OR13A1

OR13A1
Identifiers
Aliases	OR13A1 , olfactory receptor family 13 subfamily A member 1
External IDs	MGI: 3030045 HomoloGene: 17434 GeneCards: OR13A1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q11.21 Start 45,302,298 bp [1] End 45,315,608 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 E3 Start 116,466,052 bp [2] End 116,475,182 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lymph node spleen blood urinary bladder cerebellar cortex cerebellar hemisphere appendix islet of Langerhans thymus prefrontal cortex Top expressed in respiratory epithelium olfactory epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity odorant binding olfactory receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane membrane Biological process sensory perception of smell signal transduction response to stimulus detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 79290 258914 Ensembl ENSG00000277495 ENSG00000256574 ENSMUSG00000053391 UniProt Q8NGR1 Q8VGH2 RefSeq (mRNA) NM_001004297 NM_146912 RefSeq (protein) NP_001004297 NP_667123 Location (UCSC) Chr 10: 45.3 – 45.32 Mb Chr 6: 116.47 – 116.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 13A1 is a protein that in humans is encoded by the OR13A1 gene. ^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[5]

See also

• Olfactory receptor

References

1. ENSG00000256574 GRCh38: Ensembl release 89: ENSG00000277495, ENSG00000256574 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053391 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OR13A1 olfactory receptor, family 13, subfamily A, member 1".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–381. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.

External links

• OR13A1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.