OR4F3

OR4F3
Identifiers
Aliases	OR4F3 , olfactory receptor family 4 subfamily F member 3
External IDs	MGI: 3031137 HomoloGene: 88429 GeneCards: OR4F3
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q35.3 Start 181,367,268 bp [1] End 181,368,262 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E3 Start 111,642,592 bp [2] End 111,650,685 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver duodenum rectum placenta islet of Langerhans tibial nerve right lobe of thyroid gland myometrium temporal lobe amygdala n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity olfactory receptor activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell detection of chemical stimulus involved in sensory perception of smell detection of chemical stimulus involved in sensory perception signal transduction response to stimulus G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26683 258397 Ensembl ENSG00000230178 ENSMUSG00000093804 UniProt Q6IEY1 A2AVW1 RefSeq (mRNA) NM_001005224 NM_146402 RefSeq (protein) NP_001005224 NP_001005221 NP_001005277 NP_666514 Location (UCSC) Chr 5: 181.37 – 181.37 Mb Chr 2: 111.64 – 111.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 4F3/4F16/4F29 is a protein that in humans is encoded by the OR4F3 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. GRCh38: Ensembl release 89: ENSG00000230178 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000093804 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR4F3 olfactory receptor, family 4, subfamily F, member 3".

Further reading

• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.

External links

• OR4F3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.