OR1E2

OR1E2
Identifiers
Aliases	OR1E2 , OR17-135, OR17-93, OR1E4, OR1E7, OST529, OR17-136, olfactory receptor family 1 subfamily E member 2
External IDs	MGI: 109315 HomoloGene: 128054 GeneCards: OR1E2
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.2 Start 3,432,870 bp [1] End 3,433,841 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B4 Start 73,241,609 bp [2] End 73,246,777 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus lymph node Top expressed in spermatocyte More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process sensory perception of chemical stimulus sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8388 258925 Ensembl ENSG00000127780 ENSMUSG00000062128 UniProt P47887 Q7TRX9 RefSeq (mRNA) NM_003554 NM_146923 RefSeq (protein) NP_003545 NP_667134 Location (UCSC) Chr 17: 3.43 – 3.43 Mb Chr 11: 73.24 – 73.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 1E2 is a protein that in humans is encoded by the OR1E2 gene. ^{[5] [6] [7]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[7]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000127780 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000062128 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ben-Arie N, Lancet D, Taylor C, Khen M, Walker N, Ledbetter DH, Carrozzo R, Patel K, Sheer D, Lehrach H, et al. (Jul 1994). "Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire". Hum Mol Genet. 3 (2): 229–35. doi:10.1093/hmg/3.2.229. PMID   8004088.
6. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
7. "Entrez Gene: OR1E2 olfactory receptor, family 1, subfamily E, member 2".

Further reading

• Gotschlich EC (1975). "Development of polysaccharide vaccines for the prevention of meningococcal diseases". Monographs in Allergy. 9: 245–58. PMID   804088.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Glusman G, Sosinsky A, Ben-Asher E, et al. (2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID   10673334. S2CID   23416814.

External links

• OR1E2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.