OR7D4

Last updated
OR7D4
Identifiers
Aliases OR7D4 , OR19-7, OR19-B, OR19B, OR7D4P, hg105, olfactory receptor family 7 subfamily D member 4
External IDs OMIM: 611538 MGI: 1313142 HomoloGene: 81583 GeneCards: OR7D4
Orthologs
SpeciesHumanMouse
Entrez

125958

258822

Ensembl

ENSG00000174667

ENSMUSG00000059623

UniProt

Q8NG98

n/a

RefSeq (mRNA)

NM_001005191

NM_146825

RefSeq (protein)

NP_001005191

n/a

Location (UCSC) Chr 19: 9.21 – 9.22 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene. [4] [5] [6] [7] [8] [9] [10]

Contents

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [4]

Ligands

People with the OR7D4 R88W/T133M polymorphism are less sensitive to these odorants and find them less offensive smelling, as they are characteristically described as "sweaty". [7]

Related Research Articles

Olfactory receptors (ORs), also known as odorant receptors, are expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants which give rise to the sense of smell. Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. These receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene family consisting of around 800 genes in humans and 1400 genes in mice.

Androstenone Chemical compound

Androstenone (5α-androst-16-en-3-one) is a steroidal pheromone. It is found in boar's saliva, celery cytoplasm, and truffle fungus. Androstenone was the first mammalian pheromone to be identified. It is found in high concentrations in the saliva of male pigs, and, when inhaled by a female pig that is in heat, results in the female assuming the mating stance. Androstenone is the active ingredient in 'Boarmate', a commercial product made by DuPont sold to pig farmers to test sows for timing of artificial insemination.

Hyperosmia is an increased olfactory acuity, usually caused by a lower threshold for odor. This perceptual disorder arises when there is an abnormally increased signal at any point between the olfactory receptors and the olfactory cortex. The causes of hyperosmia may be genetic, hormonal, environmental or the result of benzodiazepine withdrawal syndrome.

OR2C1

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.

OR1A1

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.

OR2W1

Olfactory receptor 2W1 is a protein that in humans is encoded by the OR2W1 gene.

OR2J2

Olfactory receptor 2J2 is a protein that in humans is encoded by the OR2J2 gene.

OR51E2

Olfactory receptor 51E2 is a protein that in humans is encoded by the OR51E2 gene.

OR51L1

Olfactory receptor 51L1 is a protein that in humans is encoded by the OR51L1 gene.

OR56A4 Protein-coding gene in humans

Olfactory receptor 56A4 is a protein that in humans is encoded by the OR56A4 gene.

OR10J5

Olfactory receptor 10J5 is a protein that in humans is encoded by the OR10J5 gene.

OR11H6

Olfactory receptor 11H6 is a protein that in humans is encoded by the OR11H6 gene.

OR2M3

Olfactory receptor 2M3 is a protein that in humans is encoded by the OR2M3 gene.

OR2AG1

Olfactory receptor 2AG1 is a protein that in humans is encoded by the OR2AG1 gene.

OR51E1

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.

OR13C9

Olfactory receptor 13C9 is a protein that in humans is encoded by the OR13C9 gene.

OR5W2

Olfactory receptor 5W2 is a protein that in humans is encoded by the OR5W2 gene.

OR11H4

Olfactory receptor 11H4 is a protein that in humans is encoded by the OR11H4 gene.

OR2M7

Olfactory receptor 2M7 is a protein that in humans is encoded by the OR2M7 gene.

OR2J3

Olfactory receptor 2J3 is a protein that in humans is encoded by the OR2J3 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000174667 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. 1 2 "Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4" . Retrieved 2013-12-17.
  5. ↑ Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX   10.1.1.135.3652 . doi:10.1006/geno.2002.6830. PMID   12213199.
  6. ↑ Malnic B, Godfrey PA, Buck LB (February 2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–9. doi:10.1073/pnas.0307882100. PMC   356993 . PMID   14983052.
  7. 1 2 Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H (September 2007). "Genetic variation in a human odorant receptor alters odour perception". Nature. 449 (7161): 468–72. doi:10.1038/nature06162. PMID   17873857. S2CID   4417235.
  8. ↑ OR7D4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
  9. ↑ Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H (2012). Behrens M (ed.). "Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone". PLOS ONE. 7 (5): e35259. doi:10.1371/journal.pone.0035259. PMC   3342276 . PMID   22567099.
  10. ↑ Wysocki CJ, Beauchamp GK (August 1984). "Ability to smell androstenone is genetically determined". Proceedings of the National Academy of Sciences of the United States of America. 81 (15): 4899–902. doi:10.1073/pnas.81.15.4899. PMC   391599 . PMID   6589634.
  11. ↑ Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B (February 2018). "Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction". Hormones and Behavior. 98: 45–54. doi:10.1016/j.yhbeh.2017.12.003. PMID   29246659. S2CID   3577638.
  12. ↑ de March CA, Topin J, Bruguera E, Novikov G, Ikegami K, Matsunami H, Golebiowski J (April 2018). "Odorant Receptor 7D4 Activation Dynamics". Angewandte Chemie. 57 (17): 4554–4558. doi:10.1002/anie.201713065. PMC   6268213 . PMID   29462498.

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