OR2F1

OR2F1
Identifiers
Aliases	OR2F1 , OLF3, OR14-60, OR2F3, OR2F3P, OR2F4, OR2F5, OR7-139, OR7-140, 7M1-2, olfactory receptor family 2 subfamily F member 1 (gene/pseudogene), olfactory receptor family 2 subfamily F member 1
External IDs	OMIM: 608497 MGI: 3030287 HomoloGene: 128151 GeneCards: OR2F1
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q35 Start 143,954,844 bp [1] End 143,997,312 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 42,716,305 bp [2] End 42,723,897 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue sural nerve placenta ascending aorta appendix right coronary artery fundus substantia nigra hippocampus proper temporal lobe n/a More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity olfactory receptor activity Cellular component membrane integral component of membrane plasma membrane Biological process response to stimulus signal transduction sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26211 258016 Ensembl ENSG00000284866 ENSG00000213215 ENSMUSG00000095831 UniProt Q13607 Q7TRV7 RefSeq (mRNA) NM_012369 NM_001011799 RefSeq (protein) NP_036501 NP_001011799 Location (UCSC) Chr 7: 143.95 – 144 Mb Chr 6: 42.72 – 42.72 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2F1 is a protein that in humans is encoded by the OR2F1 gene. ^{[5] [6]}

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. ^[6]

See also

• Olfactory receptor

References

1. ENSG00000213215 GRCh38: Ensembl release 89: ENSG00000284866, ENSG00000213215 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000095831 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Rouquier S, Taviaux S, Trask BJ, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D (Mar 1998). "Distribution of olfactory receptor genes in the human genome". Nat Genet. 18 (3): 243–50. doi:10.1038/ng0398-243. PMID   9500546. S2CID   31129045.
6. "Entrez Gene: OR2F1 olfactory receptor, family 2, subfamily F, member 1".

Further reading

• Issel-Tarver L, Rine J (1997). "The evolution of mammalian olfactory receptor genes". Genetics. 145 (1): 185–95. doi:10.1093/genetics/145.1.185. PMC   1207777 . PMID   9017400.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID   12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi: 10.1074/jbc.M212424200 . PMID   12637542.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi: 10.1038/nature01782 . PMID   12853948.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi: 10.1073/pnas.0307882100 . PMC   356993 . PMID   14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.

External links

• OR2F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.