OR2M4

OR2M4
Identifiers
Aliases	OR2M4 , HSHTPCRX18, HTPCRX18, OR1-55, OST710, TPCR100, olfactory receptor family 2 subfamily M member 4
External IDs	HomoloGene: 88846 GeneCards: OR2M4
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q44 Start 248,231,417 bp [1] End 248,244,679 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in prefrontal cortex superior frontal gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26245 n/a Ensembl ENSG00000171180 n/a UniProt Q96R27 n/a RefSeq (mRNA) NM_017504 n/a RefSeq (protein) NP_059974 n/a Location (UCSC) Chr 1: 248.23 – 248.24 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Olfactory receptor 2M4 is a protein that in humans is encoded by the OR2M4 gene. ^{[3] [4] [5]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000171180 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. Bibcode:1992Natur.355..453P. doi:10.1038/355453a0. PMID   1370859. S2CID   43926.
4. Vanderhaeghen P, Schurmans S, Vassart G, Parmentier M (Apr 1997). "Specific repertoire of olfactory receptor genes in the male germ cells of several mammalian species". Genomics. 39 (3): 239–46. doi:10.1006/geno.1996.4490. PMID   9119360.
5. "Entrez Gene: OR2M4 olfactory receptor, family 2, subfamily M, member 4".

Further reading

• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.

External links

• OR2M4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.