowel syndrome and allergy medications

Muscarinic antagonist Drug that binds to but does not activate muscarinic cholinergic receptors

A muscarinic receptor antagonist (MRA) is a type of anticholinergic agent that blocks the activity of the muscarinic acetylcholine receptor. The muscarinic receptor is a protein involved in the transmission of signals through certain parts of the nervous system, and muscarinic receptor antagonists work to prevent this transmission from occurring. Notably, muscarinic antagonists reduce the activation of the parasympathetic nervous system. The normal function of the parasympathetic system is often summarised as "rest-and-digest", and includes slowing of the heart, an increased rate of digestion, narrowing of the airways, promotion of urination, and sexual arousal. Muscarinic antagonists counter this parasympathetic "rest-and-digest" response, and also work elsewhere in both the central and peripheral nervous systems.

Indeloxazine

Indeloxazine (INN) is an antidepressant and cerebral activator that was marketed in Japan and South Korea by Yamanouchi Pharmaceutical Co., Ltd for the treatment of psychiatric symptoms associated with cerebrovascular diseases, namely depression resulting from stroke, emotional disturbance, and avolition. It was marketed from 1988 to 1998, when it was removed from the market reportedly for lack of effectiveness.

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