25C-NBF

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25C-NBF
25C-NBF.svg
Clinical data
Other names2C-C-NBF; NBF-2C-C
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII

25C-NBF (2C-C-NBF, NBF-2C-C) is a derivative of the phenethylamine hallucinogen 2C-C, which acts as a highly potent partial agonist for the human 5-HT2A receptor. [2] [3] [4] It produces psychoplastogenic and rapid antidepressant-like effects in preclinical research. [4]

Contents

Society and culture

Sweden

The Riksdag added 25C-NBF to Narcotic Drugs Punishments Act under swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of January 26, 2016, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:35 listed as 25C-NBF, and 2-(4-kloro-2,5-dimetoxifenyl)-N-(2-fluorobensyl)etanamin. [5]

United Kingdom

This substance is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause in the Misuse of Drugs Act 1971 . [6]

See also

References

  1. ↑ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  2. ↑ Hansen M, Phonekeo K, Paine JS, Leth-Petersen S, Begtrup M, Bräuner-Osborne H, Kristensen JL (March 2014). "Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists". ACS Chemical Neuroscience. 5 (3): 243–9. doi:10.1021/cn400216u. PMC   3963123 . PMID   24397362.
  3. ↑ Hansen M (2010-12-16). Design and Synthesis of Selective Serotonin Receptor Agonists for Positron Emission Tomography Imaging of the Brain (Ph.D. thesis). University of Copenhagen. doi:10.13140/RG.2.2.33671.14245.
  4. 1 2 Nadal-Gratacós N, Puigseslloses P, Guzmán L, Weiss N, Pottie E, Riera-Colomer C, Lardeux V, Thiriet N, Wang FH, Källsten L, Pérez-Esteban I, Ketsela G, Margall J, Berzosa X, Pubill D, Rodríguez-Arias M, Ettcheto M, Kehr J, Stove C, Solinas M, Sitte HH, Escubedo E, López-Arnau R (November 2025). "The psychedelic phenethylamine 25C-NBF, a selective 5-HT2A agonist, shows psychoplastogenic properties and rapid antidepressant effects in male rodents". Mol Psychiatry. doi:10.1038/s41380-025-03341-1. PMID   41238841.
  5. ↑ "Archived copy" (PDF). Archived from the original (PDF) on 2017-10-31. Retrieved 2017-04-21.{{cite web}}: CS1 maint: archived copy as title (link)
  6. ↑ "The Misuse of Drugs Act 1971 (Ketamine etc.) (Amendment) Order 2014". UK Statutory Instruments 2014 No. 1106. www.legislation.gov.uk.
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